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TR&D3: Experimental design in solid-state NMR spectroscopy

TR&D3: Experimental design in solid-state NMR spectroscopy
TR
批准号：
10194535
负责人：
ARTHUR G PALMER
金额：
$13.86万
依托单位：
NEW YORK STRUCTURAL BIOLOGY CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
已结题
起止时间：
2017-06-01 至 2022-06-30
来源：
https://reporter.nih.gov/project-details/10194535
关键词：
AnisotropyBiologicalBiopolymersCharacteristicsChemicalsComplexCryoelectron MicroscopyCrystallizationDataData AnalysesDetectionDevelopmentDiseaseElementsEquilibriumExperimental DesignsFree EnergyFreezingInvestigationJointsMagicMeasurementMedicineMembraneMethodologyMethodsMolecular ConformationMotionNMR SpectroscopyNatureNuclearPopulationProceduresProcessProteinsProtocols documentationRelaxationResearch PersonnelResolutionRoleSamplingSignal TransductionSignaling ProteinSiteSolubilitySolventsSpectrum AnalysisStructureSystemTechnologyTemperatureThermodynamicsTorsionX ray diffraction analysisbasecold temperaturecollegecomputer studiesconformational conversionexpectationexperimental studyhigh dimensionalityinsightinstrumentationmacromoleculemillisecondmimeticsrestraintsolid statesolid state nuclear magnetic resonancestudy population

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英文摘要
TR&D3 - Experimental design in solid-state NMR spectroscopy Summary High resolution MAS-based SSNMR can be used to obtain detailed site-specific information on the structure, thermodynamics and dynamics of biopolymers, and is applicable to a broad range of systems that in native form are inaccessible to other methods. Solution and solid-state NMR are complementary to each other, and to X-ray diffraction and cryo electron microscopy, in terms of many methodological aspects and in terms of biological opportunities. TR&D3 at CoMD/NMR will utilize the strong expertise and instrumentation at NYSBC to develop technology for investigation of conformational dynamics of biological macromolecules by solid-state NMR spectroscopy.
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Acquisition of an 800 MHz NMR Spectrometer Console and Probes
RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)
RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)
Acquisition of a 900 MHz NMR Spectrometer Console and Probes
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