Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy

用于 MR 引导放射治疗的铋钆纳米颗粒的转化

• 批准号: 10359706
• 负责人: Ross I. Berbeco
• 金额: $ 59.5万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10359706
• 关键词: A549; Aorta; Biodistribution; Biological; Bismuth; Blood Vessels; Brain; Cancer Patient; Chemistry; Clinic; Clinical; Collaborations; Contrast Media; Dana-Farber Cancer Institute; Data; Disease; Dose; Dose-Limiting; Drug Kinetics; Environment; Esophagus; Exhibits; Formulation; Gadolinium; Goals; Histopathology; Image; Lead; Letters; Lung; Lung Neoplasms; Magnetic Resonance Imaging; Malignant neoplasm of lung; Methods; Modeling; Non-Small-Cell Lung Carcinoma; Normal tissue morphology; Operative Surgical Procedures; Organ; Paper; Patient risk; Patients; Phase I Clinical Trials; Phase II Clinical Trials; Process; Property; Radiation; Radiation Oncology; Radiation Physics; Radiation therapy; Research Personnel; Rodent; Safety; Schedule; Solid Neoplasm; Structure; Technology; Testing; Therapeutic; Therapy Evaluation; Toxic effect; Translating; Translations; Tumor Tissue; Work; base; biomaterial compatibility; cancer cell; cancer therapy; clinical practice; clinical translation; clinically relevant; contrast enhanced; contrast imaging; design; effective therapy; improved; in vivo; industry partner; innovation; irradiation; lung lesion; nano; nanoparticle; nonhuman primate; novel; particle; patient population; phase I trial; pre-clinical; prototype; scale up; success; translational model; trend; tumor; tumor growth; uptake

Project Summary Recent preclinical and clinical results have demonstrated the safety and efficacy of nanoparticle-amplified radiation therapy. In parallel, MR-guided radiation therapy is an emerging paradigm that would benefit from specific contrast agents. This Academic- Industrial Partnership will leverage these current trends by designing, developing and rigorously testing a novel nanoparticle for MR-guided radiation therapy. Our supporting data consists of extensive physical and biological characterization of gadolinium and bismuth-gadolinium based nanoparticles, including in vivo biodistribution, imaging and therapy results in multiple tumor models. In this project, we will develop and optimize a direct high-yield synthesis process for bismuth-gadolinium nanoparticles and perform extensive toxicity and therapy evaluation in a translational model under clinical delivery schedules and conditions. Our innovative and highly translatable imaging and therapy concept is compatible with current and emerging clinical practice and could offer a substantial clinical benefit with minimal patient risk.

项目摘要 最近的临床前和临床结果已经证明了 纳米粒子放大放射治疗。同时，MR引导放射治疗是一种 新兴的范例，将受益于特定的造影剂。这个学术- 工业伙伴关系将通过设计、开发和 严格测试用于MR引导放射治疗的新型纳米颗粒。我们的支持 数据包括钆的广泛的物理和生物特性， 铋-钆基纳米颗粒，包括体内生物分布、成像和 治疗产生多种肿瘤模型。在这个项目中，我们将开发和优化一个 铋-钆纳米颗粒的直接高产率合成方法及预制体 在临床递送下的转化模型中的广泛毒性和治疗评价 时间表和条件。我们的创新和高度可翻译的成像和治疗 这一概念与当前和新兴的临床实践相兼容， 显著的临床受益，患者风险最小。