Phenotyping and Biospecimen Core

表型分析和生物样本核心

• 批准号: 10276393
• 负责人: Stacy Andersen
• 金额: $ 149.07万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10276393
• 关键词: Affect; Age; Alzheimer' s Disease; Alzheimer’s disease biomarker; Amyloid beta-42; Anatomy; Area; Autopsy; Biological; Biological Assay; Blood specimen; Boston; Brain; COVID-19; Centenarian; Clinical Data; Cognitive; Consensus; Data; Data Collection; Dementia; Diagnosis; Disease Marker; Eligibility Determination; Enrollment; Ensure; Familiarity; Fasting; Funding; Future; Gene Expression; Genetic Markers; Genetic Transcription; Impaired cognition; Impairment; Investigation; Knowledge Portal; Lead; Link; Longevity; Los Angeles; Measures; Mission; Modeling; Molecular; Neurocognitive; Neuropsychological Tests; Neuropsychology; New York City; Outcome; Participant; Pathologic; Patient Recruitments; Phenotype; Plasma; RNA; Research Personnel; Resistance; Resource Sharing; Resources; Sampling; Scanning; Secure; Spouses; Statistical Data Interpretation; System; Time; Tissues; Work; base; biobank; cognitive function; cytokine; data de-identification; data management; data sharing; exome; experience; innovation; neuroimaging; neuropathology; offspring; phenotypic biomarker; phenotypic data; protective factors; recruit; resilience; success; symposium; tool; transcriptomics; virtual

The Phenotyping and Biospecimen (P&B) Core's primary mission is to leverage two NIA-funded centenarian studies by sifting through their study participants in identifying centenarian cognitive superagers, offspring and offspring spouses for enrollment in the RADCO study, extending their phenotyping with annual uniform neuropsychological testing, plasma biomarkers of Alzheimer's disease (AD), and facilitating and facilitating neuroimaging and post-mortem neuropathological studies among willing participants. The P&B Core's successful conduct of its six aims is critical to RADCO's investigation of centenarians and their offspring as models of cognitive resilience and resistance to cognitive impairment and AD. Those 6 Specific Aims are: Specific Aim 1. Establish a cognitive superagers (n=496, ages 100-110 years), offspring (n=600), and offspring spouses (n=120) sample with baseline neuropsychological assessments, other phenotypic data, blood samples, and genetic and biomarker data provided by 2 ongoing NIA-funded centenarian studies. Specific Aim 2. Perform annual Covid-19-safe virtual neurocognitive assessments and other phenotypic data collection that are uniform with the ILO study and LCCP measures. Also, to enhance accuracy of the neurocognitive assessments by performing interdisciplinary expert diagnoses consensus conferences. Specific Aim 3. Employing REDCap, manage and perform QC, and make easily but securely available all of the data collected and generated by the RADCO Cores and Projects, including the neuropsychological, neuroimaging, neuropathologic phenotype and biomarker and transcriptomic data. Specific Aim 4. To receive from the ILO+LCCP studies and then longitudinally collect blood samples (centenarians annually, offspring and offspring spouses every other year) from RADCO participants for use by the two projects. To maintain samples in a biorepository as a sharable resource. Specific Aim 5. Support the RADCO Neuroimaging Core's aims by recruiting RADCO participants for local neuroimaging and linking scan data to clinical data. Specific Aim 6. Recruit RADCO participants for future brain donation, ensure that autopsies proceed smoothly, and link clinical data to anatomic, pathologic and molecular data generated by the P&B neuropathology efforts. These data will inform the resilient and resistant phenotypes delineated in Project 1. Brain area-specific tissues will be provided for RNA expression studies in Project 2.

表型和生物循环（P＆B）Core的主要任务是利用两名NIA资助的百年纪念 通过筛选其研究参与者来识别一百年的认知超级词，后代和 后代配偶参加RADCO研究，以每年均匀的方式扩展其表型 神经心理学测试，阿尔茨海默氏病（AD）的血浆生物标志物以及促进和促进 愿意参与者之间的神经影像学和验尸神经病理学研究。 P＆B核心的 其六个目标的成功行为对于Radco对百岁老人及其后代的调查至关重要 认知韧性和对认知障碍和AD的抵抗力的模型。这6个具体目标是： 具体目标1。建立认知超级词（n = 496，年龄100-110岁），后代（n = 600）和后代 配偶（n = 120）样本，具有基线神经心理学评估，其他表型数据，血液样本， 以及2个正在进行的NIA资助的百年研究提供的遗传和生物标志物数据。特定目标2。执行 年度COVID-19-SAFE虚拟神经认知评估和其他表型数据收集 通过ILO研究和LCCP测量。此外，通过提高神经认知评估的准确性 进行跨学科专家诊断共识会议。特定目标3。采用redcap， 管理和执行QC，并易于可牢固可牢固地可用 RADCO核心和项目，包括神经心理学，神经影像学，神经病理表型和 生物标志物和转录组数据。特定目的4。从ILO+LCCP研究中接收，然后 纵向收集血液样本（一年 来自RADCO参与者，供两个项目使用。将样品维持在生物座位上作为可共享的 资源。特定目的5。通过招募Radco参与者的参与者来支持RADCO神经影像学的目标 局部神经影像学并将扫描数据与临床数据联系起来。具体目标6。招募Radco参与者未来 大脑捐赠，确保尸检顺利进行，并将临床数据与解剖学，病理和 P＆B神经病理学工作产生的分子数据。这些数据将告知弹性和抗性 在项目1中描述的表型。将为RNA表达研究提供大脑区域特异性组织 项目2。