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Covid-related changes in Taste Epithelium

味觉上皮细胞与新冠病毒相关的变化

基本信息

批准号：
10175313
负责人：
Thomas E Finger
金额：
$ 19.14万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2021-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10175313
关键词：
2019-nCoV Address Affect Anatomy Antibodies Binding Sites Biochemical Biopsy Buffers COVID-19 Centers for Disease Control and Prevention (U.S.)Collaborations Colorado Coronavirus Coughing Diagnosis Disease Double-Blind Method Dysgeusia Epithelial Epithelium Fever Formalin Functional disorder Fungiform Papilla Germany Guidelines Histologic Hour Human Infection Modality Molecular Morphology Nerve Oral mucous membrane structure Palate Pathology Patient Self-Report Patients Prevalence Procedures Psychophysics Recommendation Research Research Personnel Residual state Sampling Smell Perception Swab Symptoms Synapses Taste Buds Taste Disorders Taste Perception Testing Tissues Tongue Universities Viral Proteins Virus Virus Latency acute infection associated symptom base clinical Diagnosis coronavirus disease design experimental study receptor sample fixation screening

项目摘要

PROJECT SUMMARY Disruption of the sense of taste is a common feature of COVID-19. The proposed supplement will investigate potential histopathological changes in taste buds and the surrounding epithelium of the tongue in patients who have lost their sense of taste during COVID-19. Biopsies of fungiform papillae will be obtained from a taste center in Germany which shall conduct psychophysical testing prior to sampling 4 fungiform papillae from patients recovering from COVID-19 – either with or without taste loss. We will analyze these samples molecularly and histologically to test for presence of residual virus and for changes in taste bud number, morphology or cellular composition.

项目总结味觉受阻是新冠肺炎的一个常见特征。拟议的补编将调查慢性阻塞性肺疾病患者味蕾及舌周上皮潜在的组织病理学改变在吃新冠肺炎时失去了味觉。真菌样乳头的活组织检查将从一种味道中获得该中心将在采样4个菌状乳头之前进行心理物理测试新冠肺炎恢复期的患者--有或没有味觉丧失。我们将分析这些样品从分子和组织学上测试残留病毒的存在和味蕾数量的变化，形态或细胞组成。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex.

DOI：
10.1126/scisignal.aao1815
发表时间：
2018-05-08
期刊：
Science signaling
影响因子：
7.3
作者：
Romanov RA;Lasher RS;High B;Savidge LE;Lawson A;Rogachevskaja OA;Zhao H;Rogachevsky VV;Bystrova MF;Churbanov GD;Adameyko I;Harkany T;Yang R;Kidd GJ;Marambaud P;Kinnamon JC;Kolesnikov SS;Finger TE
通讯作者：
Finger TE

Immunohistochemical Analysis of Human Vallate Taste Buds.

人类 Vallate 味蕾的免疫组织化学分析。