Covid-related changes in Taste Epithelium
味觉上皮细胞与新冠病毒相关的变化
基本信息
- 批准号:10175313
- 负责人:
- 金额:$ 19.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2021-06-30
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAddressAffectAnatomyAntibodiesBinding SitesBiochemicalBiopsyBuffersCOVID-19Centers for Disease Control and Prevention (U.S.)CollaborationsColoradoCoronavirusCoughingDiagnosisDiseaseDouble-Blind MethodDysgeusiaEpithelialEpitheliumFeverFormalinFunctional disorderFungiform PapillaGermanyGuidelinesHistologicHourHumanInfectionModalityMolecularMorphologyNerveOral mucous membrane structurePalatePathologyPatient Self-ReportPatientsPrevalenceProceduresPsychophysicsRecommendationResearchResearch PersonnelResidual stateSamplingSmell PerceptionSwabSymptomsSynapsesTaste BudsTaste DisordersTaste PerceptionTestingTissuesTongueUniversitiesViral ProteinsVirusVirus Latencyacute infectionassociated symptombaseclinical Diagnosiscoronavirus diseasedesignexperimental studyreceptorsample fixationscreening
项目摘要
PROJECT SUMMARY
Disruption of the sense of taste is a common feature of COVID-19. The proposed supplement will investigate
potential histopathological changes in taste buds and the surrounding epithelium of the tongue in patients who
have lost their sense of taste during COVID-19. Biopsies of fungiform papillae will be obtained from a taste
center in Germany which shall conduct psychophysical testing prior to sampling 4 fungiform papillae from
patients recovering from COVID-19 – either with or without taste loss. We will analyze these samples
molecularly and histologically to test for presence of residual virus and for changes in taste bud number,
morphology or cellular composition.
项目总结
味觉受阻是新冠肺炎的一个常见特征。拟议的补编将调查
慢性阻塞性肺疾病患者味蕾及舌周上皮潜在的组织病理学改变
在吃新冠肺炎时失去了味觉。真菌样乳头的活组织检查将从一种味道中获得
该中心将在采样4个菌状乳头之前进行心理物理测试
新冠肺炎恢复期的患者--有或没有味觉丧失。我们将分析这些样品
从分子和组织学上测试残留病毒的存在和味蕾数量的变化,
形态或细胞组成。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex.
- DOI:10.1126/scisignal.aao1815
- 发表时间:2018-05-08
- 期刊:
- 影响因子:7.3
- 作者:Romanov RA;Lasher RS;High B;Savidge LE;Lawson A;Rogachevskaja OA;Zhao H;Rogachevsky VV;Bystrova MF;Churbanov GD;Adameyko I;Harkany T;Yang R;Kidd GJ;Marambaud P;Kinnamon JC;Kolesnikov SS;Finger TE
- 通讯作者:Finger TE
Immunohistochemical Analysis of Human Vallate Taste Buds.
人类 Vallate 味蕾的免疫组织化学分析。
- DOI:10.1093/chemse/bjv048
- 发表时间:2015
- 期刊:
- 影响因子:3.5
- 作者:Tizzano,Marco;Grigereit,Laura;Shultz,Nicole;Clary,MatthewS;Finger,ThomasE
- 通讯作者:Finger,ThomasE
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Thomas E Finger的其他文献
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{{ truncateString('Thomas E Finger', 18)}}的其他基金
Scanning Blockface EM of Murine and Human Taste Buds
扫描小鼠和人类味蕾的块面电镜
- 批准号:
9088450 - 财政年份:2015
- 资助金额:
$ 19.14万 - 项目类别:
Scanning Blockface EM of Murine and Human Taste Buds
扫描小鼠和人类味蕾的块面电镜
- 批准号:
8945499 - 财政年份:2015
- 资助金额:
$ 19.14万 - 项目类别:
Scanning Blockface EM of Murine and Human Taste Buds
扫描小鼠和人类味蕾的块面电镜
- 批准号:
9813048 - 财政年份:2015
- 资助金额:
$ 19.14万 - 项目类别:
Scanning Blockface 3D EM of taste buds: a new window into functional organization
扫描味蕾的 Blockface 3D EM:了解功能组织的新窗口
- 批准号:
8611806 - 财政年份:2013
- 资助金额:
$ 19.14万 - 项目类别:
Scanning Blockface 3D EM of taste buds: a new window into functional organization
扫描味蕾的 Blockface 3D EM:了解功能组织的新窗口
- 批准号:
8497395 - 财政年份:2013
- 资助金额:
$ 19.14万 - 项目类别:
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