Core A: Human Metabolism

生物医学核心A（人体代谢）：总结 UCSF-NORC促进了人类的临床和转化研究。在第一个授标期间， UCSF-NORC的成员有更多的机会获得临床研究设施和服务， 不同的研究单位和部门，以及NORC的行政基础设施能够有效地 协调他们的活动，以满足NORC的研究需求。NORC人类代谢核心将继续 提供协调功能，将核心活动与NORC研究相结合，并将促进更大的 获得代谢实验室化验单位在这个新的补助金期间。目前和新提议的NORC 人体代谢核心服务包括： 1)身体成分、运动和代谢测试，以测量代谢输出和功能 性能，以及总脂肪含量和局部脂肪含量，瘦体重和骨密度。 2)世界上最先进的放射成像设备之一，将可视化和定量 测量解剖结构及其组织内脂质和水含量。 3)提供咨询服务，协助进行营养和生物行为测量、研究 研究设计、参与者招募、生物统计分析、数据管理和资助/手稿编辑。 4)临床研究服务，以协助参与者测量，代谢程序，静脉切开术， 以及生物样本处理和运输。 5)在当前的应用中，我们建议扩展我们的核心服务，以包括新的代谢 实验室分析服务，将运行激素，脂肪因子和炎症面板分析，为NORC相关 问题研究 目前，58名UCSF-NORC研究者中有23名使用或计划使用人体代谢核心 服务进行肥胖相关的研究和测量新陈代谢，体力活动，营养，身体脂肪 含量和分布，以及一系列与肥胖相关的实验室生物标志物随着研究的广度 在UCSF的计划，继续NORC支持一个专门的NORC人类代谢核心将使 令人兴奋的研究计划，以追求新的，以前未探索的方向，肥胖，营养和/或 代谢研究

Biomedical Core A (Human Metabolism): Summary The UCSF-NORC has facilitated clinical and translational studies in humans. During the first award period, members of the UCSF-NORC had greater access to clinical research facilities and services that are housed in different research units and departments, and the NORC administrative infrastructure was able to efficiently coordinate their activities to serve NORC research needs. The NORC Human Metabolism Core will continue to provide that coordinating function to integrate Core activities with NORC research, and will facilitate greater access to a metabolic laboratory assay unit in this new grant period. The current and newly proposed NORC Human Metabolism Core services include: 1) Body composition, exercise, and metabolism testing to measure metabolic output and functional performance, as well as total and regional fat content, lean body mass and bone density. 2) One of the world's most advanced radiologic imaging facilities that will visualize and quantitatively measure anatomical structures and their intra-tissue lipid and water content. 3) Consultation services to provide assistance with nutrition and biobehavioral measurements, research study design, participant recruitment, biostatistical analysis, data management, and grant/manuscript editing. 4) Clinical research services to assist with participant measurements, metabolic procedures, phlebotomy, and biospecimen processing and shipments. 5) In the current application, we propose to expand our Core services to include a new metabolic laboratory assay service which will run hormone, adipokine and inflammatory panel assays for NORC-related studies. Currently, 23 of the total 58 UCSF-NORC investigators use or plan to use the Human Metabolism Core services to conduct obesity-related studies and measure metabolism, physical activity, nutrition, body fat content and distribution, and a range of obesity related laboratory biomarkers With the breadth of research programs at UCSF, continued NORC support for a dedicated NORC Human Metabolism Core will enable exciting research programs to pursue novel, previously unexplored directions in obesity, nutrition and/or metabolism research.