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Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA

Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA
SLE 和 RA 炎症组织中非典型淋巴细胞群的起源和功能
批准号：
10598097
负责人：
Betty Diamond
金额：
$62.67万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
项目状态：
未结题
起止时间：
2021-06-15 至 2026-03-31
来源：
https://reporter.nih.gov/project-details/10598097
关键词：
AddressAgeAntibodiesAntigen-Presenting CellsAntigenic SpecificityAntigensAtypical lymphocyteAutoantibodiesAutoimmune DiseasesAutoimmunityB-Cell Antigen ReceptorB-Cell DevelopmentB-LymphocytesBLR1 geneBloodCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCell CommunicationCell SurvivalCell physiologyCellsComplement 3d ReceptorsDerivation procedureDevelopmentDiseaseExhibitsFamilyFibroblastsFrequenciesHelper-Inducer T-LymphocyteHeterogeneityHomingHumanITGAX geneImmuneImmunologicsImmunologyIn SituInfiltrationInflammatoryKidneyKnowledgeLupusLymphocyteLymphoidMapsMediatorMemory B-LymphocyteMyeloid CellsNatural Killer CellsPathogenicityPathway interactionsPatientsPeripheralPhenotypePlasma CellsPlasmablastPopulationProcessProductionResolutionRheumatoid ArthritisStromal CellsSyndromeSynovial FluidSynovial MembraneSystemSystemic Lupus ErythematosusT-LymphocyteT-Lymphocyte SubsetsTissuesWorkcandidate identificationchemokinechemokine receptorchronic autoimmune diseasecytokinedesigninterleukin-21new therapeutic targetsynergismtargeted treatmenttranscriptometranscriptomics

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英文摘要
A high-resolution analysis of cells in inflamed tissue offers the possibility of uncovering previously unappreciated pathogenic mechanisms and of identifying new therapeutic targets. In this project, we will characterize age/autoimmunity associated B cells (ABCs) in kidney and synovium of patients with systemic lupus and rheumatoid arthritis, respectively. We will explore their heterogeneity, derivation, localization, and antigenic targets as well as their functional interactions with T cell subsets, most specifically T follicular and T peripheral helper cells (Tfh/Tph). These efforts will provide a broad assessment of the features and potential functions of this highly expanded B cell population in human autoimmunity.
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Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA
  • 批准号：
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  • 项目类别：
  • 资助金额：
    $62.21万
  • 财政年份：
    2021
  • 负责人：
    Betty Diamond
  • 依托单位：
    BRIGHAM AND WOMEN'S HOSPITAL
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    BRIGHAM AND WOMEN'S HOSPITAL
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