Ectopic fat and atherosclerosis in South Asians

南亚人的异位脂肪和动脉粥样硬化

• 批准号: 8441395
• 负责人: ALKA M. KANAYA
• 金额: $ 11.65万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8441395
• 关键词: Abdomen; Accounting; Adipose tissue; Age; Age Distribution; Asian Indian; Atherosclerosis; Award; Biometry; Body Composition; Body Size; Body fat; Body mass index; Calcium; California; Cardiac; Cardiovascular Diseases; Cardiovascular system; Carotid Atherosclerotic Disease; Categories; Clinical Investigator; Clinical Sciences; Cohort Studies; Complement; Coronary artery; Data; Diabetes Mellitus; Disease; Disease Outcome; Epidemiology; Ethnic group; Event; Fatty acid glycerol esters; Funding; Future; Goals; Grant; Heart Diseases; Hepatic; Heterogeneity; High Prevalence; Hormones; Individual; Inflammatory; Institutes; Interleukin-6; Internal Medicine; Intervention; Leptin; Link; Location; Longitudinal Studies; Measurement; Measures; Medicine; Mentors; Metabolic; Metabolic Diseases; Methods; Minority Groups; Modeling; National Heart, Lung, and Blood Institute; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Pericardial body location; Pilot Projects; Population; Prevalence; Prevention; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; San Francisco; South Asian; Staging; Techniques; Testing; Thick; Time; Training; Translational Research; Tumor Necrosis Factor-alpha; United States; United States National Institutes of Health; Universities; Ursidae Family; Visceral; adipokines; adiponectin; cardiovascular risk factor; career; career development; cohort; cost effective; design; disorder risk; ethnic minority population; glucose tolerance; high risk; intima media; multidisciplinary; novel; patient oriented; patient oriented research; professor; programs; prospective; research and development; resistin; sex; sobriety; socioeconomics; subcutaneous; waist circumference

DESCRIPTION (provided by applicant): Dr. Alka Kanaya is an Associate Professor in the Departments of Medicine, Epidemiology and Biostatistics at the University of California San Francisco. Trained in Internal Medicine and Epidemiology, over the past decade she has mentored several individuals at different levels in their training and developed a thriving program of multidisciplinary collaborative research focused on diabetes and cardiovascular disease epidemiology and prevention. Dr. Kanaya is at an ideal stage of her career for a K24 grant. Support from this award would allow her to leverage her research program to develop the careers of new patient-oriented researchers. She is currently funded by the NHLBI to conduct a prospective cohort study of South Asians called the MASALA study which is modeled on the existing Multi-Ethnic Study of Atherosclerosis (MESA) to understand the antecedents of diabetes and cardiovascular disease in this high risk ethnic group. With the support of the K24, Dr. Kanaya will extend the research program by adding measurements of ectopic fat and adipokines to the MASALA study cohort and make comparisons to four other U.S. ethnic groups in MESA. The Overall Aims of this K24 proposal are: (1) To measure ectopic fat depots and adipokines among 900 South Asians in the MASALA study and to describe and compare ectopic fat depots and adipokines between the South Asians and the four MESA ethnic groups after adjusting for age and overall body size. (2) To test the hypothesis that higher ectopic fat will be associated with worsened glucose tolerance; that adipokines will explain the association between the ectopic fat depots and glucose tolerance status; and that the increased prevalence of diabetes among the South Asians compared to the MESA ethnic groups will be explained by the ectopic fat depot and adipokines. (3) To test the hypothesis that higher amounts of ectopic fat will be associated with greater subclinical atherosclerosis; that adipokines will explain the association between the ectopic fat depots and subclinical atherosclerosis; and that the difference in subclinical atherosclerosis prevalence among the South Asians compared to the MESA ethnic groups can be explained by the ectopic fat depot and adipokines. (4) To determine whether baseline levels of ectopic fat are independently associated with incident cardiovascular events among South Asians after adjusting for traditional cardiovascular risk factors; and whether differences in CVD outcomes between South Asians and the MESA ethnic groups can be explained by the ectopic fat depot and adipokine levels. The K24 would insure sufficient time to pursue this natural progression of Dr. Kanaya's research while protecting time to devote to mentoring future clinical investigators in patient-oriented research. The plans for development, research, and mentoring were designed to complement each other and to create a synergistic effect of mentoring and research in patient-oriented research. The proposed mentoring, research, and career development activities actively leverage existing infrastructure, resources, and training initiatives provided by NIH, including Dr. Kanaya's active research program and the Clinical and Translational Science Institute (CTSI) at UCSF.

描述（由申请人提供）：Alka Kanaya 博士是加州大学旧金山分校医学、流行病学和生物统计学系的副教授。她接受过内科和流行病学培训，在过去的十年里，她在不同级别的培训中指导了几位个人，并制定了蓬勃发展的计划 专注于糖尿病和心血管疾病流行病学和预防的多学科合作研究。 Kanaya 博士正处于获得 K24 资助的职业生涯的理想阶段。该奖项的支持将使她能够利用她的研究项目来发展以患者为中心的新研究人员的职业生涯。她目前得到 NHLBI 的资助，对南亚人进行一项名为 MASALA 研究的前瞻性队列研究，该研究以现有的动脉粥样硬化多种族研究 (MESA) 为模型，旨在了解这一高风险种族群体中糖尿病和心血管疾病的发生原因。在 K24 的支持下，Kanaya 博士将通过在 MASALA 研究队列中添加异位脂肪和脂肪因子的测量来扩展研究计划，并与 MESA 的其他四个美国族群进行比较。该 K24 提案的总体目标是：（1）测量 MASALA 研究中 900 名南亚人的异位脂肪库和脂肪因子，并在调整年龄和整体体型后描述和比较南亚人和四个 MESA 族群之间的异位脂肪库和脂肪因子。 (2) 检验较高的异位脂肪与糖耐量恶化相关的假设；脂肪因子将解释异位脂肪库与葡萄糖耐量状态之间的关联；与 MESA 族群相比，南亚人糖尿病患病率增加的原因是异位脂肪库和脂肪因子。 (3) 检验较高量的异位脂肪与较严重的亚临床动脉粥样硬化相关的假设；脂肪因子将解释异位脂肪库与亚临床动脉粥样硬化之间的关联；南亚人与 MESA 族群相比，亚临床动脉粥样硬化患病率的差异可以通过异位脂肪库和脂肪因子来解释。 (4) 在调整传统心血管危险因素后，确定异位脂肪的基线水平是否与南亚人的心血管事件独立相关；南亚人和 MESA 族群之间 CVD 结果的差异是否可以通过异位脂肪库和脂肪因子水平来解释。 K24 将确保有足够的时间来追求 Kanaya 博士研究的自然进展，同时保留时间致力于指导未来的临床研究人员进行以患者为导向的研究。开发、研究和指导计划旨在相互补充，并在以患者为导向的研究中产生指导和研究的协同效应。拟议的指导、研究和职业发展活动积极利用 NIH 提供的现有基础设施、资源和培训计划，包括 Kanaya 博士的积极研究计划和 UCSF 的临床和转化科学研究所 (CTSI)。