Training Program in Integrative Membrane Biology

项目总结： 综合膜生物学培训计划(TPIMB)是为培养博士后学生而设计的 生物膜的生物学、生物物理学和生理学。现在已经进入第四个十年，TPIMB继续 在大学领导分子、细胞和系统生物学领域的跨学科培训 马里兰医学院(UMSOM)，通过关注细胞膜和细胞内的作用 调节和整合细胞功能及其与环境相互作用的膜。这个 该计划的指导思想是，研究膜生物物理和生理学，以及基于膜的 信号级联，可以提供对细胞和组织生物学的独特见解，无论是健康的还是疾病的 各州。TPIMB的教职员工有39人，他们资金充足，互动性强，并致力于 指导学生学习与膜生物学相关的广泛科目。导师的选择是为了 他们的兴趣、外部支持和对指导的承诺。受训者是根据他们的兴趣来选择的， 研究生课程成绩、推荐和以前的研究经验。需求是一门核心课程 关于生物医学科学的机制，以及为期一年的研究伦理课程，这两门课都是 这是密歇根大学所有以实验室研究为基础的研究生教育的共同特点。受训人员还必须参加 膜生物化学、生物物理学、膜之间的联系等一系列专门的高级课程 缺陷与人类疾病、生物统计学、假设检验和实验设计。他们可能还会带走 细胞和系统生理学、药理学或神经科学的选修课。学员定期参加 以学生为导向的活动，如学生研讨会系列、每月聚会和年度静修。这个 UMSOM慷慨地支持这一计划，为教师工资、额外津贴 学生，以及为TPIMB的常规活动提供资金。目前NIH/NIGMS的资金支持7名学员，但这 让许多学生在没有直接支持的情况下跟随我们的课程并参加我们的活动。我们很享受 与包括医学科学家在内的UMSOM其他NIGMS支持的项目建立强有力的合作伙伴关系 培训计划和迈耶霍夫研究生计划，这是一个国家认可的计划，支持 在科学界代表不足的少数群体。我们在研究生培养方面所做的努力，取得了成功 招聘，以及UMSOM稳定的联邦资金表明，我们项目的持续资金是好的 这是正当的。在持续的支持下，TPIMB的教师和学生可以继续带头努力 在UMSOM整合膜、细胞和系统生物学方面的培训。

Project Summary: The Training Program in Integrative Membrane Biology (TPIMB) is designed to train pre-doctoral students in the biology, biophysics, and physiology of biological membranes. Now in its 4th decade, the TPIMB continues to lead the effort in interdisciplinary training at the interface of molecular, cell, and systems biology at the University of Maryland School of Medicine (UMSOM), by focusing on the role of the cell membrane and intracellular membranes in mediating and integrating the functions of cells and their interactions with the environment. The program is guided by the idea that studies of membrane biophysics and physiology, and of membrane-based signaling cascades, can provide unique insights into the biology of cells and tissues, in both healthy and diseased states. The faculty of the TPIMB, numbering 39 individuals, are well-funded, highly interactive, and devoted to mentoring students studying a broad range of subjects related to membrane biology. Mentors are selected for their interests, extramural support, and commitment to mentoring. Trainees are selected based on their interests, graduate course grades, recommendations, and previous research experience. Requirements are a core course on Mechanisms in Biomedical Sciences, as well as a year-long class in research ethics, both of which are common to all laboratory research-based graduate education at the UMSOM. Trainees are also required to take a series of specialized upper level courses in membrane biochemistry, biophysics, links between membrane defects and human diseases, biostatistics, hypothesis testing and experimental design. They may also take electives in cellular and systems physiology, pharmacology, or neuroscience. Trainees participate regularly in student-oriented activities, such as a student seminar series, monthly get-togethers, and an annual retreat. The UMSOM supports this program generously through contributions to faculty salary, additional stipends for students, and funds for the TPIMB's regular activities. Current NIH/NIGMS funding supports 7 trainees, but this leaves many students following our curriculum and taking part in our activities without direct support. We enjoy a strong partnership with other NIGMS-supported programs at the UMSOM including the Medical Scientist Training Program and Meyerhoff Graduate Fellows Program, a nationally recognized program that supports underrepresented minorities in the sciences. The strength of our graduate training efforts, successes in recruitment, and the stable federal funding at the UMSOM suggest that continued funding for our program is well justified. With continued support, the faculty and students in the TPIMB can continue to spearhead the effort to integrate training in membrane, cell and systems biology at the UMSOM.