SIGNIFICANCE OF 2-OXOALDEHYDE IN FOOD AND BIOLOGICAL SYSTEMS

2-氧代醛在食品和生物系统中的重要性

• 批准号: 09660146
• 负责人: HAYASE Fumitaka
• 金额: $ 1.79万
• 依托单位: MEIJI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09660146/
• 关键词: Maillard reaction; 2-oxoaldehydes; 3-deoxyglucosone; glyoxal; imidazolones; pyrropyridine; 2'-deoxyguanosine; pentosidine; メチルグリオキサール; グルコソン; ピロピリジン; 3-デキオキシグルコソン; アルギニン

1997 :(1) Glucosone (GLCO), 3-deoxyglucosone (3DG), glyoxal (GO), and methyiglyoxal (MG) were detected in the reaction systems of lysozyme-glucose (LG) and lysozyme-fructose (LF). Transition metals gave significant effects on the formation of GLCO and GO.On the other hand, oxygen was not essential for the generation of 3DG.(2) Novel imidazole compound was identified by the reaction of 3DG and N -benzoylarginine amide. Lysyl-pyrropyridine was identified in the reacton of lysozyme and reducing sugars.1998 :(1) The amounts of lysyl-pyrropyridine and pentosidine were determined in LG, LE, and L-3DG reaction systems. Lysyl-pyrropyridine increased in quantity compared to pentosidine in 3DG-lysozyme reacton systems. In LG and LF reaction systems, pentosidine increased in comparison with the formation amounts of lysyl-pyrropyridine.(2) 3DG reacted readily with 2'-deoxyguanosine in nucleosides. Two major products (G-A and G-B) were isolated and purified from the reaction mixture of 3DG and 2'-deoxyguariosine. G-A was identified as N- (1-oxo-2,4,5,6-hydroxyhexyl) -2'- deoxyguanosine. G-B was identified as a diastereomer of G-A.

1997:(1)在溶菌酶-葡萄糖（LG）和溶菌酶-果糖（LF）反应体系中检测到葡糖苷（GLCO）、3-脱氧葡糖苷（3DG）、乙二醛（GO）和甲基乙二醛（MG）。过渡金属对GLCO和GO的形成有显著影响。另一方面，氧不是生成3DG所必需的。(2)通过3DG与N -苯甲酰精氨酸酰胺反应，鉴定出新的咪唑类化合物。在溶菌酶与还原糖反应中鉴定出赖基-吡咯吡啶。1998:(1)测定了LG、LE和L-3DG反应体系中赖基-吡咯吡啶和戊苷的含量。在3d -溶菌酶反应体系中，赖基-吡咯吡啶的数量比戊苷增加。在LG和LF反应体系中，戊苷比赖基吡啶的生成量增加。(2) 3DG很容易与核苷中的2′-脱氧鸟苷反应。从3DG和2′-脱氧瓜苷的反应混合物中分离纯化了两个主要产物G-A和G-B。G-A鉴定为N-（1-氧-2,4,5,6-羟基己基）-2'-脱氧鸟苷。G-B被鉴定为G-A的非对映体。

项目成果

Fumitaka Hayase: "Recent development in the research on Maillard reaction" Recent Res.Devel.in Agric.Biol.Chem.1. 351-362 (1997)

Fumitaka Hayase：“美拉德反应研究的最新进展”Recent Res.Devel.in Agric.Biol.Chem.1。

早瀬文孝: "メイラード反応による活性酸素の生成と消去" 油化学. 46(10). 1137-1145 (1997)

Fumitaka Hayase：“通过美拉德反应产生和消除活性氧”《石油化学》46(10)。

Fumitaka Hayase: "Production and scavenging of active oxygens species by Maillard reaction" J.Japan Oil Chem.Soc.46(10). 1137-1145 (1997)

Fumitaka Hayase：“通过美拉德反应产生和清除活性氧物种”J.Japan Oil Chem.Soc.46(10)。

Fumitaka Hayase and Koji Kaneko: "Formation of N-(1-oxo-2,4,5,6-hydroxyhexyl)-2'-deoxyguanosine by the reaction of 2'-deoxyguanosine with 3-deoxyglucosone, Biosc.Biotechnol. Biochem., 62(8), 1630-1632 (1998)."

Fumitaka Hayase 和 Koji Kaneko：“通过 2-脱氧鸟苷与 3-脱氧葡萄糖酮反应形成 N-(1-氧代-2,4,5,6-羟基己基)-2-脱氧鸟苷，Biosc.Biotechnol.Biochem。

F.Hayase: "Formation of N-(1-oxo-2,4,5,6-hydroxyhexyl)-2'-deoxyguanosine by the reaction of 2'-deoxyguanosine with 3-deoxyglucosone" Biosci.Biotech.Biochem.62・8. 1630-1632 (1998)

F.Hayase：“通过2-脱氧鸟苷与3-脱氧葡萄糖醛酮的反应形成N-(1-氧代-2,4,5,6-羟基己基)-2-脱氧鸟苷” Biosci.Biotech.Biochem.62・8. 1630-1632 (1998)