Ophthalmic Therapeutics Engineering Core

眼科治疗工程核心

• 批准号: 9788482
• 负责人: John Andrew MacKay
• 金额: $ 16.65万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9788482
• 关键词: Anterior; Basic Science; Biological; Cellular biology; Center Core Grants; Chemicals; Computers and Advanced Instrumentation; Consultations; Coupled; Custom; Development; Devices; Disease; Drug Delivery Systems; Drug Targeting; Engineering; Experimental Designs; Eye; Formulation; Mechanics; Molecular; Ocular Physiology; Pharmaceutical Preparations; Play; Procedures; Research; Research Personnel; Research Project Grants; Resources; Role; Services; Site; Structure; Technical Expertise; Techniques; Technology; Therapeutic; Ultrasonography; Vision research; design; design and construction; elastography; improved; innovation; innovative technologies; instrument; instrumentation; investigator training; nanoassembly; nanomedicine; novel; novel therapeutic intervention; novel therapeutics; operation; programs; targeted delivery; technology research and development; translational scientist; vision science

Project Summary – Ophthalmic Therapeutics Engineering Core The Ophthalmic Therapeutics Engineering Core will provide essential resources to facilitate translational vision science and technology research for development of new therapies for ocular diseases. The Core will support instrumentation and technical expertise in molecular engineering required to characterize molecular nano- assemblies designed to carry drugs coupled with expertise in device engineering for their targeted delivery or direct therapeutic applications. The availability of shared and centralized resources accelerates the development of new therapeutic approaches to efficiently and effectively deliver therapies precisely to specific sites in the eye, using innovative technologies. The integrated resources of the Core will play an essential role in bridging basic science, engineering, and translational vision research for developing novel ocular therapeutic approaches. The specific aims are to provide instrumentation and technical expertise for: 1) developing, characterizing and optimizing biological, chemical, or mechanical drug delivery systems; 2) designing and fabricating custom devices and instruments that can improve or advance experimental procedures and research capabilities of investigators, particularly those involving delivery of therapeutics; 3) training investigators on the utility and operation of available instrumentation for the design and characterization of therapeutic drug delivery vehicles and devices; and 4) consultations on the experimental design, appropriateness of the specific techniques, and integration of engineering techniques to escalate the progress of vision research projects.

项目摘要 - 眼科治疗工程核心 眼科治疗工程核心将提供基本资源以促进转化愿景 科学技术研究开发新疗法的眼部疾病。核心将支持 表征分子纳米 - 旨在携带药物以及设备工程方面的专业知识的组件，用于其目标交付或 直接治疗应用。共享和集中资源的可用性加速了 开发新的治疗方法，以有效有效地将疗法精确提供给特定 使用创新技术，眼中的站点。核心的综合资源将发挥重要作用 在桥接基础科学，工程和转化视觉研究中，用于开发新型眼疗 方法。具体目的是为：1）开发， 表征和优化生物学，化学或机械药物输送系统； 2）设计和 制造可以改善或提高实验程序的定制设备和仪器 研究人员的研究能力，特别是涉及治疗的研究能力； 3）培训 研究人员关于可用仪器的实用性和操作，以设计和表征 治疗药物和设备； 4）关于实验设计的咨询， 特定技术的适当性以及工程技术的整合以升级进度 视觉研究项目。