Ectopic fat and atherosclerosis in South Asians
南亚人的异位脂肪和动脉粥样硬化
基本信息
- 批准号:8441395
- 负责人:
- 金额:$ 11.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-08-01 至 2018-05-31
- 项目状态:已结题
- 来源:
- 关键词:AbdomenAccountingAdipose tissueAgeAge DistributionAsian IndianAtherosclerosisAwardBiometryBody CompositionBody SizeBody fatBody mass indexCalciumCaliforniaCardiacCardiovascular DiseasesCardiovascular systemCarotid Atherosclerotic DiseaseCategoriesClinical InvestigatorClinical SciencesCohort StudiesComplementCoronary arteryDataDiabetes MellitusDiseaseDisease OutcomeEpidemiologyEthnic groupEventFatty acid glycerol estersFundingFutureGoalsGrantHeart DiseasesHepaticHeterogeneityHigh PrevalenceHormonesIndividualInflammatoryInstitutesInterleukin-6Internal MedicineInterventionLeptinLinkLocationLongitudinal StudiesMeasurementMeasuresMedicineMentorsMetabolicMetabolic DiseasesMethodsMinority GroupsModelingNational Heart, Lung, and Blood InstituteNon-Insulin-Dependent Diabetes MellitusObesityOutcomeOverweightPericardial body locationPilot ProjectsPopulationPrevalencePreventionResearchResearch InfrastructureResearch PersonnelResourcesRiskRisk FactorsSan FranciscoSouth AsianStagingTechniquesTestingThickTimeTrainingTranslational ResearchTumor Necrosis Factor-alphaUnited StatesUnited States National Institutes of HealthUniversitiesUrsidae FamilyVisceraladipokinesadiponectincardiovascular risk factorcareercareer developmentcohortcost effectivedesigndisorder riskethnic minority populationglucose tolerancehigh riskintima mediamultidisciplinarynovelpatient orientedpatient oriented researchprofessorprogramsprospectiveresearch and developmentresistinsexsobrietysocioeconomicssubcutaneouswaist circumference
项目摘要
DESCRIPTION (provided by applicant): Dr. Alka Kanaya is an Associate Professor in the Departments of Medicine, Epidemiology and Biostatistics at the University of California San Francisco. Trained in Internal Medicine and Epidemiology, over the past decade she has mentored several individuals at different levels in their training and developed a thriving program
of multidisciplinary collaborative research focused on diabetes and cardiovascular disease epidemiology and prevention. Dr. Kanaya is at an ideal stage of her career for a K24 grant. Support from this award would allow her to leverage her research program to develop the careers of new patient-oriented researchers. She is currently funded by the NHLBI to conduct a prospective cohort study of South Asians called the MASALA study which is modeled on the existing Multi-Ethnic Study of Atherosclerosis (MESA) to understand the antecedents of diabetes and cardiovascular disease in this high risk ethnic group. With the support of the K24, Dr. Kanaya will extend the research program by adding measurements of ectopic fat and adipokines to the MASALA study cohort and make comparisons to four other U.S. ethnic groups in MESA. The Overall Aims of this K24 proposal are: (1) To measure ectopic fat depots and adipokines among 900 South Asians in the MASALA study and to describe and compare ectopic fat depots and adipokines between the South Asians and the four MESA ethnic groups after adjusting for age and overall body size. (2) To test the hypothesis that higher ectopic fat will be associated with worsened glucose tolerance; that adipokines will explain the association between the ectopic fat depots and glucose tolerance status; and that the increased prevalence of diabetes among the South Asians compared to the MESA ethnic groups will be explained by the ectopic fat depot and adipokines. (3) To test the hypothesis that higher amounts of ectopic fat will be associated with greater subclinical atherosclerosis; that adipokines will explain the association between the ectopic fat depots and subclinical atherosclerosis; and that the difference in subclinical atherosclerosis prevalence among the South Asians compared to the MESA ethnic groups can be explained by the ectopic fat depot and adipokines. (4) To determine whether baseline levels of ectopic fat are independently associated with incident cardiovascular events among South Asians after adjusting for traditional cardiovascular risk factors; and whether differences in CVD outcomes between South Asians and the MESA ethnic groups can be explained by the ectopic fat depot and adipokine levels. The K24 would insure sufficient time to pursue this natural progression of Dr. Kanaya's research while protecting time to devote to mentoring future clinical investigators in patient-oriented research. The plans for development, research, and mentoring were designed to complement each other and to create a synergistic effect of mentoring and research in patient-oriented research. The proposed mentoring, research, and career development activities actively leverage existing infrastructure, resources, and training initiatives provided by NIH, including Dr. Kanaya's active research program and the Clinical and Translational Science Institute (CTSI) at UCSF.
描述(由申请人提供):Alka Kanaya博士是加州大学旧金山分校医学、流行病学和生物统计学系的副教授。在过去的十年里,她接受了内科和流行病学的培训,在不同级别的培训中指导了几个人,并制定了一个蓬勃发展的计划
多学科合作研究的重点是糖尿病和心血管疾病流行病学和预防。Kanaya博士正处于她职业生涯的理想阶段,可以获得K24拨款。这一奖项的支持将使她能够利用她的研究计划来发展新的以患者为导向的研究人员的职业生涯。她目前由NHLBI资助,对南亚人进行一项名为Masala研究的前瞻性队列研究,该研究仿照现有的动脉粥样硬化多种族研究(MESA),以了解这一高危民族中糖尿病和心血管疾病的前驱因素。在K24的支持下,Kanaya博士将扩大研究计划,将异位脂肪和脂肪因子的测量添加到Masala研究队列中,并与梅萨的其他四个美国种族进行比较。这项K24建议的总体目标是:(1)在Masala研究中测量900名南亚人的异位脂肪库和脂肪因子,并描述和比较南亚人和四个台地民族之间的异位脂肪库和脂肪因子,在调整了年龄和整体身体尺寸后。(2)检验假设,即较高的异位脂肪将与恶化的葡萄糖耐量相关;脂肪因子将解释异位脂肪储存与葡萄糖耐量状态之间的关联;以及南亚人与台地民族相比糖尿病患病率的增加将由异位脂肪储存和脂肪因子解释。(3)检验以下假设:异位脂肪量较高将与更大的亚临床动脉粥样硬化相关;脂肪因子将解释异位脂肪库与亚临床动脉粥样硬化之间的关联;以及南亚人与台地民族之间亚临床动脉粥样硬化患病率的差异可以由异位脂肪库和脂肪因子来解释。(4)确定在调整了传统心血管危险因素后,基线异位脂肪水平是否与南亚人发生的心血管事件独立相关;以及是否可以用异位脂肪库和脂肪因子水平来解释南亚人和梅萨民族之间心血管疾病结局的差异。K24将确保有足够的时间来追求金屋博士研究的这一自然进展,同时保护时间,以便在以患者为导向的研究中致力于指导未来的临床研究人员。开发、研究和指导计划旨在相辅相成,并在以患者为导向的研究中创造指导和研究的协同效应。拟议的指导、研究和职业发展活动积极利用NIH提供的现有基础设施、资源和培训计划,包括Kanaya博士的积极研究计划和加州大学旧金山分校的临床和翻译科学研究所(CTSI)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ALKA M. KANAYA其他文献
ALKA M. KANAYA的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ALKA M. KANAYA', 18)}}的其他基金
Metabolic effects and mechanisms for heart failure in South Asians
南亚人心力衰竭的代谢效应和机制
- 批准号:
10642776 - 财政年份:2021
- 资助金额:
$ 11.65万 - 项目类别:
Metabolic effects and mechanisms for heart failure in South Asians
南亚人心力衰竭的代谢效应和机制
- 批准号:
10421268 - 财政年份:2021
- 资助金额:
$ 11.65万 - 项目类别:
Metabolic effects and mechanisms for heart failure in South Asians
南亚人心力衰竭的代谢效应和机制
- 批准号:
10049526 - 财政年份:2021
- 资助金额:
$ 11.65万 - 项目类别:
Coronary artery cross-sectional area and cardiovascular risk in South Asians
南亚人的冠状动脉横截面积和心血管风险
- 批准号:
10176172 - 财政年份:2013
- 资助金额:
$ 11.65万 - 项目类别:
Coronary artery cross-sectional area and cardiovascular risk in South Asians
南亚人的冠状动脉横截面积和心血管风险
- 批准号:
10404115 - 财政年份:2013
- 资助金额:
$ 11.65万 - 项目类别:
Ectopic fat and atherosclerosis in South Asians
南亚人的异位脂肪和动脉粥样硬化
- 批准号:
8706951 - 财政年份:2013
- 资助金额:
$ 11.65万 - 项目类别:
Ectopic fat and atherosclerosis in South Asians
南亚人的异位脂肪和动脉粥样硬化
- 批准号:
9262958 - 财政年份:2013
- 资助金额:
$ 11.65万 - 项目类别:
相似海外基金
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 11.65万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
- 批准号:
10100360 - 财政年份:2024
- 资助金额:
$ 11.65万 - 项目类别:
Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
- 批准号:
24K04974 - 财政年份:2024
- 资助金额:
$ 11.65万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
- 批准号:
2312319 - 财政年份:2023
- 资助金额:
$ 11.65万 - 项目类别:
Standard Grant
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
- 批准号:
23K01686 - 财政年份:2023
- 资助金额:
$ 11.65万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
- 批准号:
23K01692 - 财政年份:2023
- 资助金额:
$ 11.65万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
- 批准号:
23K01695 - 财政年份:2023
- 资助金额:
$ 11.65万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
- 批准号:
23K01713 - 财政年份:2023
- 资助金额:
$ 11.65万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
- 批准号:
23K01715 - 财政年份:2023
- 资助金额:
$ 11.65万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
- 批准号:
10585388 - 财政年份:2023
- 资助金额:
$ 11.65万 - 项目类别: