Phenotyping and Biospecimen Core

表型分析和生物样本核心

• 批准号: 10276393
• 负责人: Stacy Andersen
• 金额: $ 149.07万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10276393
• 关键词: Affect; Age; Alzheimer' s Disease; Alzheimer’s disease biomarker; Amyloid beta-42; Anatomy; Area; Autopsy; Biological; Biological Assay; Blood specimen; Boston; Brain; COVID-19; Centenarian; Clinical Data; Cognitive; Consensus; Data; Data Collection; Dementia; Diagnosis; Disease Marker; Eligibility Determination; Enrollment; Ensure; Familiarity; Fasting; Funding; Future; Gene Expression; Genetic Markers; Genetic Transcription; Impaired cognition; Impairment; Investigation; Knowledge Portal; Lead; Link; Longevity; Los Angeles; Measures; Mission; Modeling; Molecular; Neurocognitive; Neuropsychological Tests; Neuropsychology; New York City; Outcome; Participant; Pathologic; Patient Recruitments; Phenotype; Plasma; RNA; Research Personnel; Resistance; Resource Sharing; Resources; Sampling; Scanning; Secure; Spouses; Statistical Data Interpretation; System; Time; Tissues; Work; base; biobank; cognitive function; cytokine; data de-identification; data management; data sharing; exome; experience; innovation; neuroimaging; neuropathology; offspring; phenotypic biomarker; phenotypic data; protective factors; recruit; resilience; success; symposium; tool; transcriptomics; virtual

The Phenotyping and Biospecimen (P&B) Core's primary mission is to leverage two NIA-funded centenarian studies by sifting through their study participants in identifying centenarian cognitive superagers, offspring and offspring spouses for enrollment in the RADCO study, extending their phenotyping with annual uniform neuropsychological testing, plasma biomarkers of Alzheimer's disease (AD), and facilitating and facilitating neuroimaging and post-mortem neuropathological studies among willing participants. The P&B Core's successful conduct of its six aims is critical to RADCO's investigation of centenarians and their offspring as models of cognitive resilience and resistance to cognitive impairment and AD. Those 6 Specific Aims are: Specific Aim 1. Establish a cognitive superagers (n=496, ages 100-110 years), offspring (n=600), and offspring spouses (n=120) sample with baseline neuropsychological assessments, other phenotypic data, blood samples, and genetic and biomarker data provided by 2 ongoing NIA-funded centenarian studies. Specific Aim 2. Perform annual Covid-19-safe virtual neurocognitive assessments and other phenotypic data collection that are uniform with the ILO study and LCCP measures. Also, to enhance accuracy of the neurocognitive assessments by performing interdisciplinary expert diagnoses consensus conferences. Specific Aim 3. Employing REDCap, manage and perform QC, and make easily but securely available all of the data collected and generated by the RADCO Cores and Projects, including the neuropsychological, neuroimaging, neuropathologic phenotype and biomarker and transcriptomic data. Specific Aim 4. To receive from the ILO+LCCP studies and then longitudinally collect blood samples (centenarians annually, offspring and offspring spouses every other year) from RADCO participants for use by the two projects. To maintain samples in a biorepository as a sharable resource. Specific Aim 5. Support the RADCO Neuroimaging Core's aims by recruiting RADCO participants for local neuroimaging and linking scan data to clinical data. Specific Aim 6. Recruit RADCO participants for future brain donation, ensure that autopsies proceed smoothly, and link clinical data to anatomic, pathologic and molecular data generated by the P&B neuropathology efforts. These data will inform the resilient and resistant phenotypes delineated in Project 1. Brain area-specific tissues will be provided for RNA expression studies in Project 2.

表型鉴定和生物学家(P&B)核心的主要任务是利用NIA资助的两名百岁老人 通过筛选研究参与者来确定百岁认知超级老年人、后代和 参加RADCO研究的子女配偶，延长他们的表型，穿上年度制服 神经心理测试，阿尔茨海默病(AD)的血浆生物标志物，以及促进和促进 自愿受试者的神经影像和死后神经病理学研究。P&B Core的 其六个目标的成功实施对于RADCO对百岁老人及其后代的调查至关重要 认知复原力和对认知障碍和AD的抵抗的模型。这6个具体目标是： 具体目标1.建立认知超级老年人(n=496，年龄100-110岁)、子代(n=600)和子代 配偶(n=120)样本，包括基线神经心理评估、其他表型数据、血样、 以及由NIA资助的两项正在进行的百岁老人研究提供的遗传和生物标记数据。具体目标2.执行 年度新冠肺炎安全虚拟神经认知评估和其他统一的表型数据收集 与劳工组织的研究和LCCP措施相一致。此外，为了提高神经认知评估的准确性， 召开跨学科专家诊断共识会议。具体目标3.聘用红帽， 管理和执行质量控制，并轻松但安全地使用由收集和生成的所有数据 RADCO核心和项目，包括神经心理学、神经成像、神经病理表型和 生物标志物和转录组数据。具体目标4.接受劳工组织+LCCP的研究，然后 纵向采集血样(百岁老人每年采集一次，后代及其配偶每隔一年采集一次) 来自RADCO参与者的数据，供两个项目使用。将生物储存库中的样本作为可共享的 资源。具体目标5.通过招募RADCO参与者来支持RADCO神经成像核心的目标 局部神经成像和将扫描数据与临床数据相关联。具体目标6.为未来招募RADCO参与者 脑捐献，确保尸检顺利进行，并将临床数据与解剖、病理和 由P&B神经病理学工作产生的分子数据。这些数据将通知具有弹性和抵抗力的 在项目1中描绘的表型。脑区特定组织将被提供用于RNA表达研究 项目2.