Determining the sequence of events during eukaryotic translation initiation

确定真核翻译起始过程中的事件顺序

• 批准号: DP0774282
• 负责人: Prof Thomas Preiss
• 金额: $ 16.32万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0774282
• 关键词: Determining; sequence; events; during; eukaryotic

Multiple benefits will arise from a more complete understanding of translation initiation. It is a frequent target for mechanisms that control gene expression and its dys-regulation is associated with human disease. For example, this is evident in cancer biology, since altered translation is a frequent cause of tumorigenesis. Translation is of universal importance for cellular function and knowledge of how it works is central to modern life sciences and its application to medical and biotechnological problems. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.

更全面地了解翻译起始过程将带来多重好处。它是控制基因表达机制的常见靶标，其失调与人类疾病有关。例如，这在癌症生物学中是很明显的，因为翻译的改变是肿瘤发生的一个常见原因。翻译对于细胞功能和它如何工作的知识是现代生命科学及其在医学和生物技术问题上的应用的核心，具有普遍的重要性。最后，更好地了解酵母细胞生物学对食品和工业生物技术部门是有益的。