Sulfoxide Polymers - A New Paradigm in Polymer Design

低结垢聚合物对于缓和分子和颗粒与细胞的相互作用是重要的。在制药科学中，它们是延长溶解药物的药代动力学的重要工具。然而，广泛使用的低污染聚合物，聚（乙二醇）（PEG）最近已被报道诱导形成抗PEG抗体。因此迫切需要PEG的聚合物替代品。在这个项目中，我们介绍了超亲水聚合物纳入亚砜基团，模拟极性溶剂DMSO。该项目旨在探索聚合物结构如何增强生物相容性并减少生物污染。其结果将是一类新的低污染聚合物材料，在生物科学中具有广泛的应用。

Low fouling polymers are important for moderating interactions of molecules and particles with cells. In pharmaceutical sciences they are essential tools for extending the pharmacokinetics of dissolved drugs. However, the widely-used low-fouling polymer, poly(ethylene glycol) (PEG) has been recently reported to induce formation of anti-PEG antibodies. Polymeric alternatives to PEG are thus desperately needed. We introduce in this project super-hydrophilic polymers incorporating sulfoxide groups, mimics of the polar solvent DMSO. The project aims to explore how polymer architecture can enhance biocompatibility and reduce biofouling. The outcome will be a new class of low-fouling polymeric materials with broad application in the biosciences.