TR&D2: Field-cycling relaxometry

TR&D 2 -场循环弛豫法 总结 “核磁共振光谱法大分子动力学中心”（CoMD/NMR）将安装 世界上第一个用于800 MHz NMR光谱仪的场循环穿梭系统，将位于纽约 约克结构生物学中心。该仪器将使弛豫法应用于DBP， 显著增加了相关谱密度函数的知识，因此允许 更详细的研究大分子构象动力学。松弛法是一种 在高静磁场下极化样品，然后物理移动到低静磁场的技术 场，随后返回到高场进行检测。这方面的活动 TR&D将包括评估替代航天飞机设计，开发新的实验 穿梭探针的使用策略，以及分析的迭代开发和验证 解释DBP弛豫数据的方法。

TR&D 2 - Field-cycling relaxometry Summary The “Center on Macromolecular Dynamics by NMR Spectroscopy” (CoMD/NMR) will install the world's first field-cycling shuttle system for an 800 MHz NMR spectrometer, to be sited at the New York Structural Biology Center. This instrument will enable applications of relaxometry to DBPs, to significantly increase knowledge of the relevant spectral density functions and therefore allow much more detailed investigations of macromolecular conformational dynamics. Relaxometry is a technique in which a sample is polarized at high static magnetic field, then physically moved to low field for a relaxation period, and subsequently returned to high field for detection. Activities in this TR&D will include evaluation of alternative shuttle designs, development of novel experimental strategies for use of the shuttle probe, and iterative development and validation of analysis approaches to interpret relaxometric data for the DBPs.