Coronary artery cross-sectional area and cardiovascular risk in South Asians

南亚人的冠状动脉横截面积和心血管风险

• 批准号: 10176172
• 负责人: ALKA M. KANAYA
• 金额: $ 12.19万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176172
• 关键词: Abdomen; African American; Age; Americas; Angiography; Area; Atherosclerosis; Bangladesh; Biological; Biological Markers; Biometry; Blood Vessels; Body Size; Body fat; Body mass index; Caliber; California; Cardiac; Cardiovascular Diseases; Cardiovascular system; Categories; Clinical Investigator; Complement; Coronary; Coronary Artery Risk Development in Young Adults Study; Coronary Stenosis; Coronary artery; DNA Methylation; Data; Development Plans; Diabetes Mellitus; Dyslipidemias; Enrollment; Epidemiology; Epigenetic Process; Ethnic group; Etiology; Event; Fatty acid glycerol esters; Funding; Future; Genetic; Genetic Risk; Geographic Locations; Goals; Grant; Hepatic; High Prevalence; Hypertension; India; Individual; Infrastructure; Internal Medicine; Knowledge; Link; Lipoprotein (a); Liver; Longitudinal Studies; Measures; Mediator of activation protein; Medicine; Mentors; Minority Groups; Modeling; Multi-Ethnic Study of Atherosclerosis; National Heart, Lung, and Blood Institute; Nepal; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pakistan; Participant; Pathogenicity; Pattern; Pericardial body location; Phase; Phenotype; Prevalence; Prevention; Prospective cohort study; Race; Research; Resources; Risk Factors; San Francisco; Slice; Smoking; South Asian; Sri Lanka; TNF gene; Thinness; Time; Training; United States National Institutes of Health; Universities; Ursidae Family; Visceral; Visceral fat; Woman; X-Ray Computed Tomography; adiponectin; aged; atherosclerosis risk; attenuation; cardiometabolic risk; cardiometabolism; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular risk factor; career development; caucasian American; clinical risk; cohort; coronary artery calcium; coronary calcium scoring; coronary plaque; design; ethnic disparity; ethnic minority population; follow-up; genetic variant; heart imaging; high risk; high risk population; male; men; methylation biomarker; methylation pattern; multidisciplinary; novel; patient oriented research; professor; prognostic significance; programs; prospective; research and development; resistin; response; sex; social culture; trait

PROJECT SUMMARY/ABSTRACT Dr. Alka Kanaya is Professor in the Departments of Medicine, Epidemiology and Biostatistics at the University of California San Francisco. Trained in Internal Medicine and Epidemiology, over the past decade she has mentored several individuals at different levels in their training and developed a thriving program of multidisciplinary collaborative research focused on cardiovascular disease epidemiology and prevention. She is currently funded by the NHLBI to conduct a prospective cohort study of South Asians called the MASALA study which is modeled on the existing Multi-Ethnic Study of Atherosclerosis (MESA) to understand the antecedents of cardiovascular disease in this high risk ethnic group. With the support of the K24 renewal, Dr. Kanaya will extend the research program by adding measures of coronary artery cross-sectional area to further knowledge on atherosclerosis markers and ASCVD. The Overall Aims of this K24 proposal are: (1) To measure coronary artery size (cross-sectional area and diameter) among 500 South Asians (age 45-65 years) in the MASALA study and describe coronary artery size by age, sex, and CAC category. (2) To compare coronary size of similar aged South Asians in MASALA with Whites and African Americans in CARDIA after adjusting for age, sex, body mass index and cardiovascular risk factors. (3) To determine the association between coronary artery size in South Asians with known cardiovascular risk factors, ectopic fat distribution, and biomarkers. (4) To determine whether previously discovered genetic variants and local methylation patterns for cardiometabolic traits generalize to South Asians, and then to investigate the association between common genetic variants and DNA methylation patterns with coronary artery size. The K24 would insure sufficient time to pursue this next phase in Dr. Kanaya's research while protecting time to devote to mentoring future clinical investigators in patient-oriented research. The plans for development, research, and mentoring were designed to complement each other and to create a synergistic effect of mentoring and research in patient-oriented research. The proposed mentoring, research, and career development activities actively leverage existing infrastructure, resources, and training initiatives provided by NIH including the CTSI, and Dr. Kanaya's active research program at UCSF.

项目摘要/摘要 Alka Kanaya博士是大学医学，流行病学和生物统计学系的教授 加利福尼亚旧金山在过去的十年中，接受过内科和流行病学的培训 指导了几个在培训中的不同级别的人，并制定了一个繁荣的计划 多学科合作研究的重点是心血管疾病流行病学和预防。她 目前由NHLBI资助，用于对南亚人进行的前瞻性队列研究，称为Masala 基于现有的动脉粥样硬化多民族研究（MESA）的研究以了解 在这个高风险族群中，心血管疾病的先例。在K24更新的支持下 卡纳亚（Kanaya）将通过增加冠状动脉横截面区域的措施来扩展研究计划 关于动脉粥样硬化标记和ASCVD的知识。 该K24提案的总体目的是：（1）测量冠状动脉大小（横截面区域和 直径）在Masala研究中的500个南亚人（45-65岁）中描述冠状动脉大小 按年龄，性别和CAC类别。 （2）比较马萨拉类似的南亚人的冠状动脉大小 调整年龄，性别，体重指数和心血管后，白人和非裔美国人 风险因素。 （3）确定南亚人与已知的冠状动脉大小之间的关联 心血管危险因素，异位脂肪分布和生物标志物。 （4）确定是否以前 发现心脏代谢特征的遗传变异和局部甲基化模式推广到南方 亚洲人，然后研究常见遗传变异与DNA甲基化之间的关联 具有冠状动脉大小的模式。 K24将为Kanaya博士的研究中的下一阶段提供足够的时间，同时保护时间 致力于指导未来的临床研究人员，以患者为导向的研究。开发计划， 研究和指导旨在相互补充，并创造协同作用 面向患者的研究的指导和研究。拟议的指导，研究和职业 开发活动积极利用由现有的基础设施，资源和培训计划提供的 NIH在内，包括CTSI，以及Kanaya博士在UCSF的活跃研究计划。