Genome-wide discovery of translation control mechanisms

翻译控制机制的全基因组发现

• 批准号: DP180100111
• 负责人: Prof Thomas Preiss
• 金额: $ 33万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180100111
• 关键词: Genome; wide; discovery; translation; control

This project aims to reveal currently unknown molecular details of protein synthesis, a step of gene expression that is central to all of life. To achieve this, innovative methods based on next-generation sequencing will be deployed in the yeast model organism. Yeasts are of importance as pathogens as well as in the food and biotechnology industry sector. Thus, new knowledge generated in this project will help solve problems of invasive pathogenic behaviour and biomass production.

该项目旨在揭示目前未知的蛋白质合成的分子细节，蛋白质合成是基因表达的一个步骤，是所有生命的核心。为了实现这一点，将在酵母模式生物中部署基于下一代测序的创新方法。酵母菌是重要的病原体，在食品和生物技术行业也是如此。因此，该项目产生的新知识将有助于解决入侵致病行为和生物量生产的问题。