Upgrade of 800 MHz Spectrometer

申请资金用于升级一台已有十多年历史的800 MHz NMR光谱仪， Biospin AVANCE III HD NMR控制台和相关的BMPC-II和CryoPlatform装置， 过时且越来越不可靠。要求的设备将安装在现有的布鲁克 Spectrosspin主动屏蔽18.8 T磁体，并将利用现有z梯度TCI CryoProbe。 要求对800兆赫核磁共振波谱仪进行升级，这对实现压倒一切的目标至关重要 纽约结构生物学中心（NYSBC）是一个由纽约九个研究机构组成的联盟， 约克州，以支持NIH资助的研究的主要和次要用户的特定目标， 光谱仪在800 MHz仪器上进行的研究从基础研究 生物分子的结构/功能，阐明发病机制，发现 新的先导化合物用于药物应用。请求的每个组件 设备在性能方面提供了显著的改进， 提高800兆赫核磁共振波谱仪进行这项研究的能力。

Funding is requested to upgrade a more than ten-year-old 800 MHz NMR spectrometer with a Bruker Biospin AVANCE III HD NMR Console and associated BMPC-II and CryoPlatform units that are now obsolete and increasingly unreliable. The requested equipment will be installed on an existing Bruker Spectrospin actively shielded 18.8 T magnet and will utilize the existing z-gradient TCI CryoProbe. The requested upgrades of the 800 MHz NMR spectrometer are essential to the over-riding purpose of the New York Structural Biology Center (NYSBC), a consortium of nine research institutions in New York State, to support the particular aims of the NIH-funded research of the major and minor users of the spectrometer. Research conducted on the 800 MHz instrument ranges from fundamental studies of structure/function of biomolecules, to elucidation of mechanisms of pathogenesis, to discovery of novel lead compounds to pharmaceutical applications. Each of the components of the requested equipment provides significant improvements in performance that in their entirety will dramatically enhance the capacity of the 800 MHz NMR spectrometer to conduct this research.