A novel flat-panel detector for advanced on-board radiation therapy imaging

用于先进机载放射治疗成像的新型平板探测器

• 批准号: 10202493
• 负责人: Ross I. Berbeco
• 金额: $ 59.71万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10202493
• 关键词: 3-Dimensional; Acceleration; American College of Radiology; Clinic; Clinical; Dana-Farber Cancer Institute; Data; Development; Devices; Dose; Electronics; Future; Goals; Grant; Head and neck structure; High Performance Computing; Hour; Image; Imaging Device; Implant; Infrastructure; Knowledge; Linear Accelerator Radiotherapy Systems; Lung; Magnetic Resonance Imaging; Medical; Metals; Methods; Monte Carlo Method; Morphologic artifacts; Parents; Patients; Penetration; Performance; Physics; Procedures; Productivity; Prostate; Publishing; Radiation Oncology; Radiation therapy; Research; Roentgen Rays; Scheme; System; Testing; Time; Translating; United States National Institutes of Health; Vertebral column; Weight; base; clinical application; clinical translation; cost; design; detector; experience; image reconstruction; imager; improved; innovation; new technology; novel; reconstruction; research clinical testing; simulation; soft tissue; tool

Project Summary Despite recent technological advances, on-treatment imaging for radiotherapy procedures is still a significant challenge for tens of thousands of patients. On-board MRI or kV x-ray systems are either prohibitively expensive, provide incomplete information, or are incompatible with implanted metal devices. According to the American College of Radiology, megavoltage (MV) volumetric imaging has a clear advantage in terms of metal artifact reduction, direct dose calculation and real-time adaptive radiotherapy, but is challenged by low contrast and high imaging doses. We have demonstrated that this limitation can be overcome by a novel multi-layer imager to provide high-contrast, low-dose on-treatment MV imaging. This new technology will remove metal artifacts while retaining soft-tissue contrast and enable real-time adaptive radiotherapy. We have invented and validated a Monte Carlo-based tool that enables accurate image simulation in a fraction of the time required for conventional Monte Carlo simulation – enabling efficient imager optimization to be performed. Our preliminary data with a novel low-cost scintillator and efficient layering combinations has already demonstrated low- dose/high-quality MV-CBCT, rivaling conventional kV-CBCT, with added benefits of artifact reduction and Hounsfield unit accuracy. The Specific Aims of the current proposal will leverage our combined experience and previous results to produce an optimized imager suitable for widespread clinical use. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

项目概要 尽管最近的技术取得了进步，放射治疗过程中的治疗成像仍然是一个重要的领域。 为数以万计的患者带来挑战。机载 MRI 或 kV X 射线系统要么令人望而却步 价格昂贵、提供的信息不完整或与植入的金属设备不兼容。根据 美国放射学院兆伏（MV）体积成像在金属方面具有明显优势 伪影减少、直接剂量计算和实时自适应放疗，但受到低对比度的挑战 和高成像剂量。我们已经证明，这种限制可以通过一种新颖的多层结构来克服 成像仪提供高对比度、低剂量的治疗中 MV 成像。这项新技术将去除金属 伪影，同时保留软组织对比度并实现实时自适应放射治疗。我们发明并 验证了基于蒙特卡罗的工具，该工具可以在所需时间的一小部分内实现精确的图像模拟 传统的蒙特卡罗模拟 – 能够执行高效的成像器优化。我们的初步 具有新型低成本闪烁体和高效分层组合的数据已经证明了低 剂量/高质量 MV-CBCT，可与传统 kV-CBCT 相媲美，并具有减少伪影和 亨斯菲尔德单位精度。当前提案的具体目标将利用我们的综合经验和 先前的结果可产生适合广泛临床使用的优化成像仪。 PHS 398/2590（修订版 06/09） 页面延续 格式页面