Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO)

项目摘要/摘要 NIA资助的父项目1U19AG073172，“对阿尔茨海默病的复原力/抵抗力” 百岁老人及其后代(RADCO)试图描述认知韧性或大脑对阿尔茨海默病的抵抗 并发现潜在的，希望可以翻译的生物机制，使百岁老人 认知超人维持认知正常的七十多岁老人的典型认知功能。致信地址 审查者担心非裔美国人(n=88或7.2%)在RADCO样本中代表性不足 接受神经成像检查的百岁老人太少了(n=75%或15%)。 行政补充申请寻求资助第四个表型和生物素核心和 佐治亚州立大学(GSU)神经成像核心站点。格拉斯哥州立大学的选址将增强 通过招募234名非裔美国人进行RADCO队列，从而增加了RADCO样本中 非裔美国人从7.2%(88/1216)下降到22.2%(322/1450)。格拉斯哥州立大学也能够成为第四个神经成像 RADCO的场地，因为它有一个Prisma MRI平台，并定期执行关键的结构和休息状态 功能脉冲序列与目前三个神经成像中心使用的序列相同 神经成像核心以及人类连接-衰老项目。我们预计大约有一半(n=103) 亚特兰大的参与者将接受神经成像。在这103名额外的神经成像参与者中， 我们估计将有44位百岁老人。这44名百岁老人是在RADCO全样本150人的基础上增加的 百岁老人将使接受神经成像的百岁老人比例达到34%(194/573)。沃内塔博士 多特森的专业知识和成功地吸引了当地的非裔美国人社区 参加研究性学习为RADCO提供了大幅增加我们非洲人 美国参与者登记，将提供足够有力的样本来区分特定种族 认知超龄的决定因素或标志物的异同。这个非洲人的行为 GSU的美国参与者注册工作提供了额外的好处和难得的合作机会 与文斯·卡尔霍恩领导的佐治亚州/佐治亚州高级脑成像技术中心(CABI)合作， 增加接受严格标准化的神经成像部分的参与者的样本 学习。

PROJECT SUMMARY/ABSTRACT The NIA funded parent project, 1U19AG073172, “Resilience/Resistance to Alzheimer’s Disease in Centenarians and their Offspring (RADCO)” seeks to characterize cognitive resilience or brain resistance to AD and to discover the underlying and hopefully translatable biological mechanisms that enable centenarian cognitive superagers to maintain cognitive function typical of cognitively intact septuagenarians. To address reviewers’ concerns that African Americans (n=88 or 7.2%) are underrepresented in the RADCO sample and that too few centenarians (n=75 or 15% of the total neuroimaged sample) undergo neuroimaging, this administrative supplement application seeks to fund a fourth phenotyping and biospecimen core and neuroimaging core site at Georgia State University (GSU). The GSU site will enhance the diversity of the RADCO cohort by enrolling 234 African Americans, thus increasing the proportion of the RADCO sample that is African American from 7.2% (88/1216) to 22.2% (322/1450). GSU is also able to be a fourth neuroimaging site for RADCO as it has a Prisma MRI platform and routinely performs the key structural and resting state functional pulse sequences that are identical to those used by the three current neuroimaging centers of the Neuroimaging Core as well as the Human Connectome-Aging project. We anticipate that about half (n=103) of the Atlanta-based participants will undergo neuroimaging. Of these 103 additional neuroimaged participants, we estimate 44 will be centenarians. These 44 centenarians added to the RADCO-wide sample of 150 centenarians will bring the proportion of centenarians who are neuroimaged to 34% (194/573). Dr. Vonetta Dotson’s expertise and demonstrated success in engaging the local African American community for enrollment in research studies provides RADCO with the opportunity to substantially increase our African American participant enrollment that will provide an adequately powered sample to discern race-specific differences and similarities in determinants or markers of cognitive superaging. The conduct of this African American participant enrollment effort at GSU provides the added benefit and rare opportunity to collaborate with the Georgia State/Georgia Tech Center for Advanced Brain Imaging (CABI), led by Vince Calhoun, to increase our sample of participants undergoing the rigorously standardized neuroimaging component of the Study.