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Coronary artery cross-sectional area and cardiovascular risk in South Asians

Coronary artery cross-sectional area and cardiovascular risk in South Asians
南亚人的冠状动脉横截面积和心血管风险
批准号:
10404115
负责人:
ALKA M. KANAYA
金额:
$12.09万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-08-01 至 2024-05-31
关键词:
AbdomenAfrican American populationAgeAmericasAngiographyAreaAsian populationAtherosclerosisBangladeshBiologicalBiological MarkersBiometryBlack AmericanBlack PopulationsBlood VesselsBody SizeBody fatBody mass indexCaliberCaliforniaCardiacCardiovascular DiseasesCardiovascular systemCategoriesClinical InvestigatorComplementCoronaryCoronary Artery Risk Development in Young Adults StudyCoronary StenosisCoronary arteryDNA MethylationDataDevelopment PlansDiabetes MellitusDyslipidemiasEnrollmentEpidemiologyEpigenetic ProcessEthnic groupEtiologyEventFatty acid glycerol estersFundingFutureGeneticGenetic RiskGeographic LocationsGoalsGrantHepaticHigh PrevalenceHypertensionIndiaIndividualInfrastructureInternal MedicineKnowledgeLinkLipoprotein (a)LiverLongitudinal StudiesMeasuresMediator of activation proteinMedicineMentorsMinority GroupsModelingMulti-Ethnic Study of AtherosclerosisNational Heart, Lung, and Blood InstituteNepalNon-Insulin-Dependent Diabetes MellitusObesityPakistanParticipantPathogenicityPatternPericardial body locationPhasePhenotypePrevalencePreventionProspective cohort studyRaceResearchResourcesRisk FactorsSan FranciscoSliceSmokingSouth AsianSri LankaTNF geneThinnessTimeTrainingUnited States National Institutes of HealthUniversitiesUrsidae FamilyVisceralVisceral fatWomanX-Ray Computed Tomographyadiponectinagedatherosclerosis riskattenuationcardiometabolic riskcardiometabolismcardiovascular disorder epidemiologycardiovascular disorder riskcardiovascular risk factorcareer developmentcaucasian Americanclinical riskcohortcoronary artery calciumcoronary calcium scoringcoronary plaquedesignethnic disparityethnic minority populationfollow-upgenetic variantheart imaginghigh riskhigh risk populationmalemenmethylation biomarkermethylation patternmultidisciplinarynovelpatient oriented researchprofessorprognostic significanceprogramsprospectiveresearch and developmentresistinresponsesexsocial culturetrait

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英文摘要
PROJECT SUMMARY/ABSTRACT Dr. Alka Kanaya is Professor in the Departments of Medicine, Epidemiology and Biostatistics at the University of California San Francisco. Trained in Internal Medicine and Epidemiology, over the past decade she has mentored several individuals at different levels in their training and developed a thriving program of multidisciplinary collaborative research focused on cardiovascular disease epidemiology and prevention. She is currently funded by the NHLBI to conduct a prospective cohort study of South Asians called the MASALA study which is modeled on the existing Multi-Ethnic Study of Atherosclerosis (MESA) to understand the antecedents of cardiovascular disease in this high risk ethnic group. With the support of the K24 renewal, Dr. Kanaya will extend the research program by adding measures of coronary artery cross-sectional area to further knowledge on atherosclerosis markers and ASCVD. The Overall Aims of this K24 proposal are: (1) To measure coronary artery size (cross-sectional area and diameter) among 500 South Asians (age 45-65 years) in the MASALA study and describe coronary artery size by age, sex, and CAC category. (2) To compare coronary size of similar aged South Asians in MASALA with Whites and African Americans in CARDIA after adjusting for age, sex, body mass index and cardiovascular risk factors. (3) To determine the association between coronary artery size in South Asians with known cardiovascular risk factors, ectopic fat distribution, and biomarkers. (4) To determine whether previously discovered genetic variants and local methylation patterns for cardiometabolic traits generalize to South Asians, and then to investigate the association between common genetic variants and DNA methylation patterns with coronary artery size. The K24 would insure sufficient time to pursue this next phase in Dr. Kanaya's research while protecting time to devote to mentoring future clinical investigators in patient-oriented research. The plans for development, research, and mentoring were designed to complement each other and to create a synergistic effect of mentoring and research in patient-oriented research. The proposed mentoring, research, and career development activities actively leverage existing infrastructure, resources, and training initiatives provided by NIH including the CTSI, and Dr. Kanaya's active research program at UCSF.
期刊论文(4)
专著(0)
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会议论文
DOI: 10.12669/pjms.36.7.3292
发表时间: 2020-11
期刊: Pakistan journal of medical sciences
影响因子: 2.2
作者: [Saeed S, Kanaya AM, Bennet L, Nilsson PM]
通讯作者: Nilsson PM
DOI: 10.1161/jaha.122.027079
发表时间: 2023-02-07
期刊: JOURNAL OF THE AMERICAN HEART ASSOCIATION
影响因子: 5.4
作者: [Chen, Debbie C., Lees, Jennifer S., Lu, Kaiwei, Scherzer, Rebecca, Rutherford, Elaine, Mark, Patrick B., Kanaya, Alka M., Shlipak, Michael G., Estrella, Michelle M.]
通讯作者: Estrella, Michelle M.
Metabolic effects and mechanisms for heart failure in South Asians
Metabolic effects and mechanisms for heart failure in South Asians
Metabolic effects and mechanisms for heart failure in South Asians
Institutional Career Development Core
海外基金