Sulfoxide Polymers - A New Paradigm in Polymer Design

亚砜聚合物——聚合物设计的新范式

• 批准号: DP210101496
• 负责人: Prof Andrew Whittaker
• 金额: $ 33.14万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101496
• 关键词: Sulfoxide; Polymers; New; Paradigm; Polymer

Low fouling polymers are important for moderating interactions of molecules and particles with cells. In pharmaceutical sciences they are essential tools for extending the pharmacokinetics of dissolved drugs. However, the widely-used low-fouling polymer, poly(ethylene glycol) (PEG) has been recently reported to induce formation of anti-PEG antibodies. Polymeric alternatives to PEG are thus desperately needed. We introduce in this project super-hydrophilic polymers incorporating sulfoxide groups, mimics of the polar solvent DMSO. The project aims to explore how polymer architecture can enhance biocompatibility and reduce biofouling. The outcome will be a new class of low-fouling polymeric materials with broad application in the biosciences.

低污垢聚合物对于调节分子和颗粒与细胞的相互作用很重要。在制药科学中，它们是延长溶解药物的药代动力学的必要工具。然而，最近有报道称，广泛使用的低污染聚合物聚乙二醇(PEGO)可诱导产生抗聚乙二醇单抗。因此，迫切需要聚乙二醇酯的聚合物替代品。在这个项目中，我们介绍了含有亚砜基团的超亲水聚合物，模拟了极性溶剂DMSO。该项目旨在探索聚合物建筑如何增强生物兼容性和减少生物污垢。这将是一种在生物科学中具有广泛应用的新型低污染聚合物材料。