Role of mRNA polyadenylation control in gene expression

mRNA 多腺苷酸化控制在基因表达中的作用

• 批准号: DP0878224
• 负责人: Prof Thomas Preiss
• 金额: $ 47.91万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0878224
• 关键词: Role; mRNA; polyadenylation; control; gene

Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce knowledge of broad relevance to modern life sciences and its applications in medicine and biotechnology. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.

对信使RNA poly（A）尾的功能有更全面的了解会带来一些好处。它经常被控制细胞蛋白质合成的机制靶向。这在发育生物学中最为明显，其中尾长控制调节母体mRNA表达。我们以前的工作表明，它对细胞功能的重要性比以前认为的要广泛得多，因此它的研究将产生与现代生命科学及其在医学和生物技术中的应用广泛相关的知识。最后，更好地了解酵母细胞生物学对食品和生物技术行业有益。