Digital Markers of Cognition Across the Spectrum of Preclinical Cognitive Impairment to Dementia

痴呆症临床前认知障碍范围内的认知数字标记

• 批准号: 10190755
• 负责人: Stacy Andersen
• 金额: $ 11.91万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10190755
• 关键词: Aging; Applications Grants; Award; Behavioral; Biometry; Boston; Brain; Brain Pathology; Characteristics; Clinical; Cognition; Cognitive; Cognitive aging; Cohort Studies; Collaborations; Communication; Complement; Computer software; Data; Data Collection; Dementia; Development; Diagnostic; Diffusion; Digital Signal Processing; Early Diagnosis; Early Intervention; Early treatment; Epidemiologist; Family; Family Study; Family member; Five-Year Plans; Framingham Heart Study; Functional Magnetic Resonance Imaging; Funding; General Population; Genetic; Gerontology; Goals; Grant; Hippocampus (Brain); Human; Image; Impaired cognition; Impairment; Incidence; Individual; Institutes; Investigation; K-Series Research Career Programs; Knowledge; Life; Linguistics; Literature; Longevity; Magnetic Resonance Imaging; Measures; Medicine; Mentors; Mentorship; Methods; Motor; Nerve Degeneration; Neurodegenerative Disorders; Neuropsychological Tests; Neuropsychology; Participant; Pattern; Performance; Persons; Phenotype; Physical Function; Process; Production; Protocols documentation; Publishing; Research; Rest; Semantics; Sensitivity and Specificity; Speech; Speed; Statistical Data Interpretation; Structure; Study Subject; Technology; Testing; Thick; Training; Translations; Tremor; Universities; Variant; Voice; Work; Writing; apprenticeship; base; behavior measurement; career; career development; clinical phenotype; clinically relevant; cognitive change; cognitive function; cognitive performance; cohort; computerized; connectome; digital; effective intervention; experience; follow-up; healthspan; healthy aging; indexing; informal learning; medical schools; meetings; neural network; neuroimaging; neuroimaging marker; neuropsychiatry; novel; performance tests; pre-clinical; predictive marker; preservation; professor; prospective; resilience; response; skills; voice recognition; white matter

ABSTRACT Stacy L. Andersen is an Assistant Professor in the Department of Medicine at Boston University School of Medicine. She seeks a mentored career development award (K01) to obtain critical knowledge skills in biostatistics, communication patterns, neuropsychological assessment, and neuroimaging, particularly as they relate to cognitive aging, and necessary research experience leading to an independent career as a neuroscientist in field of aging research, specifically in the field of healthy aging and cognitive resilience. The training proposal details a five-year plan of formal and informal instruction in the pathophysiologic basis of brain changes associated with aging and neurodegenerative disease as well as training in biostatistics and analysis methods. Dr. Andersen’s mentors, established experts in the fields of neuropsychology, neuroimaging, and gerontology have met with Dr. Andersen to formulate a plan of course work, guided study, seminars and academic meetings. Short-term career goals include to complete course work in linguistics, neuroimaging methods, and statistical analysis, disseminate high quality mentored research findings via presentations and published works, engage in career development activities and to apply for independent R grant funding early in the fifth year of the award period. Long-term career goals are to be an independent neuropsychiatric epidemiologist with content expertise in the neuropsychological assessment of long-lived individuals, novel applications of technology for evaluating cognitive function, and factors associated with cognitive resilience. The specific aims of the proposed research are to (1) with specialized software, extract cognitive performance metrics from digital voice recordings and digitally-captured motor performance, (2) test the hypothesis that digital metrics of speech and motor production are sensitive to variations in cognitive function and clinical dementia status, (3) test the hypothesis that digital metrics of speech and motor production are associated with neuroanatomical substrates as detected by structural and functional MRI, and (4) institute prospective data collection of longitudinal, digitally-acquired neuropsychological test data. This study has the potential to identify digital metrics as correlates of cognitive function and possibly early markers of cognitive change allowing for earlier diagnosis and intervention. Completion of the proposed aims will provide preliminary findings that will lay the groundwork for a grant application investigating the association of longitudinal changes in traditional and digital neuropsychological metrics with incidence of cognitive impairment and dementia as well as the factors associated with an absence of longitudinal cognitive change (i.e., cognitive resilience).

抽象的 Stacy L. Andersen是波士顿大学学校医学系的助理教授 药品。她寻求职业发展奖（K01）的问题，以获得关键的知识技能 生物统计学，沟通模式，神经心理学评估和神经影像学，尤其是 与认知衰老和必要的研究经验有关，导致独立职业 衰老研究领域的神经科学家，特别是在健康的衰老和认知弹性领域。 培训建议详细介绍了一个五年的正式和非正式教学计划 与衰老和神经退行性疾病以及生物统计学和培训有关的大脑变化 分析方法。 Andersen博士的导师是神经心理学领域的专家， 神经影像学和老年医学与安德森博士会面，以制定一项计划工作的计划，指导性研究， 下水道和学术会议。短期职业目标包括完成语言学课程， 神经影像学方法和统计分析通过 演讲和发表的作品，从事职业发展活动并申请独立R 在奖励期的第五年初授予资金。长期职业目标是成为独立的 神经心理流行病学家具有长期神经心理学评估的内容专业知识 个人，技术在评估认知功能方面的新应用以及与之相关的因素 认知弹性。 拟议研究的具体目的是（1）使用专业软件，提取认知 数字语音录音和数字捕捉电动机性能的性能指标，（2）测试 假设语音和运动生产的数字指标对认知功能的变化敏感 和临床痴呆状态，（3）检验了语音和运动生产数字指标的假设是 与结构和功能性MRI检测到的神经解剖底物相关，（4）研究所 纵向，数字化神经心理学测试数据的前瞻性数据收集。这项研究有 将数字指标识别为认知功能的相关性和认知早期标记的潜力 更改允许早期诊断和干预。 拟议目标的完成将提供初步发现，这将为赠款奠定基础 调查传统和数字神经心理学纵​​向变化的关联 认知障碍和痴呆的发生率以及与吸收相关的因素的指标 纵向认知变化（即认知弹性）。