Assignment of the relative and absolute configuration of marine natural products using NMR spectroscopy and computational approaches

使用核磁共振波谱和计算方法分配海洋天然产物的相对和绝对构型

• 批准号: 71001140
• 负责人: Privatdozent Dr. Matthias Koeck
• 金额: --
• 依托单位: Alfred-Wegener-Institut (AWI) Helmholtz-Zentrum für Polar- und Meeresforschung
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/71001140?language=en
• 关键词: Assignment; relative; absolute; configuration; marine

The major goal of this project is the isolation and identification of new natural products applying NMR and computational methods to elucidate their structures, including the relative and absolute configuration as already described in the first application. The distance geometry approach will be extended to include RDCs since it is most suited for constitutionally diverse molecules. This, and the possibility for enantiomer differentiating alignment may ultimately lead to the determination of absolute configurations.

该项目的主要目标是应用NMR和计算方法分离和鉴定新的天然产物，以阐明其结构，包括第一次申请中已经描述的相对和绝对构型。距离几何方法将扩展到包括RDC，因为它最适合于组成不同的分子。这一点，以及对映异构体区分对齐的可能性，最终可能导致绝对构型的确定。

项目成果

Configurational analysis of tetracyclic dimeric pyrrole-imidazole alkaloids using a floating chirality approach.

• DOI: 10.1021/np200514g
• 发表时间: 2012-02-24
• 期刊: Journal of natural products
• 影响因子: 5.1
• 作者: Köck M;Schmidt G;Seiple IB;Baran PS
• 通讯作者: Baran PS

Structure Elucidation of Submilligram Quantities of Natural Products - Application to Haliclamines G and H from the Arctic Marine Sponge Haliclona viscosa

• DOI: 10.5560/znb.2012-0039
• 发表时间: 2012-09-01
• 期刊: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
• 影响因子: 0.8
• 作者: Cychon, Christine;Schmidt, Gesine;Koeck, Matthias
• 通讯作者: Koeck, Matthias

Study on the absolute configuration of (―)-palau'amine

(â)-帕劳胺的绝对构型研究

• DOI: 10.1016/j.tetlet.2010.09.148
• 发表时间: 2010
• 期刊: Tetrahedron Letters
• 影响因子: 1.8
• 作者: T. Lindel;D. E. N. Jacquot;M. Zöllinger;R. B. Kinnel;S. McHugh;M. Köck
• 通讯作者: M. Köck

Further eleganolone-derived diterpenes from the brown alga Bifurcaria bifurcata

• DOI: 10.1016/j.tetlet.2011.09.128
• 发表时间: 2012-04-11
• 期刊: TETRAHEDRON LETTERS
• 影响因子: 1.8
• 作者: Goethel, Qun;Lichte, Ellen;Koeck, Matthias
• 通讯作者: Koeck, Matthias

Formyleleganolone and bibifuran, two metabolites from the brown alga Bifurcaria bifurcata

甲酰乙醇酮和比比呋喃，来自褐藻 Bifurcaria bifurcata 的两种代谢物

• DOI: 10.1016/j.phytol.2012.06.010
• 发表时间: 2012
• 期刊: Phytochemistry Letters
• 影响因子: 1.7
• 作者: Q. Göthel;J. Muñoz;M. Köck
• 通讯作者: M. Köck