Gold nanoparticles as vascular disruptig agents in radiation therapy of NSCLC

金纳米粒子作为血管破坏剂在非小细胞肺癌放射治疗中的应用

基本信息

  • 批准号:
    9026582
  • 负责人:
  • 金额:
    $ 21.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-03-03 至 2018-02-28
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Recent developments in anti-angiogenic and vascular-disrupting therapies have shown the great potential of tumor vasculature as a therapeutic target for cancer medicine. We have an original idea for using targeted gold nanoparticles (GNP) as vascular disruptive agents (VDA) in conjunction with clinical megavoltage photon beams. Unlike competing proposals, we recognize that gold nanoparticles tend to accumulate in, and can even be targeted for, tumor blood vessels and that these structures may be more important for anti-cancer therapy than clonogenic cell death alone. Due to the short distance traveled by x-ray induced photoelectrons, the endothelial cells of the tumor will receive a sizable boost in dose, even for clinical megavoltage (MV) photon irradiation. Our preliminary results include: development, characterization and testing of a novel 4th generation nano-platform; theoretical and experimental evidence of dose enhancement in a MV clinical radiation therapy beam-line; and imaging studies of preferential tumor uptake. The proposed study will determine the optimal time window for radiation therapy after GNP administration and measure the therapy benefit in a preclinical lung cancer model. Our innovative therapy concept is highly compatible with current clinical practice and could offer a substantial clinical benefit with minimal patient risk.


项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Key clinical beam parameters for nanoparticle-mediated radiation dose amplification.
  • DOI:
    10.1038/srep34040
  • 发表时间:
    2016-09-23
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Detappe A;Kunjachan S;Drané P;Kotb S;Myronakis M;Biancur DE;Ireland T;Wagar M;Lux F;Tillement O;Berbeco R
  • 通讯作者:
    Berbeco R
Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance-Computed Tomography Image Guided Radiation Therapy.
  • DOI:
    10.1021/acs.nanolett.6b05055
  • 发表时间:
    2017-03-08
  • 期刊:
  • 影响因子:
    10.8
  • 作者:
    Detappe A;Thomas E;Tibbitt MW;Kunjachan S;Zavidij O;Parnandi N;Reznichenko E;Lux F;Tillement O;Berbeco R
  • 通讯作者:
    Berbeco R
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Ross I. Berbeco其他文献

RETRACTED ARTICLE: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery
撤回文章:放疗对肿瘤血管的选择性启动增强纳米药物递送
  • DOI:
    10.1038/s41598-019-50538-w
  • 发表时间:
    2019-11-01
  • 期刊:
  • 影响因子:
    3.900
  • 作者:
    Sijumon Kunjachan;Shady Kotb;Robert Pola;Michal Pechar;Rajiv Kumar;Bijay Singh;Felix Gremse;Reza Taleeli;Florian Trichard;Vincent Motto-Ros;Lucie Sancey;Alexandre Detappe;Sayeda Yasmin-Karim;Andrea Protti;Ilanchezhian Shanmugam;Thomas Ireland;Tomas Etrych;Srinivas Sridhar;Olivier Tillement;Mike Makrigiorgos;Ross I. Berbeco
  • 通讯作者:
    Ross I. Berbeco

Ross I. Berbeco的其他文献

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{{ truncateString('Ross I. Berbeco', 18)}}的其他基金

Cross-Training Core (ROBIN-NEST)
交叉训练核心 (ROBIN-NEST)
  • 批准号:
    10712297
  • 财政年份:
    2023
  • 资助金额:
    $ 21.63万
  • 项目类别:
Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy
用于 MR 引导放射治疗的铋钆纳米颗粒的转化
  • 批准号:
    10359706
  • 财政年份:
    2020
  • 资助金额:
    $ 21.63万
  • 项目类别:
Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy
用于 MR 引导放射治疗的铋钆纳米颗粒的转化
  • 批准号:
    10626724
  • 财政年份:
    2020
  • 资助金额:
    $ 21.63万
  • 项目类别:
Gold nanoparticles as vascular disruptig agents in radiation therapy of NSCLC
金纳米粒子作为血管破坏剂在非小细胞肺癌放射治疗中的应用
  • 批准号:
    8893262
  • 财政年份:
    2015
  • 资助金额:
    $ 21.63万
  • 项目类别:
A novel flat-panel detector for advanced on-board radiation therapy imaging
用于先进机载放射治疗成像的新型平板探测器
  • 批准号:
    10652362
  • 财政年份:
    2014
  • 资助金额:
    $ 21.63万
  • 项目类别:
A high efficiency imager for real-time lung cancer monitoring during radiotherapy
用于放射治疗过程中实时肺癌监测的高效成像仪
  • 批准号:
    9318469
  • 财政年份:
    2014
  • 资助金额:
    $ 21.63万
  • 项目类别:
A novel flat-panel detector for advanced on-board radiation therapy imaging
用于先进机载放射治疗成像的新型平板探测器
  • 批准号:
    10202493
  • 财政年份:
    2014
  • 资助金额:
    $ 21.63万
  • 项目类别:
A high efficiency imager for real-time lung cancer monitoring during radiotherapy
用于放射治疗过程中实时肺癌监测的高效成像仪
  • 批准号:
    9358862
  • 财政年份:
    2014
  • 资助金额:
    $ 21.63万
  • 项目类别:
A novel flat-panel detector for advanced on-board radiation therapy imaging
用于先进机载放射治疗成像的新型平板探测器
  • 批准号:
    10428566
  • 财政年份:
    2014
  • 资助金额:
    $ 21.63万
  • 项目类别:
A high efficiency imager for real-time lung cancer monitoring during radiotherapy
用于放射治疗过程中实时肺癌监测的高效成像仪
  • 批准号:
    8917151
  • 财政年份:
    2014
  • 资助金额:
    $ 21.63万
  • 项目类别:

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