Research Training in Bioenergetics, Oxidative Stress & Metabolic Syndromes

生物能量学、氧化应激研究培训

• 批准号: 7800934
• 负责人: John J Lemasters
• 金额: $ 19.08万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7800934
• 关键词: Bioenergetics; Metabolic syndrome; Oxidative Stress; Research Training

DESCRIPTION (provided by applicant): We propose a training program designed to attract and train pre- and post-doctoral scientists in research on the roles of bioenergetics and oxidative stress in the pathophysiology of metabolic syndrome. The goals of this training program are to nurture talented young individuals in the areas of basic research and clinical investigation, to teach them to design and perform successful research projects, and to give them a solid background in the ethics and methods of scientific research. The objective of this fellowship is to increase the focus of research on metabolic syndrome, bioenergetics, and oxidative stress within MUSC and to train individuals to become independent investigators and academic faculty with an interest in the area of metabolic syndrome and related diseases. Trainees will be selected from a broad group of candidates. Special efforts will be made to identify minority applicants. The training program is designed to provide experience for two and three years, respectively, of full-time effort for postdoctoral and predoctoral fellows working with a group of talented faculty mentors. Research projects are concentrated in the areas of bioenergetics and oxidative stress as they relate to the various aspects of the metabolic syndrome, including insulin resistance, diabetes, obesity, dyslipidemia, hepatic steatosis, inflammation, and consequent tissue injury, especially to the liver and kidney. Weekly conferences with the trainees allow them to present their material to the research community. Additionally, trainees are required to present their research at in-house departmental seminars and submit abstracts to national meetings. Predoctoral students will matriculate through the College of Graduate Studies and follow the course of study for the PhD in Biomedical Sciences. After receiving basic training in cell, molecular, and organismal biology, predoctoral trainees will participate in a graduate course on "Bioenergetics and Oxidative Stress in the Metabolic Syndrome(s)"together with postdoctoral trainees. All trainees will attend required courses in methods in clinical research, responsible conduct of research, and statistics. Trainees will also be offered graduate-level courses on numerous research topics at MUSC to enhance their training experience. PUBLIC HEALTH RELEVANCE: Our program focuses on research training in bioenergetics and oxidative stress related to metabolic syndrome, which is a constellation of clinical conditions, most notably obesity, insulin resistance, Type-2 diabetes, dyslipemia, hypertension, and nonalcoholic fatty liver disease. Affecting about 50 million in the US, metabolic syndrome predisposes atherosclerosis, coronary heart disease, stroke and other diseases, so treatment of metabolic syndrome and its manifestations is key to decreasing morbidity and mortality from these diseases.

描述（由申请人提供）： 我们提出了一项培训计划，旨在吸引和培训博士前和博士后科学家，研究生物能量学和氧化应激在代谢综合征病理生理学中的作用。该培训项目的目标是培养基础研究和临床研究领域的青年才俊，教授他们设计和实施成功的研究项目，并为他们提供扎实的科学研究伦理和方法背景。该奖学金的目的是提高 MUSC 内代谢综合征、生物能量学和氧化应激研究的重点，并培训个人成为对代谢综合征和相关疾病领域感兴趣的独立研究人员和学术人员。学员将从广泛的候选人中选出。我们将做出特别努力来识别少数族裔申请人。该培训计划旨在分别为博士后和博士前研究员提供两年和三年的全职工作经验，与一群才华横溢的教师导师一起工作。研究项目集中在生物能学和氧化应激领域，因为它们与代谢综合征的各个方面有关，包括胰岛素抵抗、糖尿病、肥胖、血脂异常、肝脂肪变性、炎症和随后的组织损伤，尤其是肝脏和肾脏。每周与学员举行的会议使他们能够向研究界展示他们的材料。此外，学员还必须在内部部门研讨会上展示他们的研究成果，并向全国会议提交摘要。博士前学生将通过研究生学院入学，并攻读生物医学科学博士学位。在接受细胞、分子和有机生物学的基础培训后，博士前学员将与博士后学员一起参加“代谢综合征中的生物能量学和氧化应激”研究生课程。所有学员都将参加临床研究方法、负责任的研究行为和统计学方面的必修课程。 MUSC 还将为学员提供有关众多研究主题的研究生水平课程，以增强他们的培训经验。 公共健康相关性：我们的项目侧重于与代谢综合征相关的生物能学和氧化应激的研究培训，代谢综合征是一系列临床病症，最显着的是肥胖、胰岛素抵抗、2 型糖尿病、血脂异常、高血压和非酒精性脂肪肝。代谢综合征影响着美国约 5000 万人，容易引发动脉粥样硬化、冠心病、中风和其他疾病，因此治疗代谢综合征及其表现是降低这些疾病发病率和死亡率的关键。