Administrative Core
行政核心
基本信息
- 批准号:10397088
- 负责人:
- 金额:$ 9.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AdherenceAdvisory CommitteesAutoantibodiesAutoimmunityB-LymphocytesBiometryBloodCellsClinicalClinical DataClinical InvestigatorClinical TrialsCollaborationsCollectionCommunitiesConsultationsDataDiamondEnsureGoalsImmunizationIndividualInflammatory ArthritisInstitutionInstitutional Review BoardsLogisticsLupusManuscriptsPathogenesisPathway interactionsPatient RecruitmentsPatient SelectionPatientsPilot ProjectsPlasma CellsPrincipal InvestigatorProductionPrognosisProgress ReportsProtocols documentationRegulationResearchResearch PersonnelResearch Project GrantsRheumatologyRoleSamplingScheduleSpecimenSystemic Lupus ErythematosusTNF geneTechnologyTetanus ToxoidTimebiobankclinical centerclinical infrastructureclinical research sitecohesioncohortcross reactivitydata managementdata repositoryexperienceindividual patientinfluenza virus vaccineinhibitormeetingsmembernovel therapeuticsrecruittherapeutic targettranslational study
项目摘要
Administrative Core Project Summary
The overall goal of our Autoimmunity Center of Excellence proposal is to investigate
mechanisms for the production of autoantibodies that contribute to the pathogenesis of SLE.
Three individual projects will examine basic questions related to initial induction of
autoantibodies, the B cells that produce them, cross-reactivity and regulation of autoantibody
producing B cells in patients with SLE (Principal and Pilot Projects) and in patients with
inflammatory arthritis that develop lupus-related autoimmunity induced by TNF inhibitors
(Collaborative Project). The Administrative Core will be central to the functioning of our ACE by
providing budgetary and financial oversight, by managing interactions with the clinical
investigators who will be recruiting patients for the proposed translational studies, by providing
biostatistical oversight and by providing logistical support to facilitate scientific interactions within
the Feinstein ACE, with collaborators and with other ACE members. The Core will be co-
directed by Drs Anne Davidson and Betty Diamond who have vast experience with collaborative
studies and will have complementary roles in managing interactions with collaborators. In
addition, the Administrative Core will be supported by an established clinical infrastructure that
includes a large patient pool, well-established patient cohorts, expert clinical collaborators, IRB
approved protocols for data and blood collection, an experienced biostatistics collaborator and
appropriate scientific technology. The close existing relationships between all the investigators
and collaborators and with our long time administrative staff should ensure smooth functioning
of the Core and successful implementation of all projects.
行政核心项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Betty Diamond其他文献
Betty Diamond的其他文献
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{{ truncateString('Betty Diamond', 18)}}的其他基金
Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA
SLE 和 RA 炎症组织中非典型淋巴细胞群的起源和功能
- 批准号:
10088788 - 财政年份:2021
- 资助金额:
$ 9.42万 - 项目类别:
Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA
SLE 和 RA 炎症组织中非典型淋巴细胞群的起源和功能
- 批准号:
10427145 - 财政年份:2021
- 资助金额:
$ 9.42万 - 项目类别:
Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA
SLE 和 RA 炎症组织中非典型淋巴细胞群的起源和功能
- 批准号:
10598097 - 财政年份:2021
- 资助金额:
$ 9.42万 - 项目类别:
Effect of Covid-19 engagement of ACE2 on brain health and pathology
Covid-19 与 ACE2 的结合对大脑健康和病理学的影响
- 批准号:
10151985 - 财政年份:2020
- 资助金额:
$ 9.42万 - 项目类别:
Alteration of function and specificity of TFH in SLE
SLE 中 TFH 功能和特异性的改变
- 批准号:
9973185 - 财政年份:2019
- 资助金额:
$ 9.42万 - 项目类别:
Alteration of function and specificity of TFH in SLE
SLE 中 TFH 功能和特异性的改变
- 批准号:
10650347 - 财政年份:2019
- 资助金额:
$ 9.42万 - 项目类别:
Alteration of function and specificity of TFH in SLE
SLE 中 TFH 功能和特异性的改变
- 批准号:
10196943 - 财政年份:2019
- 资助金额:
$ 9.42万 - 项目类别:
Alteration of function and specificity of TFH in SLE
SLE 中 TFH 功能和特异性的改变
- 批准号:
10437692 - 财政年份:2019
- 资助金额:
$ 9.42万 - 项目类别:
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