A high efficiency imager for real-time lung cancer monitoring during radiotherapy

用于放射治疗过程中实时肺癌监测的高效成像仪

• 批准号: 8917151
• 负责人: Ross I. Berbeco
• 金额: $ 76.06万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8917151
• 关键词: Anatomy; Cancer Patient; Clinic; Clinical; Collaborations; Computer software; Dana-Farber Cancer Institute; Data; Development; Dose; Ensure; Eye; Fiber; Geometry; Goals; Health; Image; Imaging Device; Imaging Techniques; Intensity-Modulated Radiotherapy; Internet; Lung; Lung Neoplasms; Malignant neoplasm of lung; Marketing; Measurement; Medical; Methods; Modeling; Monitor; Motion; Nature; Noise; Online Systems; Patients; Radiation; Radiation therapy; Recording of previous events; Research; Research Personnel; Respiration; System; Testing; Time; Translations; Validation; Work; base; cancer imaging; clinical application; cost; design; imaging modality; improved; meetings; novel; photon-counting detector; pre-clinical; research clinical testing; research study; tool; tumor

DESCRIPTION (provided by applicant): Direct in-treatment imaging of lung tumors during radiation therapy to ensure proper radiation targeting is an unsolved challenge. We propose to overcome this obstacle using beam's-eye-view (BEV) imaging with a high efficiency imager to automatically localize lung tumors in real-time. The project goal is to design, validate and clinically deploy the new high efficiency imager. We will first determine the specifications necessary for robust BEV imaging. The design of the novel imager to meet this goal will be performed using a new Monte Carlo platform. Scintillator composition, pixelation and stacking of multiple layers will be optimized and the new imager will be validated prior to full scale deployment in a radiation therapy clinic. In addition to the immediate clinical benefits of real-tie lung tumor localization, we anticipate that this project will accelerate advanced applications like tumor tracking, delivered dose accumulation and adaptive radiation therapy. The Monte Carlo platform will also hasten the development of novel imagers for other medical applications beyond this project. Therefore the impact of the project extends far beyond the immediate clinical gain, which is in itself substantial.

描述（由申请人提供）：在放射治疗期间对肺肿瘤进行直接治疗中成像以确保适当的放射靶向是一项尚未解决的挑战。我们建议克服这一障碍，使用光束的眼睛视图（BEV）成像与高效率的成像自动定位实时肺肿瘤。该项目的目标是设计、验证和临床部署新型高效成像仪。我们将首先确定强大的BEV成像所需的规格。新的成像器的设计，以满足这一目标将使用一个新的蒙特卡罗平台。闪烁体成分、像素和多层堆叠将得到优化，新成像仪将在放射治疗诊所全面部署之前得到验证。除了实时肺部肿瘤定位的直接临床益处外，我们预计该项目将加速高级应用，如 肿瘤跟踪、递送剂量累积和适应性放射治疗。蒙特卡洛平台还将加速开发用于该项目以外的其他医疗应用的新型成像仪。因此，该项目的影响远远超出了直接的临床收益，这本身就是巨大的。