Digital Markers of Cognition Across the Spectrum of Preclinical Cognitive Impairment to Dementia

痴呆症临床前认知障碍范围内的认知数字标记

• 批准号: 10190755
• 负责人: Stacy Andersen
• 金额: $ 11.91万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10190755
• 关键词: Aging; Applications Grants; Award; Behavioral; Biometry; Boston; Brain; Brain Pathology; Characteristics; Clinical; Cognition; Cognitive; Cognitive aging; Cohort Studies; Collaborations; Communication; Complement; Computer software; Data; Data Collection; Dementia; Development; Diagnostic; Diffusion; Digital Signal Processing; Early Diagnosis; Early Intervention; Early treatment; Epidemiologist; Family; Family Study; Family member; Five-Year Plans; Framingham Heart Study; Functional Magnetic Resonance Imaging; Funding; General Population; Genetic; Gerontology; Goals; Grant; Hippocampus (Brain); Human; Image; Impaired cognition; Impairment; Incidence; Individual; Institutes; Investigation; K-Series Research Career Programs; Knowledge; Life; Linguistics; Literature; Longevity; Magnetic Resonance Imaging; Measures; Medicine; Mentors; Mentorship; Methods; Motor; Nerve Degeneration; Neurodegenerative Disorders; Neuropsychological Tests; Neuropsychology; Participant; Pattern; Performance; Persons; Phenotype; Physical Function; Process; Production; Protocols documentation; Publishing; Research; Rest; Semantics; Sensitivity and Specificity; Speech; Speed; Statistical Data Interpretation; Structure; Study Subject; Technology; Testing; Thick; Training; Translations; Tremor; Universities; Variant; Voice; Work; Writing; apprenticeship; base; behavior measurement; career; career development; clinical phenotype; clinically relevant; cognitive change; cognitive function; cognitive performance; cohort; computerized; connectome; digital; effective intervention; experience; follow-up; healthspan; healthy aging; indexing; informal learning; medical schools; meetings; neural network; neuroimaging; neuroimaging marker; neuropsychiatry; novel; performance tests; pre-clinical; predictive marker; preservation; professor; prospective; resilience; response; skills; voice recognition; white matter

ABSTRACT Stacy L. Andersen is an Assistant Professor in the Department of Medicine at Boston University School of Medicine. She seeks a mentored career development award (K01) to obtain critical knowledge skills in biostatistics, communication patterns, neuropsychological assessment, and neuroimaging, particularly as they relate to cognitive aging, and necessary research experience leading to an independent career as a neuroscientist in field of aging research, specifically in the field of healthy aging and cognitive resilience. The training proposal details a five-year plan of formal and informal instruction in the pathophysiologic basis of brain changes associated with aging and neurodegenerative disease as well as training in biostatistics and analysis methods. Dr. Andersen’s mentors, established experts in the fields of neuropsychology, neuroimaging, and gerontology have met with Dr. Andersen to formulate a plan of course work, guided study, seminars and academic meetings. Short-term career goals include to complete course work in linguistics, neuroimaging methods, and statistical analysis, disseminate high quality mentored research findings via presentations and published works, engage in career development activities and to apply for independent R grant funding early in the fifth year of the award period. Long-term career goals are to be an independent neuropsychiatric epidemiologist with content expertise in the neuropsychological assessment of long-lived individuals, novel applications of technology for evaluating cognitive function, and factors associated with cognitive resilience. The specific aims of the proposed research are to (1) with specialized software, extract cognitive performance metrics from digital voice recordings and digitally-captured motor performance, (2) test the hypothesis that digital metrics of speech and motor production are sensitive to variations in cognitive function and clinical dementia status, (3) test the hypothesis that digital metrics of speech and motor production are associated with neuroanatomical substrates as detected by structural and functional MRI, and (4) institute prospective data collection of longitudinal, digitally-acquired neuropsychological test data. This study has the potential to identify digital metrics as correlates of cognitive function and possibly early markers of cognitive change allowing for earlier diagnosis and intervention. Completion of the proposed aims will provide preliminary findings that will lay the groundwork for a grant application investigating the association of longitudinal changes in traditional and digital neuropsychological metrics with incidence of cognitive impairment and dementia as well as the factors associated with an absence of longitudinal cognitive change (i.e., cognitive resilience).

摘要 斯泰西湖安德森是波士顿大学医学院医学系的助理教授， 药她寻求指导职业发展奖（K01），以获得关键的知识技能， 生物统计学、沟通模式、神经心理学评估和神经影像学，特别是当它们 与认知老化有关，以及必要的研究经验，导致独立的职业生涯， 神经科学家在老龄化研究领域，特别是在健康老龄化和认知弹性领域。 该培训计划详细介绍了病理生理学基础的正式和非正式教学的五年计划 与衰老和神经退行性疾病相关的大脑变化以及生物统计学的培训， 分析方法安德森博士的导师，神经心理学领域的专家， 神经影像学和老年学与安德森博士会面，制定课程工作计划，指导学习， 研讨会和学术会议。短期职业目标包括完成语言学课程， 神经影像学方法和统计分析，传播高质量的指导研究结果，通过 演讲和发表作品，从事职业发展活动，并申请独立R 在奖励期的第五年早期提供赠款。长期的职业目标是成为一名独立的 神经精神病学流行病学家，在长期生活的神经心理学评估方面具有内容专业知识 个体，评估认知功能的技术的新应用，以及与 认知复原力 本研究的具体目标是：（1）利用专门的软件， 来自数字语音记录和数字捕获的运动性能的性能指标，（2）测试 言语和运动产生的数字度量对认知功能的变化敏感的假设 和临床痴呆状态，（3）测试语音和运动产生的数字指标是 与结构和功能MRI检测到的神经解剖基质相关，以及（4）研究所 纵向的、数字化获得的神经心理学测试数据的前瞻性数据收集。这项研究有 有可能将数字指标识别为认知功能的相关因素，并可能是认知功能的早期标志物。 改变，以便早期诊断和干预。 完成拟议目标将提供初步调查结果，为赠款奠定基础 应用调查纵向变化的传统和数字神经心理学的关联 认知障碍和痴呆的发生率以及与缺席相关的因素 纵向认知变化（即，认知弹性）。