How and why cells decorate their genetic messages

细胞如何以及为何修饰其遗传信息

• 批准号: DP210102385
• 负责人: Prof Thomas Preiss
• 金额: $ 52.46万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102385
• 关键词: How; why; cells; decorate; their

This project aims to investigate a new layer of genomic control mediated not by DNA but instead by chemical modifications found on the cell's working copies of genetic information called messenger RNA. The investigations will use cutting-edge RNA sequencing technology and the fruit fly model organism to uncover the scope and mechanisms by which such modifications enact their roles at the molecular level and within the body plan of an animal. Expected outcomes include novel molecular tools and models that will assist in understanding and manipulating the function of genomes. Such knowledge should provide benefits in developing innovative biotechnology applications of use in human health, agriculture and managing the environment.

该项目旨在研究一种新的基因组控制层，这种层不是由DNA介导的，而是通过在细胞中被称为信使RNA的遗传信息的工作拷贝上发现的化学修饰来介导的。研究将使用尖端的RNA测序技术和果蝇模式生物来揭示这些修饰在分子水平和动物身体计划中发挥作用的范围和机制。预期的结果包括新的分子工具和模型，将有助于理解和操纵基因组的功能。这种知识应有助于开发用于人类健康、农业和环境管理的创新生物技术应用。