Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO)

百岁老人及其后代对阿尔茨海默病的抵抗力/抵抗力 (RADCO)

• 批准号: 10532568
• 负责人: Stacy Andersen
• 金额: $ 33.3万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10532568
• 关键词: Address; Administrative Supplement; African American; African American population; Age; Aging; Alzheimer' s Disease; Alzheimer’s disease biomarker; Amyloid beta-42; Anatomy; Area; Autopsy; Binding Sites; Biological; Blood specimen; Boston; Brain; Brain imaging; COVID-19; Centenarian; Characteristics; Clinical Data; Cognition; Cognitive; Collection; Communities; Consensus; Data; Data Analyses; Data Collection; Databases; Diffusion Magnetic Resonance Imaging; Disease Marker; Enrollment; Ensure; Fasting; Funding; Future; Gene Expression; Generations; Genetic Markers; Genetic Transcription; Goals; Heart; Hispanic; Human; Image; Image Analysis; Impaired cognition; Impairment; International; Investigation; Knowledge Portal; Lead; Light; Link; Location; Longevity; Los Angeles; Magnetic Resonance Imaging; Measures; Memory; Mission; Modality; Modeling; Molecular; Morphologic artifacts; Neurocognitive; Neuropsychological Tests; Neuropsychology; New York City; Noise; Outcome; Output; Parents; Participant; Pathologic; Patient Recruitments; Phenotype; Physiologic pulse; Plasma; Population; Predisposition; RNA; Race; Resistance; Resolution; Resource Sharing; Rest; Sampling; Sampling Studies; Scanning; Secure; Septuagenarian; Site; Spouses; Standardization; Statistical Data Interpretation; Structure; System; Techniques; Testing; Time; Tissues; Training; Travel; Universities; Utah; Work; aged; arterial spin labeling; base; biobank; cognitive ability; cognitive function; cohort; connectome; cytokine; data acquisition; data de-identification; data integration; data management; data repository; data sharing; design; experience; image processing; imaging facilities; metropolitan; neurofilament; neuroimaging; neuropathology; normal aging; offspring; parent grant; parent project; participant enrollment; phenotypic biomarker; phenotypic data; preservation; prisma; recruit; research study; resilience; statistics; success; symposium; time interval; tool; transcriptomics; virtual; willingness

PROJECT SUMMARY/ABSTRACT The NIA funded parent project, 1U19AG073172, “Resilience/Resistance to Alzheimer’s Disease in Centenarians and their Offspring (RADCO)” seeks to characterize cognitive resilience or brain resistance to AD and to discover the underlying and hopefully translatable biological mechanisms that enable centenarian cognitive superagers to maintain cognitive function typical of cognitively intact septuagenarians. To address reviewers’ concerns that African Americans (n=88 or 7.2%) are underrepresented in the RADCO sample and that too few centenarians (n=75 or 15% of the total neuroimaged sample) undergo neuroimaging, this administrative supplement application seeks to fund a fourth phenotyping and biospecimen core and neuroimaging core site at Georgia State University (GSU). The GSU site will enhance the diversity of the RADCO cohort by enrolling 234 African Americans, thus increasing the proportion of the RADCO sample that is African American from 7.2% (88/1216) to 22.2% (322/1450). GSU is also able to be a fourth neuroimaging site for RADCO as it has a Prisma MRI platform and routinely performs the key structural and resting state functional pulse sequences that are identical to those used by the three current neuroimaging centers of the Neuroimaging Core as well as the Human Connectome-Aging project. We anticipate that about half (n=103) of the Atlanta-based participants will undergo neuroimaging. Of these 103 additional neuroimaged participants, we estimate 44 will be centenarians. These 44 centenarians added to the RADCO-wide sample of 150 centenarians will bring the proportion of centenarians who are neuroimaged to 34% (194/573). Dr. Vonetta Dotson’s expertise and demonstrated success in engaging the local African American community for enrollment in research studies provides RADCO with the opportunity to substantially increase our African American participant enrollment that will provide an adequately powered sample to discern race-specific differences and similarities in determinants or markers of cognitive superaging. The conduct of this African American participant enrollment effort at GSU provides the added benefit and rare opportunity to collaborate with the Georgia State/Georgia Tech Center for Advanced Brain Imaging (CABI), led by Vince Calhoun, to increase our sample of participants undergoing the rigorously standardized neuroimaging component of the Study.

项目总结/摘要 NIA资助的母项目，1U 19 AG 073172，“老年痴呆症的恢复力/抵抗力”， 百岁老人和他们的后代（RADCO）”试图描述认知弹性或大脑对AD的抵抗力， 并发现潜在的、有望转化的生物学机制， 认知超级老人来维持七十岁老人典型的认知功能。解决 评审员担心非裔美国人（n=88或7.2%）在RADCO样本中代表性不足， 太少的百岁老人（n=75或总神经成像样本的15%）接受神经成像， 行政补充申请寻求资助第四个表型和生物标本核心， 格鲁吉亚州立大学（GSU）的神经影像学核心站点。GSU网站将增强 RADCO队列通过招募234名非洲裔美国人，从而增加RADCO样本的比例， 非裔美国人从7.2%（88/1216）到22.2%（322/1450）。GSU也可以成为第四种神经成像 RADCO的研究中心，因为它有一个Prisma MRI平台，并定期执行关键的结构和静息状态 功能性脉冲序列，其与由美国神经科学院的三个当前神经成像中心所使用的那些相同。 神经影像学核心以及人类连接体老化项目。我们预计，大约一半（n=103）的 在亚特兰大的参与者将接受神经成像。在这103名额外的神经成像参与者中， 我们估计会有44位百岁老人这44名百岁老人加入了RADCO范围内的150名样本 百岁老人将使百岁老人接受神经成像的比例达到34%（194/573）。沃内塔医生 Dotson的专业知识和成功的参与当地非裔美国人社区， 参加研究性学习为RADCO提供了大幅增加我们非洲 美国参与者招募，将提供足够的样本来辨别种族特异性 认知超老化的决定因素或标志的差异和相似性。这个非洲人的行为 GSU的美国参与者注册工作提供了额外的好处和难得的合作机会 与文斯·卡尔霍恩领导的格鲁吉亚州/格鲁吉亚高级脑成像技术中心（CABI）合作， 增加我们的样本参与者进行严格标准化的神经影像学组成部分， Study.