Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO)

百岁老人及其后代对阿尔茨海默病的抵抗力/抵抗力 (RADCO)

基本信息

批准号：
10532568
负责人：
Stacy Andersen
金额：
$ 33.3万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10532568
关键词：
Address Administrative Supplement African American African American population Age Aging Alzheimer&apos s Disease Alzheimer’s disease biomarker Amyloid beta-42 Anatomy Area Autopsy Binding Sites Biological Blood specimen Boston Brain Brain imaging COVID-19 Centenarian Characteristics Clinical Data Cognition Cognitive Collection Communities Consensus Data Data Analyses Data Collection Databases Diffusion Magnetic Resonance Imaging Disease Marker Enrollment Ensure Fasting Funding Future Gene Expression Generations Genetic Markers Genetic Transcription Goals Heart Hispanic Human Image Image Analysis Impaired cognition Impairment International Investigation Knowledge Portal Lead Light Link Location Longevity Los Angeles Magnetic Resonance Imaging Measures Memory Mission Modality Modeling Molecular Morphologic artifacts Neurocognitive Neuropsychological Tests Neuropsychology New York City Noise Outcome Output Parents Participant Pathologic Patient Recruitments Phenotype Physiologic pulse Plasma Population Predisposition RNA Race Resistance Resolution Resource Sharing Rest Sampling Sampling Studies Scanning Secure Septuagenarian Site Spouses Standardization Statistical Data Interpretation Structure System Techniques Testing Time Tissues Training Travel Universities Utah Work aged arterial spin labeling base biobank cognitive ability cognitive function cohort connectome cytokine data acquisition data de-identification data integration data management data repository data sharing design experience image processing imaging facilities metropolitan neurofilament neuroimaging neuropathology normal aging offspring parent grant parent project participant enrollment phenotypic biomarker phenotypic data preservation prisma recruit research study resilience statistics success symposium time interval tool transcriptomics virtual willingness

项目摘要

PROJECT SUMMARY/ABSTRACT The NIA funded parent project, 1U19AG073172, “Resilience/Resistance to Alzheimer’s Disease in Centenarians and their Offspring (RADCO)” seeks to characterize cognitive resilience or brain resistance to AD and to discover the underlying and hopefully translatable biological mechanisms that enable centenarian cognitive superagers to maintain cognitive function typical of cognitively intact septuagenarians. To address reviewers’ concerns that African Americans (n=88 or 7.2%) are underrepresented in the RADCO sample and that too few centenarians (n=75 or 15% of the total neuroimaged sample) undergo neuroimaging, this administrative supplement application seeks to fund a fourth phenotyping and biospecimen core and neuroimaging core site at Georgia State University (GSU). The GSU site will enhance the diversity of the RADCO cohort by enrolling 234 African Americans, thus increasing the proportion of the RADCO sample that is African American from 7.2% (88/1216) to 22.2% (322/1450). GSU is also able to be a fourth neuroimaging site for RADCO as it has a Prisma MRI platform and routinely performs the key structural and resting state functional pulse sequences that are identical to those used by the three current neuroimaging centers of the Neuroimaging Core as well as the Human Connectome-Aging project. We anticipate that about half (n=103) of the Atlanta-based participants will undergo neuroimaging. Of these 103 additional neuroimaged participants, we estimate 44 will be centenarians. These 44 centenarians added to the RADCO-wide sample of 150 centenarians will bring the proportion of centenarians who are neuroimaged to 34% (194/573). Dr. Vonetta Dotson’s expertise and demonstrated success in engaging the local African American community for enrollment in research studies provides RADCO with the opportunity to substantially increase our African American participant enrollment that will provide an adequately powered sample to discern race-specific differences and similarities in determinants or markers of cognitive superaging. The conduct of this African American participant enrollment effort at GSU provides the added benefit and rare opportunity to collaborate with the Georgia State/Georgia Tech Center for Advanced Brain Imaging (CABI), led by Vince Calhoun, to increase our sample of participants undergoing the rigorously standardized neuroimaging component of the Study.

项目摘要/摘要 NIA资助的家长项目，1U19AG073172，“对阿尔茨海默氏病的韧性/抵抗力百岁老人及其后代（radco）试图表征认知的韧性或对AD的抗性并发现能够使百年纪念的基本且有望翻译的生物学机制认知超级词，以维持认知完整的Septugenarians的认知功能。解决审稿人担心非裔美国人（n = 88或7.2％）在Radco样本中的代表性不足和一百岁的人很少（n = 75或15％的神经影像学样本）经历神经影像学，这行政补充申请旨在资助第四个表型和生物循环核心，以及佐治亚州立大学（GSU）的神经影像学位。 GSU站点将增强通过招募234名非裔美国人，Radco队列增加了RADCO样本的比例非裔美国人是7.2％（88/1216）至22.2％（322/1450）。 GSU也能够成为第四个神经影像 RADCO的站点，因为它具有Prisma MRI平台，并经常执行关键结构和休息状态功能脉冲序列与三个当前神经成像中心所使用的序列相同神经影像核心以及人类连接范围的项目。我们预计大约一半（n = 103）总部位于亚特兰大的参与者将经历神经影像学。在这103位神经影像参与者中，我们估计44名是百岁老人。这44位百年代人添加到150的Radco范围的样本中百岁老人将将神经成像的百岁老人比例提高到34％（194/573）。 Vonetta博士 Dotson的专业知识并在吸引当地非裔美国人社区方面取得了成功研究研究的入学使Radco有机会大大增加我们的非洲人美国参与者的入学人数将提供足够动力的样本来辨别特定于种族的确定性或认知超级标记的差异和相似性。这个非洲的行为 GSU的美国参与者招生工作提供了额外的好处和难得的合作机会由佐治亚州/佐治亚州高级脑成像技术中心（CABI），由文斯·卡尔霍恩（Vince Calhoun）领导增加我们经历了严格标准化神经影像成分的参与者样本学习。