Administrative Core

行政核心

• 批准号: 10159860
• 负责人: Betty Diamond
• 金额: $ 7.99万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159860
• 关键词: Adherence; Advisory Committees; Autoantibodies; Autoimmunity; B-Lymphocytes; Biometry; Blood; Cells; Clinical; Clinical Data; Clinical Investigator; Clinical Trials; Collaborations; Collection; Communities; Consultations; Data; Diamond; Ensure; Goals; Immunization; Individual; Inflammatory Arthritis; Institution; Institutional Review Boards; Logistics; Lupus; Manuscripts; Pathogenesis; Pathway interactions; Patient Recruitments; Patient Selection; Patients; Pilot Projects; Plasma Cells; Principal Investigator; Production; Prognosis; Progress Reports; Protocols documentation; Regulation; Research; Research Personnel; Research Project Grants; Rheumatology; Role; Sampling; Schedule; Specimen; Systemic Lupus Erythematosus; TNF gene; Technology; Tetanus Toxoid; Time; biobank; clinical center; clinical infrastructure; clinical research site; cohesion; cohort; cross reactivity; data management; data repository; experience; individual patient; influenza virus vaccine; inhibitor/antagonist; meetings; member; novel therapeutics; organizational structure; recruit; therapeutic target; translational study

Administrative Core Project Summary The overall goal of our Autoimmunity Center of Excellence proposal is to investigate mechanisms for the production of autoantibodies that contribute to the pathogenesis of SLE. Three individual projects will examine basic questions related to initial induction of autoantibodies, the B cells that produce them, cross-reactivity and regulation of autoantibody producing B cells in patients with SLE (Principal and Pilot Projects) and in patients with inflammatory arthritis that develop lupus-related autoimmunity induced by TNF inhibitors (Collaborative Project). The Administrative Core will be central to the functioning of our ACE by providing budgetary and financial oversight, by managing interactions with the clinical investigators who will be recruiting patients for the proposed translational studies, by providing biostatistical oversight and by providing logistical support to facilitate scientific interactions within the Feinstein ACE, with collaborators and with other ACE members. The Core will be co- directed by Drs Anne Davidson and Betty Diamond who have vast experience with collaborative studies and will have complementary roles in managing interactions with collaborators. In addition, the Administrative Core will be supported by an established clinical infrastructure that includes a large patient pool, well-established patient cohorts, expert clinical collaborators, IRB approved protocols for data and blood collection, an experienced biostatistics collaborator and appropriate scientific technology. The close existing relationships between all the investigators and collaborators and with our long time administrative staff should ensure smooth functioning of the Core and successful implementation of all projects.

行政核心项目摘要 我们的自体免疫卓越中心提案的总体目标是调查 自身抗体的产生机制有助于SLE的发病。 三个单独的项目将审查与初始入职相关的基本问题 自身抗体、产生自身抗体的B细胞、自身抗体的交叉反应和调节 系统性红斑狼疮患者的B细胞产生(主要和试点项目)和 肿瘤坏死因子抑制剂诱导狼疮相关性自身免疫的炎性关节炎 (协作项目)。行政核心将是我们的ACE运作的核心，通过 通过管理与临床的交互，提供预算和财务监督 将为拟议的转译研究招募患者的研究人员，通过提供 生物统计监督，并提供后勤支持，以促进 范斯坦ACE，与合作者和其他ACE成员。核心将是联合- 由安妮·戴维森和贝蒂·戴蒙德博士执导，他们在协作方面拥有丰富的经验 研究并将在管理与合作者的互动方面发挥补充作用。在……里面 此外，行政核心将得到建立的临床基础设施的支持， 包括庞大的患者池、成熟的患者队列、专业的临床合作者、IRB 批准的数据和血液采集方案，一位经验丰富的生物统计合作者和 适当的科学技术。所有调查人员之间存在的密切关系 合作者和我们的长期行政人员应该确保顺利运作 所有项目的核心和成功实施。