Striatal mechanisms for e-cigarette reinforcement by flavorants
香料增强电子烟的纹状体机制
基本信息
- 批准号:10197866
- 负责人:
- 金额:$ 58.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-30 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescenceAdolescentAdultAffectAgeAreaAutomobile DrivingBehaviorBehavioralBiochemicalBrainCandyCenters for Disease Control and Prevention (U.S.)Cessation of lifeChemical ActionsChronicCigaretteClinical ResearchConsumptionCorpus striatum structureCuesDataDependenceDevicesDiseaseDopamine D2 ReceptorDopamine ReceptorDoseElectronic cigaretteElectrophysiology (science)ExclusionExposure toFlavoringFosteringFriendsFruitFutureGenus MenthaGoalsHigh School StudentHumanJUULMeasuresMentha spicataMentholMinorMusNeuronsNicotineNicotine DependenceNicotinic ReceptorsNucleus AccumbensOdorsOlfactory tubercleOutputPharmacologic ActionsPlayPoliciesPropertyPsychological reinforcementRewardsRoleSalesSelf AdministrationSensorySliceSmell PerceptionStimulusStrawberriesSynapsesSynaptic plasticityTeenagersTestingTime StudyVendorVentral StriatumVentral Tegmental Areabasecholinergic neuroncombustible cigaretteconditioned place preferencedopaminergic neurondrug of abusee-cigarette aerosolselectronic cigarette useelectronic liquidexperienceexperimental studyinsightmesolimbic systemnerve supplyneuronal excitabilityneurophysiologynicotine exposurenicotine rewardnicotine seeking behaviornicotine vaporolfactory nucleioptogeneticspreclinical studypreferencepsychostimulantpublic health relevancereinforcerrelating to nervous systemresponsereward circuitryreward processingsensory inputsmoking cessationsoft drinktobacco controltobacco productsvapingvaporyoung adult
项目摘要
E-cigarettes are increasingly used by teenagers, who are particularly vulnerable to the addictive
properties of nicotine. With the exclusion of menthol, the use of flavor additives has been banned from
traditional cigarettes, while e-cigarettes (e-cigs) are marketed in over 7,000 different flavors. We
hypothesize that flavorants enhance nicotine reward through sensory and/or natural reward
mechanisms. As a consequence, flavored e-cigs may promote nicotine experimentation, dependence,
and eventually, the use of regular cigarettes. Despite the fact that the FDA has recently regulated the
sales of flavored e-cigs to minors, no flavor ban has been implemented, and adolescents could still
obtain flavored e-cig products through friends or unscrupulous sellers. Furthermore, understanding how
flavors influence e-cig use is important for the implementation of regulatory rules that can reduce
potential disease and death deriving from the consumption of this increasingly popular tobacco product.
The overall goal of this application is to compare the rewarding and reinforcing properties of
flavored vs. non-flavored e-cigs in adolescent and adult mice, and identify the neural substrates
responsible for the enhancing effects of flavorants. Our hypothesis is that flavored e-cigs are more
rewarding than non-flavored e-cigs and that flavor additives promote and sustain nicotine seeking in
adolescents due to the combined influence of flavorants and nicotine on the ventral striatum. The first
goal is to determine whether flavorants enhance adolescent nicotine reward and promote nicotine self-
administration, and compare their effects in adult mice. The second goal is to understand how e-cig
flavorants are encoded in the ventral striatum during acquisition of e-cigarette vapor preference and
self-administration. The third goal is to determine whether exposure to e-cig flavorants alters synaptic
plasticity in the ventral striatum and whether it modifies cellular responses to nicotine. Our experiments
will combine behavioral approaches with tetrode recordings during behavior and brain slice
electrophysiology to determine how e-cigarette nicotine vapor affects reward-associated brain areas,
and whether flavorants (e.g. fruit or mint) have additive or synergistic effects.
越来越多的青少年使用电子烟,他们特别容易上瘾
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mariella De Biasi其他文献
Mariella De Biasi的其他文献
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{{ truncateString('Mariella De Biasi', 18)}}的其他基金
Educating Physician Scientists in Psychiatry (EPSP): Firing up the next generation of translational and clinical neuroscientists
精神病学医师科学家教育 (EPSP):培养下一代转化和临床神经科学家
- 批准号:
10353376 - 财政年份:2019
- 资助金额:
$ 58.13万 - 项目类别:
Striatal mechanisms for e-cigarette reinforcement by flavorants
香料增强电子烟的纹状体机制
- 批准号:
10452636 - 财政年份:2019
- 资助金额:
$ 58.13万 - 项目类别:
Striatal mechanisms for e-cigarette reinforcement by flavorants
香料增强电子烟的纹状体机制
- 批准号:
10660974 - 财政年份:2019
- 资助金额:
$ 58.13万 - 项目类别:
Striatal mechanisms for e-cigarette reinforcement by flavorants
香料增强电子烟的纹状体机制
- 批准号:
10017928 - 财政年份:2019
- 资助金额:
$ 58.13万 - 项目类别:
Striatal mechanisms for e-cigarette reinforcement by flavorants
香料增强电子烟的纹状体机制
- 批准号:
10874294 - 财政年份:2019
- 资助金额:
$ 58.13万 - 项目类别:
Striatal mechanisms for e-cigarette reinforcement by flavorants
香料增强电子烟的纹状体机制
- 批准号:
10656610 - 财政年份:2019
- 资助金额:
$ 58.13万 - 项目类别:
Educating Physician Scientists in Psychiatry (EPSP): Firing up the next generation of translational and clinical neuroscientists
精神病学医师科学家教育 (EPSP):培养下一代转化和临床神经科学家
- 批准号:
10094259 - 财政年份:2019
- 资助金额:
$ 58.13万 - 项目类别:
Educating Physician Scientists in Psychiatry (EPSP): Firing up the next generation of translational and clinical neuroscientists
精神病学医师科学家教育 (EPSP):培养下一代转化和临床神经科学家
- 批准号:
10569533 - 财政年份:2019
- 资助金额:
$ 58.13万 - 项目类别:
Translational study on CHRNA5 variation and alcohol reward mechanisms
CHRNA5变异与酒精奖励机制的转化研究
- 批准号:
10413132 - 财政年份:2018
- 资助金额:
$ 58.13万 - 项目类别:
Flavored e-cigarette use in adolescents: Behavioral, cellular, and epigenetic mechanisms
青少年使用调味电子烟:行为、细胞和表观遗传机制
- 批准号:
9521691 - 财政年份:2018
- 资助金额:
$ 58.13万 - 项目类别:
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