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ANGIOGENESIS AND MONOCLONAL ANTIBODY UPTAKE IN MICROMETASTASES OF THE LIVER

ANGIOGENESIS AND MONOCLONAL ANTIBODY UPTAKE IN MICROMETASTASES OF THE LIVER
肝脏微转移中的血管生成和单克隆抗体摄取
批准号：
09671337
负责人：
YOSHIDA Kazuhiko
金额：
$0.83万
依托单位：
THE JIKEI UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
项目状态：
已结题
起止时间：
1997 至 1998
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671337/
关键词：
monoclonal antibodycolon cancerliver metastasis

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英文摘要
To determine the relationship between angiogenesis and monoclonal antibody (mAb) uptake in micrometastases, we made a model of hepatic micrometastases after splenic injection of human colon cancer cell (HT-29) in nude mice, and analyze the angiogenesis and mAb (H-15) uptake in the model. In micrometastases which size were between 300*600 mum, a plenty of angiogenesis was found and high accumulation of mAb was identified around newer vessels. This information is very useful to conduct clinical trials of radioimmunotherapy in adjuvant setting.
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