TR&D2: Field-cycling relaxometry

R&D 2-场循环弛豫测量 摘要 “核磁共振大分子动力学中心”(COMD/核磁共振)将安装 世界上第一个用于800 MHz核磁共振光谱仪的野外循环航天飞机系统将安装在新的 约克结构生物学中心。该仪器将使弛豫测量能够应用于DBP，以 显著增加了对相关光谱密度函数的了解，因此允许 更详细的大分子构象动力学研究。松弛测量法是一种 样品在高静磁场下极化，然后物理移动到低磁场的技术 磁场松弛一段时间，然后返回高场进行检测。在这里的活动 研发将包括评估可选的航天飞机设计，开发新的实验 航天飞机探测器的使用策略以及分析的迭代开发和验证 解释DBP松弛测量数据的方法。

TR&D 2 - Field-cycling relaxometry Summary The “Center on Macromolecular Dynamics by NMR Spectroscopy” (CoMD/NMR) will install the world's first field-cycling shuttle system for an 800 MHz NMR spectrometer, to be sited at the New York Structural Biology Center. This instrument will enable applications of relaxometry to DBPs, to significantly increase knowledge of the relevant spectral density functions and therefore allow much more detailed investigations of macromolecular conformational dynamics. Relaxometry is a technique in which a sample is polarized at high static magnetic field, then physically moved to low field for a relaxation period, and subsequently returned to high field for detection. Activities in this TR&D will include evaluation of alternative shuttle designs, development of novel experimental strategies for use of the shuttle probe, and iterative development and validation of analysis approaches to interpret relaxometric data for the DBPs.