TRIUX neo MEG system Upgrade

TRIUX neo MEG系统升级

• 批准号: 10177174
• 负责人: SEPPO PENTTI AHLFORS
• 金额: $ 200万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2023-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177174
• 关键词: 20 year old; Basic Science; Brain; Cerebellum; Clinical; Clinical Research; Cognitive; Collaborations; Communities; Complement; Complex; Computer software; Data; Development; Devices; Electroencephalography; Epilepsy; Experimental Designs; Fostering; Funding; Grant; Helium; Life Cycle Stages; Magnetoencephalography; Manufacturer Name; Measurement; Mental disorders; Neocortex; Neurosciences; Noise; Patients; Performance; Positioning Attribute; Research; Research Personnel; Scalp structure; Services; Signal Transduction; Sleep; Source; Structure; Supination; System; Technology; Time; Translational Research; Work; analytical tool; base; bioimaging; cost; data quality; experimental study; improved; innovation; instrumentation; nervous system disorder; next generation; novel; programs; sensor; software development; tool; translational study; user-friendly

Project Summary / Abstract This application seeks support from the ORIP High-End Instrumentation (HEI) Grant program to fund a MEGIN Triux Neo MEG system to be used for basic/clinical/translational research at the Athinoula A. Martinos Center for Biomedical Imaging. This system will replace our existing, 20-year-old Vectorview system, and will provide an substantial increase of performance for the wide range of research at the Martinos Center: psychiatric and basic neuroscience studies, clinical research on neurological and psychiatric diseases, clinical studies of epilep- tic patients, and development of novel instrumentation and analytical tools. While the Magnetoencephalography (MEG) research program at the Martinos Center has been very successful, our MEG system, installed in 2001, has come to the end of its life cycle. Service is guaranteed by the manufacturer only for another year: there is a definite need to upgrade the existing system. The proposed upgrade will not merely replace our existing MEG system but will offer new features for improved performance and data quality: (i) The instrumental noise level of the new “ARMOR” sensors is lower, which will benefit studies of deep brain structures and the cerebellum as well as studies of spontaneous brain activity in general. (ii) The sensors in the new system are very stable and robust, which guarantees uniform high data quality in long recordings in, e.g., sleep studies and in complex cognitive experiments. (iii) The new system is equipped with new EEG hardware, which facilitates high-quality recording of combined MEG/EEG data. (iv) The new system can be operated in supine, upright, and reclined positions, which provides more options for experimental design and subject/patient comfort. (v) The system is equipped with a closed-circuit helium reliquefication system, which reduces downtime, saves limited helium re- sources, and reduces operational costs. In addition, MEGIN is about to introduce new acquisition software, which makes the system more user friendly and is geared towards clinical and translational studies. The system will be an up-to-date testbed and comparison platform for the unique instrumentation and software development work at the Martinos Center, including real-time processing of MEG/EEG data, creation of new tools for detecting and analyzing signals from brain structures outside the neocortex, and development of new devices and sys- tems, which will use new sensors enabling on-scalp MEG measurements to complement the proven capabilities of the robust SQUID-based technology. The results of this development work will be freely disseminated to the MEG/EEG communities at large. By serving a highly productive interdisciplinary group of PHS-funded investiga- tors, this proposed upgrade will enhance existing research programs while at the same time fostering opportu- nities for new projects and collaborations to emerge and flourish. This upgrade will thus help pave the way for other PHS-funded research centers to optimally use both present and next-generation MEG technologies, will further help demonstrate the utility and importance of the clinical use of MEG, and will provide our investigators with a technological edge required for innovative basic and translational research, as well as for clinical studies.

项目总结/摘要 该申请寻求ORIP高端仪器（HEI）资助计划的支持，以资助MEGIN Triux Neo MEG系统将用于Athinoula A的基础/临床/转化研究。马蒂诺斯中心 用于生物医学成像该系统将取代我们现有的，20岁的Vectorview系统，并将提供 在马蒂诺斯中心的广泛研究的性能大幅增加：精神病和 基础神经科学研究，神经和精神疾病的临床研究，癫痫的临床研究， 抽搐患者，以及开发新的仪器和分析工具。虽然脑磁图 (MEG)Martinos中心的研究项目非常成功，我们的MEG系统，在2001年安装， 已经走到了生命周期的尽头制造商只保证一年的服务： 需要对现有系统进行升级。建议的提升工程不单会取代我们现有的MEG 系统，但将提供新的功能，提高性能和数据质量：（一）仪器的噪音水平， 新的“ARMOR”传感器更低，这将有利于研究大脑深部结构和小脑， 以及对大脑自发活动的研究。(ii)新系统中的传感器非常稳定， 鲁棒性，这保证了在长时间记录中的均匀高数据质量，例如，睡眠研究和复杂 认知实验(iii)新系统配备了新的EEG硬件，有助于高质量 记录组合的MEG/EEG数据。(iv)新系统可以在仰卧、直立和斜躺下操作 这为实验设计和受试者/患者舒适度提供了更多选择。(v)该系统 配备闭路氦气再循环系统，减少停机时间，节省有限的氦气再循环， 资源，降低运营成本。此外，MEGIN即将推出新的采集软件， 使该系统更加用户友好，并面向临床和转化研究。系统将 成为独特仪器和软件开发的最新测试平台和比较平台 在Martinos中心工作，包括MEG/EEG数据的实时处理， 分析来自新皮层以外的大脑结构的信号，开发新的设备和系统， tems，它将使用新的传感器，使头皮MEG测量，以补充成熟的能力 强大的基于SQUID的技术。这项开发工作的成果将免费分发给 MEG/EEG社区。通过为一个高效的跨学科小组提供服务， 这项升级计划将加强现有的研究计划，同时促进机会， 新项目和合作的出现和蓬勃发展。因此，此次升级将有助于为 其他公共卫生系统资助的研究中心，以最佳地利用目前和下一代MEG技术，将 进一步帮助证明MEG临床应用的实用性和重要性，并将为我们的研究人员提供 具有创新基础和转化研究以及临床研究所需的技术优势。