TR&D4: Integrated pipeline for data analysis
TR&D4: Integrated pipeline for data analysis
批准号:
10194536
负责人:
ARTHUR G PALMER
金额:
$13.86万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-06-01 至 2022-06-30
关键词:
AnisotropyBackBiologicalChemicalsCollaborationsCommunitiesComplexComputer softwareComputersDataData AnalysesDevelopmentDiffusionEnsureExperimental DesignsFeedbackGenerationsInvestigationKineticsKnowledgeLaboratoriesLeadMethodsModernizationMolecular ConformationNMR SpectroscopyOutcomePhysiologic pulseProcessProtocols documentationRelaxationResearch PersonnelRotationSchemeScientistServicesSiteSpecialistSpeedStatistical Data InterpretationTechniquesTimeValidationWritingcomputer programdata acquisitiondata analysis pipelinedata pipelineexperienceexperimental studyimprovedmacromoleculemodel buildingmolecular dynamicsnovelphysical processprogramssoftware developmentsolid statesolid state nuclear magnetic resonancetechnology research and developmentuser friendly software
中文摘要
TR&D4-用于数据分析的集成管道
摘要
计算机程序对于现代核磁共振波谱的实践是必不可少的,因为
数据和必要的数值分析的复杂性是不能不处理的
高效、高速软件的应用。这种情况,适用于所有生物
核磁共振波谱在生物构象动力学的应用中尤为关键
大分子,因为潜在的物理过程是高度复杂的,核磁共振数据
即使在最好的情况下,也不能完全捕捉到这种复杂性。在这种不确定的情况下
情况、仔细的数据量化、模型建立、统计分析和交叉验证
对于产生稳健的结果是必不可少的。现有的软件用于分析自旋弛豫和其他
这种研究的核磁共振数据很大程度上是由核磁共振专家为专家用户编写的
技术(但不一定是专业的计算机科学家),很大程度上是零碎的。对于有效的
该中心的实验技术研究和开发成果的发布
通过核磁共振波谱(COMD/核磁共振)向更广泛的科学界介绍大分子动力学,
现代、集成、用户友好的软件程序和数据分析管道是必不可少的。Tr&d4
将在反馈周期中与其他研发和DBP组件一起开发必要的软件,
建立在这项研究与开发的首席调查人员的开创性努力基础上
英文摘要
TR&D4 - Integrated pipeline for data analysis
Summary
Computer programs are essential to the practice of modern NMR spectroscopy, because the quantity
of data and the sophistication of the requisite numerical analyses simply cannot be treated without
application of efficient and high-speed software. This situation, which applies across all of biological
NMR spectroscopy, is particularly critical in applications to conformational dynamics of biological
macromolecules because the underlying physical processes are highly complex and the NMR data
under the best of circumstances cannot fully capture such complexities. In such an under-determined
situation, careful data quantification, model-building, statistical analysis, and cross-validation are
essential to generation of robust results. Existing software for analysis of spin relaxation and other
NMR data for such investigations largely has been written for expert users by experts in the NMR
techniques (but not necessarily expert computer scientists) and is largely piecemeal. For effective
promulgation of the experimental technological research and developments at the Center on
Macromolecular Dynamics by NMR Spectroscopy (CoMD/NMR) to the broader scientific community,
modern, integrated, user-friendly software programs and data analysis pipelines are essential. TR&D4
will develop the necessary software in a feedback cycle with the other TR&D and DBP components,
building on the pioneering efforts of the lead investigators for this TR&D.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Acquisition of an 800 MHz NMR Spectrometer Console and Probes
-
批准号:10632877
-
项目类别:
-
资助金额:$199.57万
-
财政年份:2023
-
负责人:ARTHUR G PALMER
-
依托单位:
RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)
-
批准号:10654062
-
项目类别:
-
资助金额:$157.05万
-
财政年份:2022
-
负责人:ARTHUR G PALMER
-
依托单位:
RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)
-
批准号:10412493
-
项目类别:
-
资助金额:$184.63万
-
财政年份:2022
-
负责人:ARTHUR G PALMER
-
依托单位:
Acquisition of a 900 MHz NMR Spectrometer Console and Probes
-
批准号:10176998
-
项目类别:
-
资助金额:$173.22万
-
财政年份:2021
-
负责人:ARTHUR G PALMER
-
依托单位:
Macromolecular dynamics and conformational changes in biological function
-
批准号:10546431
-
项目类别:
-
资助金额:$55.91万
-
财政年份:2019
-
负责人:ARTHUR G PALMER
-
依托单位:
Macromolecular dynamics and conformational changes in biological function
-
批准号:10318591
-
项目类别:
-
资助金额:$55.91万
-
财政年份:2019
-
负责人:ARTHUR G PALMER
-
依托单位:
TR&D1: Experimental design in solution NMR spectroscopy
-
批准号:10194533
-
项目类别:
-
资助金额:$13.86万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
TR&D3: Experimental design in solid-state NMR spectroscopy
-
批准号:10194535
-
项目类别:
-
资助金额:$13.86万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
Center on Macromolecular Dynamics by NMR Spectroscopy
-
批准号:10400388
-
项目类别:
-
资助金额:$47.54万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
Center on Macromolecular Dynamics by NMR Spectroscopy
-
批准号:10194529
-
项目类别:
-
资助金额:$124.78万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
Core 1:Training
-
批准号:10194530
-
项目类别:
-
资助金额:$13.86万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
Core 2: Dissemination
-
批准号:10194531
-
项目类别:
-
资助金额:$13.86万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
475 MHz NMR Spectrometer
-
批准号:9274390
-
项目类别:
-
资助金额:$92.5万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
Core 3: Administration
-
批准号:10194532
-
项目类别:
-
资助金额:$13.86万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
Collaboration and Service
-
批准号:10194538
-
项目类别:
-
资助金额:$13.86万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
TR&D2: Field-cycling relaxometry
-
批准号:10194534
-
项目类别:
-
资助金额:$13.86万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
Driving Biomedical Projects (DBPs)
-
批准号:10194537
-
项目类别:
-
资助金额:$13.86万
-
财政年份:2017
-
负责人:ARTHUR G PALMER
-
依托单位:
Acquisition of 700 MHz NMR Spectrometer
-
批准号:8734617
-
项目类别:
-
资助金额:$111.79万
-
财政年份:2015
-
负责人:ARTHUR G PALMER
-
依托单位:
Upgrade of 800 MHz Spectrometer
-
批准号:8640799
-
项目类别:
-
资助金额:$60.0万
-
财政年份:2014
-
负责人:ARTHUR G PALMER
-
依托单位:
International Council on Magnetic Resonance in Biological Systems (ICMRBS) XXVI C
-
批准号:8785790
-
项目类别:
-
资助金额:$0.5万
-
财政年份:2014
-
负责人:ARTHUR G PALMER
-
依托单位:
国内基金
海外基金
患者依从性与脑卒中后跌倒风险相关性及“Teach-Back ”护理干预效应研究
-
批准号:2026JJ81464
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:叶婷
-
依托单位:
基于Teach-back药学科普模式的慢阻肺患者吸入用药依从性及疗效研究
-
批准号:2024KP61
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2024
-
负责人:余丹
-
依托单位:
基于Quench-Back保护的超导螺线管磁体失超过程数值模拟研究
-
批准号:51307073
-
项目类别:青年科学基金项目
-
资助金额:25.0万元
-
批准年份:2013
-
负责人:郭兴龙
-
依托单位: