ANGIOGENESIS AND MONOCLONAL ANTIBODY UPTAKE IN MICROMETASTASES OF THE LIVER

为探讨微转移瘤中血管生成与单抗(MAb)摄取的关系，我们建立了人结肠癌细胞(HT-29)脾内注射裸鼠肝脏微转移模型，并对模型中血管生成和单抗(H-15)摄取进行了分析。在大小在300×600微米之间的微转移瘤中，有大量的血管生成，新血管周围有大量的mAb积聚。这些信息对在辅助环境下进行放射免疫治疗的临床试验非常有用。

To determine the relationship between angiogenesis and monoclonal antibody (mAb) uptake in micrometastases, we made a model of hepatic micrometastases after splenic injection of human colon cancer cell (HT-29) in nude mice, and analyze the angiogenesis and mAb (H-15) uptake in the model. In micrometastases which size were between 300*600 mum, a plenty of angiogenesis was found and high accumulation of mAb was identified around newer vessels. This information is very useful to conduct clinical trials of radioimmunotherapy in adjuvant setting.