Molecular modes of microRNA-mediated gene control

microRNA介导的基因控制的分子模式

• 批准号: nhmrc : 573726
• 负责人: Prof Thomas Preiss
• 金额: $ 37.76万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-modes-microrna-gene-control/100957
• 关键词: Molecular; modes; microRNA; mediated; gene

microRNA are non-coding RNAs with fundamental functions in biology and emerging roles in disease. Hundreds of microRNA have been found and they control gene expression by destroying RNA or controlling their translation into cellular proteins. We will characterise their mechanisms of action and the cellular factors that are involved. Understanding the way microRNA work is a key question in gene regulation research and will aid the development of therapeutic strategies invovling small RNA.

microRNA是一种非编码RNA，在生物学中具有基本功能，并在疾病中发挥重要作用。已经发现了数百种microRNA，它们通过破坏RNA或控制其翻译成细胞蛋白质来控制基因表达。我们将阐明它们的作用机制和所涉及的细胞因子。了解microRNA的工作方式是基因调控研究中的一个关键问题，将有助于开发涉及小RNA的治疗策略。