Administrative Core

行政核心

• 批准号: 10617661
• 负责人: Betty Diamond
• 金额: $ 39.51万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10617661
• 关键词: Adherence; Advisory Committees; Autoantibodies; Autoimmunity; B-Lymphocytes; Biometry; Blood; Cells; Clinical; Clinical Data; Clinical Investigator; Clinical Trials; Collaborations; Collection; Communities; Consultations; Data; Diamond; Ensure; Goals; Immunization; Individual; Inflammatory Arthritis; Institution; Institutional Review Boards; Lupus; Manuscripts; Pathogenesis; Pathway interactions; Patient Recruitments; Patient Selection; Patients; Pilot Projects; Plasma Cells; Principal Investigator; Production; Prognosis; Progress Reports; Protocols documentation; Regulation; Research; Research Personnel; Research Project Grants; Rheumatology; Role; Sampling; Schedule; Specimen; Systemic Lupus Erythematosus; TNF gene; Technology; Tetanus Toxoid; Time; biobank; clinical center; clinical infrastructure; clinical research site; cohesion; cohort; cross reactivity; data management; data repository; experience; individual patient; influenza virus vaccine; inhibitor; meetings; member; novel therapeutics; patient retention; recruit; therapeutic target; translational study

Administrative Core Project Summary The overall goal of our Autoimmunity Center of Excellence proposal is to investigate mechanisms for the production of autoantibodies that contribute to the pathogenesis of SLE. Three individual projects will examine basic questions related to initial induction of autoantibodies, the B cells that produce them, cross-reactivity and regulation of autoantibody producing B cells in patients with SLE (Principal and Pilot Projects) and in patients with inflammatory arthritis that develop lupus-related autoimmunity induced by TNF inhibitors (Collaborative Project). The Administrative Core will be central to the functioning of our ACE by providing budgetary and financial oversight, by managing interactions with the clinical investigators who will be recruiting patients for the proposed translational studies, by providing biostatistical oversight and by providing logistical support to facilitate scientific interactions within the Feinstein ACE, with collaborators and with other ACE members. The Core will be co- directed by Drs Anne Davidson and Betty Diamond who have vast experience with collaborative studies and will have complementary roles in managing interactions with collaborators. In addition, the Administrative Core will be supported by an established clinical infrastructure that includes a large patient pool, well-established patient cohorts, expert clinical collaborators, IRB approved protocols for data and blood collection, an experienced biostatistics collaborator and appropriate scientific technology. The close existing relationships between all the investigators and collaborators and with our long time administrative staff should ensure smooth functioning of the Core and successful implementation of all projects.

行政核心项目摘要 我们自身免疫卓越中心建议的总体目标是调查 产生自身抗体的机制，导致SLE的发病机理。 三个单独的项目将研究与初步诱导有关的基本问题 自身抗体，产生它们的B细胞，自身抗体的交叉反应性和调节 在患有SLE（主要和试点项目）的患者中产生B细胞 TNF抑制剂诱导的与狼疮相关的自身免疫性的炎症性关节炎 （协作项目）。行政核心将是我们ACE运作的核心 通过管理与临床的互动来提供预算和财务监督 通过提供的调查人员将招募患者进行拟议的翻译研究 生物统计学的监督并提供后勤支持以促进科学互动 Feinstein Ace与合作者以及其他ACE成员。核心将是共同的 由安妮·戴维森（Anne Davidson）博士和贝蒂·戴蒙德（Betty Diamond）执导，他们在合作方面拥有丰富的经验 研究并将在管理与合作者的互动中具有互补的作用。在 此外，行政核心将得到既定的临床基础设施的支持 包括一个大的患者池，成熟的患者同伙，专家临床合作者，IRB 批准的数据和血液收集方案，经验丰富的生物统计学合作者和 适当的科学技术。所有调查人员之间的现有关系 以及合作者以及我们长期的行政人员应确保正常运作 所有项目的核心和成功实施。