Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy

项目摘要 最近的临床前和临床结果已经证明了 纳米粒子增强放射治疗同时，MR引导放射治疗是一种 新兴的范例，将受益于特定的造影剂。这个学术- 工业伙伴关系将通过设计、开发和 严格测试用于MR引导放射治疗的新型纳米颗粒。我们的支持 数据包括钆的广泛的物理和生物特性， 铋-钆基纳米颗粒，包括体内生物分布、成像和 治疗产生多种肿瘤模型。在这个项目中，我们将开发和优化一个 铋-钆纳米颗粒的直接高产率合成方法及预制体 在临床递送下的转化模型中的广泛毒性和治疗评价 时间表和条件。我们的创新和高度可翻译的成像和治疗 这一概念与当前和新兴的临床实践相兼容， 显著的临床受益，患者风险最小。

Project Summary Recent preclinical and clinical results have demonstrated the safety and efficacy of nanoparticle-amplified radiation therapy. In parallel, MR-guided radiation therapy is an emerging paradigm that would benefit from specific contrast agents. This Academic- Industrial Partnership will leverage these current trends by designing, developing and rigorously testing a novel nanoparticle for MR-guided radiation therapy. Our supporting data consists of extensive physical and biological characterization of gadolinium and bismuth-gadolinium based nanoparticles, including in vivo biodistribution, imaging and therapy results in multiple tumor models. In this project, we will develop and optimize a direct high-yield synthesis process for bismuth-gadolinium nanoparticles and perform extensive toxicity and therapy evaluation in a translational model under clinical delivery schedules and conditions. Our innovative and highly translatable imaging and therapy concept is compatible with current and emerging clinical practice and could offer a substantial clinical benefit with minimal patient risk.