Acquisition of a 900 MHz NMR Spectrometer Console and Probes

申请资金用于购买布鲁克Biospin NMR AVANCE控制台和待安装的探头 在现有的Bruker Biospin 900 MHz NMR磁体系统上。现有的NMR控制台和探头 使用年限超过14年，并已达到布鲁克指定的使用寿命终点 Biospin所要求的仪器提供了增强的灵敏度和能力， NMR实验，包括非均匀采样、复杂波形生成和1H魔- 角旋转固态NMR光谱。所要求的仪器对过度- 纽约结构生物学中心（NYSBC）是一个由九个研究机构组成的联盟， 纽约州的研究机构，以支持NIH资助的主要研究的特定目标， 和光谱仪的小用户对900 MHz核磁共振波谱仪的研究 范围从生物分子结构/功能的基础研究，到机制的阐明， 发病机制，发现新的先导化合物的药物应用。的 所要求的仪器将大大提高900兆赫核磁共振波谱仪的能力 进行这项研究。

Funding is requested to obtain a Bruker Biospin NMR AVANCE Console and Probes to be installed on an existing Bruker Biospin 900 MHz NMR magnet system. The existing NMR console and probes are more than 14 years old and have reached the end of service lifetime, as designated by Bruker Biospin. The requested instrumentation provides enhanced sensitivity and capabilities for modern NMR experiments, including non-uniform sampling, complex waveform generation, and 1H magic- angle spinning solid-state NMR spectroscopy. The requested instrumentation is essential to the over- riding purpose of the New York Structural Biology Center (NYSBC), a consortium of nine research institutions in New York State, to support the particular aims of the NIH-funded research of the major and minor users of the spectrometer. Research conducted on the 900 MHz NMR Spectrometer ranges from fundamental studies of structure/function of biomolecules, to elucidation of mechanisms of pathogenesis, to discovery of novel lead compounds to pharmaceutical applications. The requested instrumentation will dramatically enhance the capacity of the 900 MHz NMR spectrometer to conduct this research.