Systems Technologies Core

摘要-系统技术核心 系统技术核心（STC）的总体目标是提供专业知识， 仪器和新颖的分析方法来解决提出的广泛科学问题 在北卡罗来纳州州立大学的人类健康和环境中心（CHHE）。专门知识 分析评估是非常需要的，以翻译的CHHE的使命，以了解人类如何 健康受到环境因素的影响，并实施这些知识，以减少 环境因素STC将为CHHE研究人员提供分析专业知识和最新技术 方法，以创建一个综合的，机械的图片的潜在影响的环境 对人体健康的影响。这些方法包括1）基因组学，转录组学和表观基因组学; 2） 发现和靶向蛋白质组学：3）发现和靶向代谢组学，包括环境毒物; 4）金属组学，包括金属形态。STC的每个部分都将有一位专家导航员：Erin博士 贝克-代谢组学/小分子;大卫Baltzegar博士-基因组学，表观基因组学转录组学; Michael Bereman-蛋白质组学;和Dean Hesterberg博士-金属组学，提供专业知识，指导， 关于尖端组学技术实验设计的咨询。为了适应分析 为了满足CHHE成员的需求，与北卡罗来纳州的测量，教育，培训部门建立了伙伴关系 和研究创新中心（METRIC）在2018年9月的蛋白质组学，代谢组学和金属组学 服务CHHE正式会员将优先使用这些设施和服务，并有资格 参加CHHE的新STC项目，我们将在下一个资助周期推出。根据本 计划，CHHE将提供50%的成本STC服务的正式成员的项目与EHS 本案无关STC与北卡罗来纳州的生物信息学研究中心（BRC）相连，所有STC数据都被传输到 并存储在BRC和CHHE支持的服务器上。STC可以使用以下方法为研究者分析数据： 专用软件或由CHHE在IHSFC内的新环境数据科学小组使用 专用的、最先进的并行计算集群，包括高功率计算节点、高内存 节点和Web服务器。

ABSTRACT- SYSTEMS TECNOLOGIES CORE The overall objective of the Systems Technologies Core (STC) is to provide expertise, state-of-the-art instrumentation and novel analytical approaches to address a broad range of scientific questions presented across the Center for Human Health and the Environment (CHHE) at NC State University. Expertise in analytical evaluations is greatly needed for the translation of the CHHE’s mission to understand how human health is impacted by environmental factors and implement this knowledge to reduce the adverse impact of environmental factors. The STC will provide CHHE investigators with analytical expertise and state-of-art methodologies to create an integrative, mechanistic picture of the underlying effects of environmental exposures on human health. These methodologies include 1) genomics, transcriptomics, and epigenomics; 2) discovery and targeted proteomics; 3) discovery and targeted metabolomics including environmental toxicants; and 4) metallomics including metal speciation. Each section of the STC will have an expert Navigator: Dr. Erin Baker - metabolomics/small molecules; Dr. David Baltzegar - genomics, epigenomics transcriptomics; Dr. Michael Bereman - proteomics; and Dr. Dean Hesterberg - metallomics to provide expertise, guidance, and consultation on experimental design for cutting-edge omics technologies. To accommodate the analytical needs of the CHHE membership, a partnership was formed with NC State’s Measurement, Education, Training and Research Innovation Center (METRIC) in September 2018 for proteomics, metabolomics, and metallomics services. CHHE Full members will have priority access to these facilities and services and will be eligible to participate in CHHE’s new STC Voucher Program which we will launch in the next funding cycle. Under this program, CHHE will provide 50% of the costs for STC services to Full members for projects with EHS relevance. STC is linked to NC State’s Bioinformatics Research Center (BRC) and all STC data are transferred and stored on BRC- and CHHE-supported servers. Data can be analyzed for investigators by the STC using dedicated software or by CHHE’s new Environmental Data Science Group within the IHSFC utilizing a dedicated, state-of-the-art parallel computing cluster that includes high-power compute nodes, high-memory nodes and web servers.