Ectopic fat and atherosclerosis in South Asians

南亚人的异位脂肪和动脉粥样硬化

• 批准号: 8441395
• 负责人: ALKA M. KANAYA
• 金额: $ 11.65万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8441395
• 关键词: Abdomen; Accounting; Adipose tissue; Age; Age Distribution; Asian Indian; Atherosclerosis; Award; Biometry; Body Composition; Body Size; Body fat; Body mass index; Calcium; California; Cardiac; Cardiovascular Diseases; Cardiovascular system; Carotid Atherosclerotic Disease; Categories; Clinical Investigator; Clinical Sciences; Cohort Studies; Complement; Coronary artery; Data; Diabetes Mellitus; Disease; Disease Outcome; Epidemiology; Ethnic group; Event; Fatty acid glycerol esters; Funding; Future; Goals; Grant; Heart Diseases; Hepatic; Heterogeneity; High Prevalence; Hormones; Individual; Inflammatory; Institutes; Interleukin-6; Internal Medicine; Intervention; Leptin; Link; Location; Longitudinal Studies; Measurement; Measures; Medicine; Mentors; Metabolic; Metabolic Diseases; Methods; Minority Groups; Modeling; National Heart, Lung, and Blood Institute; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Pericardial body location; Pilot Projects; Population; Prevalence; Prevention; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; San Francisco; South Asian; Staging; Techniques; Testing; Thick; Time; Training; Translational Research; Tumor Necrosis Factor-alpha; United States; United States National Institutes of Health; Universities; Ursidae Family; Visceral; adipokines; adiponectin; cardiovascular risk factor; career; career development; cohort; cost effective; design; disorder risk; ethnic minority population; glucose tolerance; high risk; intima media; multidisciplinary; novel; patient oriented; patient oriented research; professor; programs; prospective; research and development; resistin; sex; sobriety; socioeconomics; subcutaneous; waist circumference

DESCRIPTION (provided by applicant): Dr. Alka Kanaya is an Associate Professor in the Departments of Medicine, Epidemiology and Biostatistics at the University of California San Francisco. Trained in Internal Medicine and Epidemiology, over the past decade she has mentored several individuals at different levels in their training and developed a thriving program of multidisciplinary collaborative research focused on diabetes and cardiovascular disease epidemiology and prevention. Dr. Kanaya is at an ideal stage of her career for a K24 grant. Support from this award would allow her to leverage her research program to develop the careers of new patient-oriented researchers. She is currently funded by the NHLBI to conduct a prospective cohort study of South Asians called the MASALA study which is modeled on the existing Multi-Ethnic Study of Atherosclerosis (MESA) to understand the antecedents of diabetes and cardiovascular disease in this high risk ethnic group. With the support of the K24, Dr. Kanaya will extend the research program by adding measurements of ectopic fat and adipokines to the MASALA study cohort and make comparisons to four other U.S. ethnic groups in MESA. The Overall Aims of this K24 proposal are: (1) To measure ectopic fat depots and adipokines among 900 South Asians in the MASALA study and to describe and compare ectopic fat depots and adipokines between the South Asians and the four MESA ethnic groups after adjusting for age and overall body size. (2) To test the hypothesis that higher ectopic fat will be associated with worsened glucose tolerance; that adipokines will explain the association between the ectopic fat depots and glucose tolerance status; and that the increased prevalence of diabetes among the South Asians compared to the MESA ethnic groups will be explained by the ectopic fat depot and adipokines. (3) To test the hypothesis that higher amounts of ectopic fat will be associated with greater subclinical atherosclerosis; that adipokines will explain the association between the ectopic fat depots and subclinical atherosclerosis; and that the difference in subclinical atherosclerosis prevalence among the South Asians compared to the MESA ethnic groups can be explained by the ectopic fat depot and adipokines. (4) To determine whether baseline levels of ectopic fat are independently associated with incident cardiovascular events among South Asians after adjusting for traditional cardiovascular risk factors; and whether differences in CVD outcomes between South Asians and the MESA ethnic groups can be explained by the ectopic fat depot and adipokine levels. The K24 would insure sufficient time to pursue this natural progression of Dr. Kanaya's research while protecting time to devote to mentoring future clinical investigators in patient-oriented research. The plans for development, research, and mentoring were designed to complement each other and to create a synergistic effect of mentoring and research in patient-oriented research. The proposed mentoring, research, and career development activities actively leverage existing infrastructure, resources, and training initiatives provided by NIH, including Dr. Kanaya's active research program and the Clinical and Translational Science Institute (CTSI) at UCSF.

描述(由申请人提供)：Alka Kanaya博士是加州大学旧金山分校医学、流行病学和生物统计学系的副教授。在过去的十年里，她接受了内科和流行病学的培训，在不同级别的培训中指导了几个人，并制定了一个蓬勃发展的计划 多学科合作研究的重点是糖尿病和心血管疾病流行病学和预防。Kanaya博士正处于她职业生涯的理想阶段，可以获得K24拨款。这一奖项的支持将使她能够利用她的研究计划来发展新的以患者为导向的研究人员的职业生涯。她目前由NHLBI资助，对南亚人进行一项名为Masala研究的前瞻性队列研究，该研究仿照现有的动脉粥样硬化多种族研究(MESA)，以了解这一高危民族中糖尿病和心血管疾病的前驱因素。在K24的支持下，Kanaya博士将扩大研究计划，将异位脂肪和脂肪因子的测量添加到Masala研究队列中，并与梅萨的其他四个美国种族进行比较。这项K24建议的总体目标是：(1)在Masala研究中测量900名南亚人的异位脂肪库和脂肪因子，并描述和比较南亚人和四个台地民族之间的异位脂肪库和脂肪因子，在调整了年龄和整体身体尺寸后。(2)检验假设，即较高的异位脂肪将与恶化的葡萄糖耐量相关；脂肪因子将解释异位脂肪储存与葡萄糖耐量状态之间的关联；以及南亚人与台地民族相比糖尿病患病率的增加将由异位脂肪储存和脂肪因子解释。(3)检验以下假设：异位脂肪量较高将与更大的亚临床动脉粥样硬化相关；脂肪因子将解释异位脂肪库与亚临床动脉粥样硬化之间的关联；以及南亚人与台地民族之间亚临床动脉粥样硬化患病率的差异可以由异位脂肪库和脂肪因子来解释。(4)确定在调整了传统心血管危险因素后，基线异位脂肪水平是否与南亚人发生的心血管事件独立相关；以及是否可以用异位脂肪库和脂肪因子水平来解释南亚人和梅萨民族之间心血管疾病结局的差异。K24将确保有足够的时间来追求金屋博士研究的这一自然进展，同时保护时间，以便在以患者为导向的研究中致力于指导未来的临床研究人员。开发、研究和指导计划旨在相辅相成，并在以患者为导向的研究中创造指导和研究的协同效应。拟议的指导、研究和职业发展活动积极利用NIH提供的现有基础设施、资源和培训计划，包括Kanaya博士的积极研究计划和加州大学旧金山分校的临床和翻译科学研究所(CTSI)。