Develpment Core

项目摘要 杜克环境分析实验室(Deal)中心的目的是提供一套全面的 提供分析服务，以支持流行病学家和卫生研究人员进行侧重于 环境暴露对人类健康的影响。为此，交易开发核心将解决 开发和标准化评估的分析和数据处理方法方面的挑战 在相关媒体中暴露与健康有关的化学品。发展核心将由李博士领导 弗格森和戈登·盖辛格，他们都在环境分析化学方面拥有丰富的经验 有机和无机污染物，先进的高分辨率质谱学技术，以及 化学信息学。发展核心由三个具体目标组成，以实现这一总体目标：1) 开发测量感兴趣的新兴环境化学品的新方法，以创建一个客户- 用于在各种环境中执行环境化学品测量的响应框架 媒体；2)开发评估个人暴露的新工具，并促进整体化学暴露 评估；以及3)开发识别新的环境污染物的创新方法。 通过实现这些目标，发展核心将接受交易中心作为 整体，与环境样本分析资源(ESAR)团队紧密合作，以加强其 服务并部署新开发和验证的方法，目的是简化、协调和 大幅提升Deal和更广泛的HHEAR网络提供的服务。

PROJECT ABSTRACT The purpose of the Duke Environmental Analysis Laboratory (DEAL) Hub is to offer a comprehensive suite of analytical services to support epidemiologists and health researchers conducting studies focusing on the impact of environmental exposures on human health. To this end, the DEAL Developmental Core will address challenges in both developing and standardizing analytical and data processing approaches for assessing health-relevant chemical exposures in relevant media. The Developmental Core will be led by Drs. Lee Ferguson and Gordon Getzinger, who both have significant experience in environmental analytical chemistry of organic and inorganic pollutants, advanced high resolution mass spectrometry techniques, and chemoinformatics. The Developmental Core consists of three specific aims to meet this overarching goal: 1) develop new methods for measuring emerging environmental chemicals of interest, in order to create a client- responsive framework for performing measurements of environmental chemicals in various environmental media; 2) develop novel tools for assessing personal exposure, and advancing holistic chemical exposure assessments; and 3) develop innovative approaches for identification of new environmental contaminants. By achieving these aims, the Developmental Core will embrace the synergistic nature of the DEAL Hub as a whole, collaborating closely with the Environmental Sample Analysis Resource (ESAR) team to enhance its services and deploy newly-developed and validated methods, with the intent to streamline, harmonize, and significantly advance the services provided by DEAL and the broader HHEAR Network.