Develpment Core

开发核心

• 批准号: 10646278
• 负责人: P. Lee Ferguson
• 金额: $ 22.62万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-10 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10646278
• 关键词: Address; Air; Algorithms; Analytical Chemistry; Assessment tool; Biological; Biological Markers; Calibration; Chemical Exposure; Chemicals; Client; Collaborations; Complex; Complex Mixtures; Data; Databases; Detection; Development; Dust; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollutants; Epidemiologist; Evolution; Exposure to; Furniture; Goals; Growth; Health; Human; Individual; Indoor environment; Informatics; Laboratories; Lead; Leadership; Mass Spectrum Analysis; Measurement; Measures; Metadata; Metals; Methods; Molecular; Nature; Organic Chemistry; Outcome; Pathway interactions; Preparation; Probability; Process; Property; Protocols documentation; Research; Research Personnel; Resolution; Resources; Sampling; Serum; Services; Silicones; Source; Standardization; Structure; Techniques; Technology; Testing; Urine; Validation; Work; analytical method; computerized data processing; data reduction; design; environmental chemical; environmental stressor; experience; exposed human population; health assessment; improved; innovation; interest; knowledge integration; laboratory development; manufacture; method development; novel; open source; organic contaminant; pollutant; sensor; tandem mass spectrometry; water environment

PROJECT ABSTRACT The purpose of the Duke Environmental Analysis Laboratory (DEAL) Hub is to offer a comprehensive suite of analytical services to support epidemiologists and health researchers conducting studies focusing on the impact of environmental exposures on human health. To this end, the DEAL Developmental Core will address challenges in both developing and standardizing analytical and data processing approaches for assessing health-relevant chemical exposures in relevant media. The Developmental Core will be led by Drs. Lee Ferguson and Gordon Getzinger, who both have significant experience in environmental analytical chemistry of organic and inorganic pollutants, advanced high resolution mass spectrometry techniques, and chemoinformatics. The Developmental Core consists of three specific aims to meet this overarching goal: 1) develop new methods for measuring emerging environmental chemicals of interest, in order to create a client- responsive framework for performing measurements of environmental chemicals in various environmental media; 2) develop novel tools for assessing personal exposure, and advancing holistic chemical exposure assessments; and 3) develop innovative approaches for identification of new environmental contaminants. By achieving these aims, the Developmental Core will embrace the synergistic nature of the DEAL Hub as a whole, collaborating closely with the Environmental Sample Analysis Resource (ESAR) team to enhance its services and deploy newly-developed and validated methods, with the intent to streamline, harmonize, and significantly advance the services provided by DEAL and the broader HHEAR Network.

项目摘要 杜克大学环境分析实验室 (DEAL) 中心的目的是提供一整套 分析服务，支持流行病学家和卫生研究人员开展重点研究 环境暴露对人类健康的影响。为此，DEAL 发展核心将解决 开发和标准化评估分析和数据处理方法面临的挑战 相关介质中与健康相关的化学物质暴露。发展核心将由博士领导。李 Ferguson 和 Gordon Getzinger 在环境分析化学领域拥有丰富的经验 有机和无机污染物，先进的高分辨率质谱技术，以及 化学信息学。发展核心由三个具体目标组成，以实现这一总体目标：1) 开发测量感兴趣的新兴环境化学品的新方法，以创建客户- 用于在各种环境中执行环境化学品测量的响应框架 媒体; 2) 开发新工具来评估个人暴露并推进整体化学品暴露 评估； 3) 开发识别新环境污染物的创新方法。 通过实现这些目标，发展核心将拥抱 DEAL Hub 作为一个 整体而言，与环境样本分析资源 (ESAR) 团队密切合作，以增强其 服务并部署新开发和验证的方法，旨在简化、协调和 显着推进 DEAL 和更广泛的 HHEAR 网络提供的服务。