Coronary artery cross-sectional area and cardiovascular risk in South Asians

项目概要/摘要 博士Alka Kanaya是该大学医学、流行病学和生物统计学系的教授 位于加州旧金山弗朗西斯科。在过去的十年里，她接受了内科和流行病学的培训， 指导了几个人在不同层次的培训，并制定了一个蓬勃发展的计划， 多学科合作研究，重点是心血管疾病的流行病学和预防。她 目前由NHLBI资助进行一项名为MASALA的南亚人前瞻性队列研究。 这项研究是仿照现有的多民族研究动脉粥样硬化（梅萨），以了解 心血管疾病的前因在这个高风险的种族群体。在K24更新的支持下，博士。 Kanaya将通过增加冠状动脉横截面积的测量来扩展研究计划， 了解动脉粥样硬化标志物和ASCVD。 本K24提案的总体目标是：（1）测量冠状动脉大小（横截面积和 直径），并描述冠状动脉大小 按年龄性别和CAC分类(2)比较MASALA年龄相似的南亚人的冠状动脉大小， 调整年龄、性别、体重指数和心血管疾病后，CARDIA中的白人和非洲裔美国人 危险因素(3)为了确定南亚人冠状动脉大小与已知的 心血管危险因素、异位脂肪分布和生物标志物。(4)以确定先前是否 发现的心脏代谢特征的遗传变异和局部甲基化模式可推广到南方 亚洲人，进而调查常见遗传变异与DNA甲基化之间的关联 冠状动脉大小的模式。 K24将确保有足够的时间进行Kanaya博士的下一阶段研究，同时保护时间 致力于指导未来的临床研究人员进行以患者为导向的研究。发展计划， 研究和指导的目的是相辅相成，并创造一个协同效应， 指导和研究以病人为导向的研究。建议的指导，研究和职业生涯 开发活动积极利用现有的基础设施、资源和培训计划， 包括CTSI在内的NIH，以及Kanaya博士在UCSF的积极研究计划。

PROJECT SUMMARY/ABSTRACT Dr. Alka Kanaya is Professor in the Departments of Medicine, Epidemiology and Biostatistics at the University of California San Francisco. Trained in Internal Medicine and Epidemiology, over the past decade she has mentored several individuals at different levels in their training and developed a thriving program of multidisciplinary collaborative research focused on cardiovascular disease epidemiology and prevention. She is currently funded by the NHLBI to conduct a prospective cohort study of South Asians called the MASALA study which is modeled on the existing Multi-Ethnic Study of Atherosclerosis (MESA) to understand the antecedents of cardiovascular disease in this high risk ethnic group. With the support of the K24 renewal, Dr. Kanaya will extend the research program by adding measures of coronary artery cross-sectional area to further knowledge on atherosclerosis markers and ASCVD. The Overall Aims of this K24 proposal are: (1) To measure coronary artery size (cross-sectional area and diameter) among 500 South Asians (age 45-65 years) in the MASALA study and describe coronary artery size by age, sex, and CAC category. (2) To compare coronary size of similar aged South Asians in MASALA with Whites and African Americans in CARDIA after adjusting for age, sex, body mass index and cardiovascular risk factors. (3) To determine the association between coronary artery size in South Asians with known cardiovascular risk factors, ectopic fat distribution, and biomarkers. (4) To determine whether previously discovered genetic variants and local methylation patterns for cardiometabolic traits generalize to South Asians, and then to investigate the association between common genetic variants and DNA methylation patterns with coronary artery size. The K24 would insure sufficient time to pursue this next phase in Dr. Kanaya's research while protecting time to devote to mentoring future clinical investigators in patient-oriented research. The plans for development, research, and mentoring were designed to complement each other and to create a synergistic effect of mentoring and research in patient-oriented research. The proposed mentoring, research, and career development activities actively leverage existing infrastructure, resources, and training initiatives provided by NIH including the CTSI, and Dr. Kanaya's active research program at UCSF.