Coronary artery cross-sectional area and cardiovascular risk in South Asians

项目摘要/摘要 Alka Kanaya博士是该大学医学、流行病学和生物统计学系的教授 来自加利福尼亚州旧金山。在过去的十年里，她接受了内科和流行病学的培训 在他们的培训中指导了几个不同级别的人，并制定了一个蓬勃发展的计划 多学科合作研究的重点是心血管疾病流行病学和预防。她 目前由NHLBI资助，对南亚人进行一项名为Masala的前瞻性队列研究 这项研究是以现有的动脉粥样硬化多种族研究(MESA)为模型进行的，以了解 在这一高危民族中，心血管疾病的先证者。在K24更新的支持下，Dr。 Kanaya将通过增加冠状动脉横截面积的测量来扩展研究计划，以进一步 动脉粥样硬化标记物和ASCVD的知识。 本K24提案的总体目标是：(1)测量冠状动脉大小(横截面积和 MASALA研究中500名南亚人(年龄45-65岁)的冠状动脉直径)，并描述冠状动脉大小 按年龄、性别和CAC类别分类。(2)比较马萨拉地区年龄相近的南亚人的冠状动脉大小。 在对年龄、性别、体重指数和心血管疾病进行调整后，CARDIA中的白人和非裔美国人 风险因素。(3)确定南亚人的冠状动脉大小与已知的 心血管危险因素、异位脂肪分布和生物标志物。(4)确定之前是否 心脏代谢性状的已发现遗传变异和局部甲基化模式在南方推广 然后研究常见的基因变异和DNA甲基化之间的联系 冠状动脉大小的图案。 K24将确保有足够的时间在金屋博士的研究中进行下一阶段的研究，同时保护时间 致力于在面向患者的研究中指导未来的临床研究人员。发展的计划， 研究和指导旨在相辅相成，并产生协同效应 以病人为中心的研究中的指导和研究。建议的指导、研究和职业 发展活动积极利用现有的基础设施、资源和由 包括CTSI在内的美国国立卫生研究院，以及金屋博士在加州大学旧金山分校的积极研究项目。

PROJECT SUMMARY/ABSTRACT Dr. Alka Kanaya is Professor in the Departments of Medicine, Epidemiology and Biostatistics at the University of California San Francisco. Trained in Internal Medicine and Epidemiology, over the past decade she has mentored several individuals at different levels in their training and developed a thriving program of multidisciplinary collaborative research focused on cardiovascular disease epidemiology and prevention. She is currently funded by the NHLBI to conduct a prospective cohort study of South Asians called the MASALA study which is modeled on the existing Multi-Ethnic Study of Atherosclerosis (MESA) to understand the antecedents of cardiovascular disease in this high risk ethnic group. With the support of the K24 renewal, Dr. Kanaya will extend the research program by adding measures of coronary artery cross-sectional area to further knowledge on atherosclerosis markers and ASCVD. The Overall Aims of this K24 proposal are: (1) To measure coronary artery size (cross-sectional area and diameter) among 500 South Asians (age 45-65 years) in the MASALA study and describe coronary artery size by age, sex, and CAC category. (2) To compare coronary size of similar aged South Asians in MASALA with Whites and African Americans in CARDIA after adjusting for age, sex, body mass index and cardiovascular risk factors. (3) To determine the association between coronary artery size in South Asians with known cardiovascular risk factors, ectopic fat distribution, and biomarkers. (4) To determine whether previously discovered genetic variants and local methylation patterns for cardiometabolic traits generalize to South Asians, and then to investigate the association between common genetic variants and DNA methylation patterns with coronary artery size. The K24 would insure sufficient time to pursue this next phase in Dr. Kanaya's research while protecting time to devote to mentoring future clinical investigators in patient-oriented research. The plans for development, research, and mentoring were designed to complement each other and to create a synergistic effect of mentoring and research in patient-oriented research. The proposed mentoring, research, and career development activities actively leverage existing infrastructure, resources, and training initiatives provided by NIH including the CTSI, and Dr. Kanaya's active research program at UCSF.