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Covid-related changes in Taste Epithelium

Covid-related changes in Taste Epithelium
味觉上皮细胞与新冠病毒相关的变化
批准号：
10175313
负责人：
Thomas E Finger
金额：
$19.14万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
已结题
起止时间：
2020-07-01 至 2021-06-30
来源：
https://reporter.nih.gov/project-details/10175313
关键词：
2019-nCoVAddressAffectAnatomyAntibodiesBinding SitesBiochemicalBiopsyBuffersCOVID-19Centers for Disease Control and Prevention (U.S.)CollaborationsColoradoCoronavirusCoughingDiagnosisDiseaseDouble-Blind MethodDysgeusiaEpithelialEpitheliumFeverFormalinFunctional disorderFungiform PapillaGermanyGuidelinesHistologicHourHumanInfectionModalityMolecularMorphologyNerveOral mucous membrane structurePalatePathologyPatient Self-ReportPatientsPrevalenceProceduresPsychophysicsRecommendationResearchResearch PersonnelResidual stateSamplingSmell PerceptionSwabSymptomsSynapsesTaste BudsTaste DisordersTaste PerceptionTestingTissuesTongueUniversitiesViral ProteinsVirusVirus Latencyacute infectionassociated symptombaseclinical Diagnosiscoronavirus diseasedesignexperimental studyreceptorsample fixationscreening

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中文摘要
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英文摘要
PROJECT SUMMARY Disruption of the sense of taste is a common feature of COVID-19. The proposed supplement will investigate potential histopathological changes in taste buds and the surrounding epithelium of the tongue in patients who have lost their sense of taste during COVID-19. Biopsies of fungiform papillae will be obtained from a taste center in Germany which shall conduct psychophysical testing prior to sampling 4 fungiform papillae from patients recovering from COVID-19 – either with or without taste loss. We will analyze these samples molecularly and histologically to test for presence of residual virus and for changes in taste bud number, morphology or cellular composition.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex.
DOI： 10.1126/scisignal.aao1815
发表时间： 2018-05-08
期刊： Science signaling
影响因子： 7.3
作者： [Romanov RA, Lasher RS, High B, Savidge LE, Lawson A, Rogachevskaja OA, Zhao H, Rogachevsky VV, Bystrova MF, Churbanov GD, Adameyko I, Harkany T, Yang R, Kidd GJ, Marambaud P, Kinnamon JC, Kolesnikov SS, Finger TE]
通讯作者： Finger TE
Immunohistochemical Analysis of Human Vallate Taste Buds.
人类 Vallate 味蕾的免疫组织化学分析。
DOI： 10.1093/chemse/bjv048
发表时间： 2015
期刊： Chemical senses
影响因子： 3.5
作者： [Tizzano,Marco, Grigereit,Laura, Shultz,Nicole, Clary,MatthewS, Finger,ThomasE]
通讯作者： Finger,ThomasE
Scanning Blockface EM of Murine and Human Taste Buds
  • 批准号：
    9088450
  • 项目类别：
  • 资助金额：
    $32.98万
  • 财政年份：
    2015
  • 负责人：
    Thomas E Finger
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
Scanning Blockface EM of Murine and Human Taste Buds
  • 批准号：
    8945499
  • 项目类别：
  • 资助金额：
    $33.78万
  • 财政年份：
    2015
  • 负责人：
    Thomas E Finger
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
Scanning Blockface EM of Murine and Human Taste Buds
  • 批准号：
    9813048
  • 项目类别：
  • 资助金额：
    $3.95万
  • 财政年份：
    2015
  • 负责人：
    Thomas E Finger
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
Scanning Blockface 3D EM of taste buds: a new window into functional organization
  • 批准号：
    8611806
  • 项目类别：
  • 资助金额：
    $19.26万
  • 财政年份：
    2013
  • 负责人：
    Thomas E Finger
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
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