Core A: Human Metabolism

核心A：人体新陈代谢

• 批准号: 10457900
• 负责人: ALKA M. KANAYA
• 金额: $ 19.02万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10457900
• 关键词: Anatomy; Anthropometry; Area; Behavior assessment; Biological Assay; Biological Markers; Biometry; Body Composition; Body fat; Bone Density; Clinical; Clinical Research; Communities; Complex; Consultations; Core Facility; Development; Disease; Exercise; Fatty acid glycerol esters; Feedback; First Independent Research Support and Transition Awards; Future; Genetic; Goals; Grant; Growth; Health; Health Services Research; Hormones; Human; Human Microbiome; Inflammatory; Infrastructure; Inpatients; Laboratories; Lead; Lipids; Manuscripts; Measurement; Measures; Metabolic; Metabolic Diseases; Metabolism; Methods; Mus; Nursing Staff; Nutrition Assessment; Obesity; Outpatients; Output; Participant; Patient Recruitments; Performance; Physical activity; Procedures; Radiology Specialty; Research; Research Design; Research Personnel; Research Technics; Running; Services; Ships; Testing; Tissues; Training; Translational Research; Venous blood sampling; Water; adipokines; behavior measurement; biobehavioral measurement; data management; human subject; imaging facilities; improved; innovation; instrument; instrumentation; interest; lean body mass; meetings; member; new technology; novel; nutrition; programs; radiological imaging; recruit; research facility; research study; response; tool; translational study

Biomedical Core A (Human Metabolism): Summary The UCSF-NORC has facilitated clinical and translational studies in humans. During the first award period, members of the UCSF-NORC had greater access to clinical research facilities and services that are housed in different research units and departments, and the NORC administrative infrastructure was able to efficiently coordinate their activities to serve NORC research needs. The NORC Human Metabolism Core will continue to provide that coordinating function to integrate Core activities with NORC research, and will facilitate greater access to a metabolic laboratory assay unit in this new grant period. The current and newly proposed NORC Human Metabolism Core services include: 1) Body composition, exercise, and metabolism testing to measure metabolic output and functional performance, as well as total and regional fat content, lean body mass and bone density. 2) One of the world's most advanced radiologic imaging facilities that will visualize and quantitatively measure anatomical structures and their intra-tissue lipid and water content. 3) Consultation services to provide assistance with nutrition and biobehavioral measurements, research study design, participant recruitment, biostatistical analysis, data management, and grant/manuscript editing. 4) Clinical research services to assist with participant measurements, metabolic procedures, phlebotomy, and biospecimen processing and shipments. 5) In the current application, we propose to expand our Core services to include a new metabolic laboratory assay service which will run hormone, adipokine and inflammatory panel assays for NORC-related studies. Currently, 23 of the total 58 UCSF-NORC investigators use or plan to use the Human Metabolism Core services to conduct obesity-related studies and measure metabolism, physical activity, nutrition, body fat content and distribution, and a range of obesity related laboratory biomarkers With the breadth of research programs at UCSF, continued NORC support for a dedicated NORC Human Metabolism Core will enable exciting research programs to pursue novel, previously unexplored directions in obesity, nutrition and/or metabolism research.

生物医学核心 A（人体新陈代谢）：总结 UCSF-NORC 促进了人类的临床和转化研究。在第一个奖励期间， UCSF-NORC 的成员可以更方便地使用位于 不同的研究单位和部门，以及 NORC 的行政基础设施能够有效地 协调他们的活动以满足 NORC 研究需求。 NORC 人类代谢核心将继续 提供将核心活动与 NORC 研究相结合的协调职能，并将促进更大的 在这个新的资助期内使用代谢实验室测定装置。当前和新提议的 NORC 人体新陈代谢核心服务包括： 1) 身体成分、运动和代谢测试，以测量代谢输出和功能 表现，以及总脂肪含量和局部脂肪含量、去脂体重和骨密度。 2) 世界上最先进的放射成像设施之一，可实现可视化和定量化 测量解剖结构及其组织内脂质和水含量。 3) 提供营养和生物行为测量、研究协助的咨询服务 研究设计、参与者招募、生物统计分析、数据管理和资助/手稿编辑。 4) 临床研究服务，协助参与者测量、代谢程序、静脉切开术、 以及生物样本处理和运输。 5) 在当前的应用程序中，我们建议扩展我们的核心服务，以包括新的代谢 实验室检测服务，将对 NORC 相关的激素、脂肪因子和炎症组进行检测 研究。 目前，总共 58 名 UCSF-NORC 研究人员中有 23 名正在使用或计划使用人类代谢核心 进行肥胖相关研究并测量新陈代谢、体力活动、营养、体脂的服务 含量和分布，以及一系列与肥胖相关的实验室生物标志物 随着研究的广度 在 UCSF 的项目中，NORC 对专用 NORC 人类代谢核心的持续支持将使 令人兴奋的研究项目，以追求肥胖、营养和/或方面新颖的、以前未探索的方向 代谢研究。