Ophthalmic Therapeutics Engineering Core

眼科治疗工程核心

• 批准号: 10178034
• 负责人: John Andrew MacKay
• 金额: $ 16.65万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10178034
• 关键词: Anterior; Basic Science; Biological; Cellular biology; Center Core Grants; Chemicals; Computers and Advanced Instrumentation; Consultations; Coupled; Custom; Development; Devices; Disease; Drug Delivery Systems; Drug Targeting; Engineering; Experimental Designs; Eye; Formulation; Mechanics; Molecular; Ocular Physiology; Pharmaceutical Preparations; Play; Procedures; Research; Research Personnel; Research Project Grants; Resources; Role; Services; Site; Structure; Technical Expertise; Techniques; Technology; Therapeutic; Ultrasonography; Vision research; design; design and construction; elastography; improved; innovation; innovative technologies; instrument; instrumentation; investigator training; mechanical device; nanoassembly; nanomedicine; novel; novel therapeutic intervention; novel therapeutics; operation; programs; targeted delivery; technology research and development; translational scientist; vision science

Project Summary – Ophthalmic Therapeutics Engineering Core The Ophthalmic Therapeutics Engineering Core will provide essential resources to facilitate translational vision science and technology research for development of new therapies for ocular diseases. The Core will support instrumentation and technical expertise in molecular engineering required to characterize molecular nano- assemblies designed to carry drugs coupled with expertise in device engineering for their targeted delivery or direct therapeutic applications. The availability of shared and centralized resources accelerates the development of new therapeutic approaches to efficiently and effectively deliver therapies precisely to specific sites in the eye, using innovative technologies. The integrated resources of the Core will play an essential role in bridging basic science, engineering, and translational vision research for developing novel ocular therapeutic approaches. The specific aims are to provide instrumentation and technical expertise for: 1) developing, characterizing and optimizing biological, chemical, or mechanical drug delivery systems; 2) designing and fabricating custom devices and instruments that can improve or advance experimental procedures and research capabilities of investigators, particularly those involving delivery of therapeutics; 3) training investigators on the utility and operation of available instrumentation for the design and characterization of therapeutic drug delivery vehicles and devices; and 4) consultations on the experimental design, appropriateness of the specific techniques, and integration of engineering techniques to escalate the progress of vision research projects.

项目摘要 - 眼科治疗工程核心 眼科治疗工程核心将为促进转化视觉提供必要的资源 开发眼科疾病新疗法的科学技术研究。核心将支持 表征分子纳米所需的分子工程仪器和技术专业知识 设计用于携带药物的组件与设备工程专业知识相结合，以实现靶向输送或 直接治疗应用。共享和集中资源的可用性加速了 开发新的治疗方法，以高效且有效地将治疗精确地递送至特定部位 使用创新技术。核心整合资源将发挥重要作用 架起基础科学、工程和转化视觉研究的桥梁，以开发新型眼部治疗方法 接近。具体目标是为以下方面提供仪器和技术专业知识：1）开发、 表征和优化生物、化学或机械药物输送系统； 2）设计和 制造可以改进或推进实验程序的定制设备和仪器， 研究人员的研究能力，特别是涉及治疗药物的研究能力； 3）培训 研究人员研究用于设计和表征的可用仪器的实用性和操作 治疗药物输送载体和装置； 4）实验设计咨询， 具体技术的适当性以及工程技术的集成以升级进度 视觉研究项目。