Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy
用于 MR 引导放射治疗的铋钆纳米颗粒的转化
基本信息
- 批准号:10359706
- 负责人:
- 金额:$ 59.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-03-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:A549AortaBiodistributionBiologicalBismuthBlood VesselsBrainCancer PatientChemistryClinicClinicalCollaborationsContrast MediaDana-Farber Cancer InstituteDataDiseaseDoseDose-LimitingDrug KineticsEnvironmentEsophagusExhibitsFormulationGadoliniumGoalsHistopathologyImageLeadLettersLungLung NeoplasmsMagnetic Resonance ImagingMalignant neoplasm of lungMethodsModelingNon-Small-Cell Lung CarcinomaNormal tissue morphologyOperative Surgical ProceduresOrganPaperPatient riskPatientsPhase I Clinical TrialsPhase II Clinical TrialsProcessPropertyRadiationRadiation OncologyRadiation PhysicsRadiation therapyResearch PersonnelRodentSafetyScheduleSolid NeoplasmStructureTechnologyTestingTherapeuticTherapy EvaluationToxic effectTranslatingTranslationsTumor TissueWorkbasebiomaterial compatibilitycancer cellcancer therapyclinical practiceclinical translationclinically relevantcontrast enhancedcontrast imagingdesigneffective therapyimprovedin vivoindustry partnerinnovationirradiationlung lesionnanonanoparticlenonhuman primatenovelparticlepatient populationphase I trialpre-clinicalprototypescale upsuccesstranslational modeltrendtumortumor growthuptake
项目摘要
Project Summary
Recent preclinical and clinical results have demonstrated the safety and efficacy of
nanoparticle-amplified radiation therapy. In parallel, MR-guided radiation therapy is an
emerging paradigm that would benefit from specific contrast agents. This Academic-
Industrial Partnership will leverage these current trends by designing, developing and
rigorously testing a novel nanoparticle for MR-guided radiation therapy. Our supporting
data consists of extensive physical and biological characterization of gadolinium and
bismuth-gadolinium based nanoparticles, including in vivo biodistribution, imaging and
therapy results in multiple tumor models. In this project, we will develop and optimize a
direct high-yield synthesis process for bismuth-gadolinium nanoparticles and perform
extensive toxicity and therapy evaluation in a translational model under clinical delivery
schedules and conditions. Our innovative and highly translatable imaging and therapy
concept is compatible with current and emerging clinical practice and could offer a
substantial clinical benefit with minimal patient risk.
项目摘要
最近的临床前和临床结果已经证明了
纳米粒子增强放射治疗同时,MR引导放射治疗是一种
新兴的范例,将受益于特定的造影剂。这个学术-
工业伙伴关系将通过设计、开发和
严格测试用于MR引导放射治疗的新型纳米颗粒。我们的支持
数据包括钆的广泛的物理和生物特性,
铋-钆基纳米颗粒,包括体内生物分布、成像和
治疗产生多种肿瘤模型。在这个项目中,我们将开发和优化一个
铋-钆纳米颗粒的直接高产率合成方法及预制体
在临床递送下的转化模型中的广泛毒性和治疗评价
时间表和条件。我们的创新和高度可翻译的成像和治疗
这一概念与当前和新兴的临床实践相兼容,
显著的临床受益,患者风险最小。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ross I. Berbeco其他文献
RETRACTED ARTICLE: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery
撤回文章:放疗对肿瘤血管的选择性启动增强纳米药物递送
- DOI:
10.1038/s41598-019-50538-w - 发表时间:
2019-11-01 - 期刊:
- 影响因子:3.900
- 作者:
Sijumon Kunjachan;Shady Kotb;Robert Pola;Michal Pechar;Rajiv Kumar;Bijay Singh;Felix Gremse;Reza Taleeli;Florian Trichard;Vincent Motto-Ros;Lucie Sancey;Alexandre Detappe;Sayeda Yasmin-Karim;Andrea Protti;Ilanchezhian Shanmugam;Thomas Ireland;Tomas Etrych;Srinivas Sridhar;Olivier Tillement;Mike Makrigiorgos;Ross I. Berbeco - 通讯作者:
Ross I. Berbeco
Ross I. Berbeco的其他文献
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{{ truncateString('Ross I. Berbeco', 18)}}的其他基金
Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy
用于 MR 引导放射治疗的铋钆纳米颗粒的转化
- 批准号:
10626724 - 财政年份:2020
- 资助金额:
$ 59.5万 - 项目类别:
Gold nanoparticles as vascular disruptig agents in radiation therapy of NSCLC
金纳米粒子作为血管破坏剂在非小细胞肺癌放射治疗中的应用
- 批准号:
9026582 - 财政年份:2015
- 资助金额:
$ 59.5万 - 项目类别:
Gold nanoparticles as vascular disruptig agents in radiation therapy of NSCLC
金纳米粒子作为血管破坏剂在非小细胞肺癌放射治疗中的应用
- 批准号:
8893262 - 财政年份:2015
- 资助金额:
$ 59.5万 - 项目类别:
A novel flat-panel detector for advanced on-board radiation therapy imaging
用于先进机载放射治疗成像的新型平板探测器
- 批准号:
10652362 - 财政年份:2014
- 资助金额:
$ 59.5万 - 项目类别:
A high efficiency imager for real-time lung cancer monitoring during radiotherapy
用于放射治疗过程中实时肺癌监测的高效成像仪
- 批准号:
9318469 - 财政年份:2014
- 资助金额:
$ 59.5万 - 项目类别:
A novel flat-panel detector for advanced on-board radiation therapy imaging
用于先进机载放射治疗成像的新型平板探测器
- 批准号:
10202493 - 财政年份:2014
- 资助金额:
$ 59.5万 - 项目类别:
A high efficiency imager for real-time lung cancer monitoring during radiotherapy
用于放射治疗过程中实时肺癌监测的高效成像仪
- 批准号:
9358862 - 财政年份:2014
- 资助金额:
$ 59.5万 - 项目类别:
A novel flat-panel detector for advanced on-board radiation therapy imaging
用于先进机载放射治疗成像的新型平板探测器
- 批准号:
10428566 - 财政年份:2014
- 资助金额:
$ 59.5万 - 项目类别:
A high efficiency imager for real-time lung cancer monitoring during radiotherapy
用于放射治疗过程中实时肺癌监测的高效成像仪
- 批准号:
8917151 - 财政年份:2014
- 资助金额:
$ 59.5万 - 项目类别:
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