Phenotyping and Biospecimen Core

表型分析和生物样本（P&B）核心的主要使命是利用两个国家免疫局资助的百岁老人 研究通过筛选他们的研究参与者，以确定百岁老人的认知超级老人，后代和 后代配偶参加RADCO研究，用年度制服扩展他们的表型 神经心理学测试，阿尔茨海默病（AD）的血浆生物标志物，以及促进和促进 在自愿参与者中进行神经影像学和死后神经病理学研究。P&B核心 成功实现其六个目标对于RADCO对百岁老人及其后代的调查至关重要， 认知恢复力和抗认知障碍和AD的模型。这六个具体目标是： 具体目标1。建立认知超级老人（n=496，年龄100-110岁），后代（n=600），和后代 配偶（n=120）样本，具有基线神经心理学评估、其他表型数据、血液样本， 和遗传和生物标志物数据提供了2个正在进行的国家情报局资助的百岁老人研究。具体目标2。执行 统一的年度Covid-19安全虚拟神经认知评估和其他表型数据收集 劳工组织的研究报告和劳工竞争政策措施。此外，为了提高神经认知评估的准确性， 进行跨学科专家诊断共识会议。具体目标3。使用REDCap， 管理和执行质量控制，并使所有收集和生成的数据容易，但安全地提供 RADCO核心和项目，包括神经心理学、神经影像学、神经病理学表型和 生物标志物和转录组学数据。具体目标4。接受劳工组织和劳工竞争政策中心的研究报告， 纵向采集血液样本（百岁老人每年，后代和后代配偶每隔一年） 供两个项目使用。将样品保存在生物储存库中作为可共享的 resource.具体目标5.通过招募RADCO参与者来支持RADCO神经影像核心的目标， 局部神经成像和将扫描数据与临床数据相关联。具体目标6.为未来招募RADCO参与者 大脑捐赠，确保尸检顺利进行，并将临床数据与解剖，病理和 由P&B神经病理学研究所产生的分子数据。这些数据将告知有弹性和耐药性的 项目1中描述的表型。将提供脑区域特异性组织用于RNA表达研究， 项目2.

The Phenotyping and Biospecimen (P&B) Core's primary mission is to leverage two NIA-funded centenarian studies by sifting through their study participants in identifying centenarian cognitive superagers, offspring and offspring spouses for enrollment in the RADCO study, extending their phenotyping with annual uniform neuropsychological testing, plasma biomarkers of Alzheimer's disease (AD), and facilitating and facilitating neuroimaging and post-mortem neuropathological studies among willing participants. The P&B Core's successful conduct of its six aims is critical to RADCO's investigation of centenarians and their offspring as models of cognitive resilience and resistance to cognitive impairment and AD. Those 6 Specific Aims are: Specific Aim 1. Establish a cognitive superagers (n=496, ages 100-110 years), offspring (n=600), and offspring spouses (n=120) sample with baseline neuropsychological assessments, other phenotypic data, blood samples, and genetic and biomarker data provided by 2 ongoing NIA-funded centenarian studies. Specific Aim 2. Perform annual Covid-19-safe virtual neurocognitive assessments and other phenotypic data collection that are uniform with the ILO study and LCCP measures. Also, to enhance accuracy of the neurocognitive assessments by performing interdisciplinary expert diagnoses consensus conferences. Specific Aim 3. Employing REDCap, manage and perform QC, and make easily but securely available all of the data collected and generated by the RADCO Cores and Projects, including the neuropsychological, neuroimaging, neuropathologic phenotype and biomarker and transcriptomic data. Specific Aim 4. To receive from the ILO+LCCP studies and then longitudinally collect blood samples (centenarians annually, offspring and offspring spouses every other year) from RADCO participants for use by the two projects. To maintain samples in a biorepository as a sharable resource. Specific Aim 5. Support the RADCO Neuroimaging Core's aims by recruiting RADCO participants for local neuroimaging and linking scan data to clinical data. Specific Aim 6. Recruit RADCO participants for future brain donation, ensure that autopsies proceed smoothly, and link clinical data to anatomic, pathologic and molecular data generated by the P&B neuropathology efforts. These data will inform the resilient and resistant phenotypes delineated in Project 1. Brain area-specific tissues will be provided for RNA expression studies in Project 2.