Probing the cellular functions of the translation factor p97

探究翻译因子 p97 的细胞功能

• 批准号: nhmrc : 514905
• 负责人: Prof Thomas Preiss
• 金额: $ 24.69万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/probing-cellular-functions-factor-p97/98795
• 关键词: Probing; cellular; functions; translation; factor

The protein p97 takes part in the synthesis of cellular proteins from messenger RNA, a central step in gene expression. We will characterise p97 function as cells progress through their cycle of growth and division, and during responses to stress. Cellular stress is important in many diseases, such as viral infection, diabetes, heart disease, cancer, or complications during major surgery. Knowledge of p97 function may help us to better understand and treat these diseases.

蛋白p97参与信使RNA合成细胞蛋白，这是基因表达的核心步骤。我们将描述p97在细胞生长和分裂周期以及应激反应过程中的功能。细胞应激在许多疾病中都很重要，如病毒感染、糖尿病、心脏病、癌症或大手术期间的并发症。了解p97的功能可以帮助我们更好地理解和治疗这些疾病。