Develpment Core

开发核心

• 批准号: 10430119
• 负责人: P. Lee Ferguson
• 金额: $ 22.28万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-10 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10430119
• 关键词: Address; Air; Algorithms; Analytical Chemistry; Biological; Biological Markers; Calibration; Chemical Exposure; Chemicals; Client; Complex; Complex Mixtures; Data; Databases; Detection; Development; Dust; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollution; Epidemiologist; Evolution; Exposure to; Furniture; Goals; Growth; Health; Human; Individual; Indoor environment; Informatics; Knowledge; Laboratories; Lead; Leadership; Logistics; Mass Spectrum Analysis; Measurement; Measures; Metadata; Metals; Methods; Molecular; Nature; Organic Chemistry; Outcome; Pathway interactions; Preparation; Probability; Process; Property; Protocols documentation; Research; Research Personnel; Resolution; Resources; Sampling; Serum; Services; Silicones; Source; Standardization; Structure; Techniques; Technology; Testing; Time; Urine; Validation; Work; analytical method; base; computerized data processing; data reduction; design; environmental chemical; environmental stressor; experience; exposed human population; improved; innovation; interest; laboratory development; method development; novel; open source; organic contaminant; pollutant; sensor; tandem mass spectrometry; tool; water environment

PROJECT ABSTRACT The purpose of the Duke Environmental Analysis Laboratory (DEAL) Hub is to offer a comprehensive suite of analytical services to support epidemiologists and health researchers conducting studies focusing on the impact of environmental exposures on human health. To this end, the DEAL Developmental Core will address challenges in both developing and standardizing analytical and data processing approaches for assessing health-relevant chemical exposures in relevant media. The Developmental Core will be led by Drs. Lee Ferguson and Gordon Getzinger, who both have significant experience in environmental analytical chemistry of organic and inorganic pollutants, advanced high resolution mass spectrometry techniques, and chemoinformatics. The Developmental Core consists of three specific aims to meet this overarching goal: 1) develop new methods for measuring emerging environmental chemicals of interest, in order to create a client- responsive framework for performing measurements of environmental chemicals in various environmental media; 2) develop novel tools for assessing personal exposure, and advancing holistic chemical exposure assessments; and 3) develop innovative approaches for identification of new environmental contaminants. By achieving these aims, the Developmental Core will embrace the synergistic nature of the DEAL Hub as a whole, collaborating closely with the Environmental Sample Analysis Resource (ESAR) team to enhance its services and deploy newly-developed and validated methods, with the intent to streamline, harmonize, and significantly advance the services provided by DEAL and the broader HHEAR Network.

项目摘要 杜克环境分析实验室（DEAL）中心的目的是提供一套全面的 分析服务，以支持流行病学家和卫生研究人员进行研究，重点是 环境暴露对人类健康的影响。为此，DEAL发展核心将解决 在制定和标准化用于评估的分析和数据处理方法方面的挑战 在相关媒介中接触与健康有关的化学品。发展核心将由李博士领导 Ferguson和Gordon Getzinger在环境分析化学方面都有丰富的经验， 有机和无机污染物，先进的高分辨率质谱技术， 化学信息学发展核心包括三个具体目标，以实现这一总体目标：1） 开发新的方法来测量新兴的环境化学品的利益，以创建一个客户端- 用于在各种环境中执行环境化学品测量的响应框架 2）开发新的工具来评估个人暴露，并促进整体化学品暴露 3）开发新的环境污染物识别方法。 通过实现这些目标，发展核心将拥抱交易中心的协同作用， 与环境样品分析资源（ESAR）团队密切合作， 服务和部署新开发和验证的方法，旨在简化，协调， 显著推进由DEAL和更广泛的HHEAR网络提供的服务。