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Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA

Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA
SLE 和 RA 炎症组织中非典型淋巴细胞群的起源和功能
批准号：
10088788
负责人：
Betty Diamond
金额：
$62.21万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
项目状态：
未结题
起止时间：
2021-06-15 至 2026-03-31
来源：
https://reporter.nih.gov/project-details/10088788
关键词：
AddressAgeAntibodiesAntigen-Presenting CellsAntigenic SpecificityAntigensAtypical lymphocyteAutoantibodiesAutoimmune DiseasesAutoimmunityB-Cell Antigen ReceptorB-Cell DevelopmentB-LymphocytesBLR1 geneBloodCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCell SurvivalCell physiologyCellsComplement 3d ReceptorsDerivation procedureDevelopmentDiseaseExhibitsFamilyFibroblastsFrequenciesHelper-Inducer T-LymphocyteHeterogeneityHomingHumanITGAX geneImmuneImmunologicsImmunologyIn SituKidneyKnowledgeLupusLymphocyteLymphoidMapsMediator of activation proteinMemory B-LymphocyteMyeloid CellsNatural Killer CellsPathogenicityPathway interactionsPatientsPeripheralPhenotypePlasma CellsPlasmablastPopulationProcessProductionResolutionRheumatoid ArthritisStromal CellsSyndromeSynovial FluidSynovial MembraneSystemSystemic Lupus ErythematosusT-LymphocyteT-Lymphocyte SubsetsTissuesWorkchemokinechemokine receptorchronic autoimmune diseasecytokinedesignnew therapeutic targetsynergismtargeted treatmenttranscriptometranscriptomics

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中文摘要
翻译
对炎症组织中细胞的高分辨率分析提供了揭示先前的可能性
英文摘要
A high-resolution analysis of cells in inflamed tissue offers the possibility of uncovering previously unappreciated pathogenic mechanisms and of identifying new therapeutic targets. In this project, we will characterize age/autoimmunity associated B cells (ABCs) in kidney and synovium of patients with systemic lupus and rheumatoid arthritis, respectively. We will explore their heterogeneity, derivation, localization, and antigenic targets as well as their functional interactions with T cell subsets, most specifically T follicular and T peripheral helper cells (Tfh/Tph). These efforts will provide a broad assessment of the features and potential functions of this highly expanded B cell population in human autoimmunity.
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Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA
  • 批准号：
    10427145
  • 项目类别：
  • 资助金额：
    $49.84万
  • 财政年份：
    2021
  • 负责人：
    Betty Diamond
  • 依托单位：
    BRIGHAM AND WOMEN'S HOSPITAL
Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA
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    BRIGHAM AND WOMEN'S HOSPITAL
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