Marietta Community Actively Researching Exposure Study

说明(申请人提供)：锰(锰)是一种必需元素，但过量则具有神经毒性。尽管婴儿和幼儿可能比成年人有更大的锰神经毒性风险，但很少有研究评估慢性锰暴露对儿童发育的影响。俄亥俄州的玛丽埃塔是阿巴拉契亚的一个农村社区，50多年来一直是美国和加拿大唯一的金属精炼厂的所在地。作为回应，社区组成了清洁空气(NCA)的邻居。NCA已要求辛辛那提大学(UC)帮助他们了解暴露及其相关的健康影响(如果有的话)。对于这个项目，Marietta社区积极研究暴露研究(CARE)，社区定义了研究议程，确定了研究问题、目标、具体目的，并确定了社区内可用于进行研究的资源。社区成员将参与研究项目的方方面面，包括环境采样、神经行为评估、项目协调和生物标本收集。这项应用的主要目标是检查儿童接触锰的生物学指标，并了解慢性接触锰对儿童的影响。加州大学将提供环境健康研究方面的培训、监督和专业知识，以解决以下假设：与年龄匹配的低/非暴露组相比，在7-8岁的高暴露组中，儿童早期暴露于锰与神经发育缺陷显著相关。为了验证这一假设，将实现以下由社区驱动的具体目标。具体目标1：评估俄亥俄州玛丽埃塔的高锰暴露社区和俄亥俄州坎布里奇的低锰暴露社区的环境锰暴露。具体目标2：评估俄亥俄州玛丽埃塔高锰暴露社区和俄亥俄州剑桥低锰暴露社区儿童暴露于锰的神经行为影响的比较。具体目标3：评估接触锰暴露社区(俄亥俄州玛丽埃塔)和低锰暴露社区(俄亥俄州坎布里奇)对儿童神经运动影响的比较。鉴于儿童对毒物暴露的独特敏感性，以及在长期暴露的社区中研究锰暴露的机会，我们预计该项目将对与锰暴露相关的地方和国家公共卫生政策产生重大影响。项目简介：接触锰(Mn)会导致神经缺陷，全球接触MMT的潜力很大，MMT是一种抗爆剂，可取代汽油中的铅。玛丽埃塔社区积极研究暴露研究(CARE)是一项以社区为基础的研究，旨在探索儿童长期接触锰对健康的影响。与公共卫生相关：接触锰(Mn)会导致神经功能缺陷，全球接触MMT的潜力很大，MMT是一种替代汽油中铅的抗爆剂。玛丽埃塔社区积极研究暴露研究(CARE)是一项以社区为基础的研究，旨在探索儿童长期接触锰对健康的影响。

DESCRIPTION (provided by applicant): Manganese (Mn) is an essential element, yet is neurotoxic in excess. Despite the fact that infants and young children may be at greater risk for Mn neurotoxicity than adults, very few studies have evaluated the effect of chronic Mn exposure on child development. Marietta, Ohio, a rural Appalachian community, has been home to the only metal refinery in the US and Canada for over 50 years. In response, the community formed Neighbors for Clean Air (NCA). The University of Cincinnati (UC) has been asked by NCA to assist them in understanding their exposure and related health effects, if any. For this project, Marietta Community Actively Researching Exposure Study (CARES), the community has defined the research agenda, determining the research questions, objectives, specific aims and identifying resources available within the community to conduct the research. Members of the community will be engaged in all facets of the research project, including environmental sampling, neurobehavioral assessment, project coordination, and collection of biological specimens. The primary objectives of this application are to examine biological indicators of Mn exposure in children and understand the effects of chronic manganese exposure in children. UC will provide training, oversight and expertise in environmental health research, to address the following hypothesis: Exposure to Mn during early childhood is significantly associated with neurodevelopmental deficits in high exposed children ages 7-8 years compared to an age matched low/unexposed group. In order to test the hypothesis, the following community-driven specific aims will be accomplished. Specific Aim 1: Assess environmental Mn exposure within a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 2: Evaluate comparisons of the neurobehavioral effects in children exposed to Mn in a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 3: Evaluate comparisons of the neuromotor effects in children exposed to Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Given the unique susceptibility of children to toxicant exposure and the opportunity to study Mn exposure in a chronically exposed community, we anticipate this project to significantly impact local and national public health policy related to Mn exposure. Project Narrative Exposure: to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children. PUBLIC HEALTH RELEVANCE: Exposure to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children.