Pilot and Feasibility Component

项目概要 西北大学乔治·M·奥布莱恩肾脏研究核心中心 (NU- GoKIDNEY）将联合基础和临床研究人员进行重点关注的转化研究 发现肾脏疾病患者的新治疗方法。我们设想服务 由临床前模型核心（核心 A）、治疗开发核心（核心 B）和 临床和转化核心（核心 C）将支持动物模型测试疗法的开发 并将促进潜在候选人进入临床试验。为了实现这一雄心勃勃的愿景， 我们将实施一项试点和可行性计划，该计划将体现 NU-GoKIDNEY 中心的使命和 利用我们的核心实现三个短期目标：1）为高转化率的研究提供资金 潜力； 2）吸引杰出的早期研究人员或以前在肾脏研究之外的研究人员 研究肾脏疾病的领域； 3) 加强机构内和跨机构的合作。通过资助 提议利用 NU-GoKIDNEY 中心的研究人员提出的具有高转化潜力的项目 以确定治疗靶点为核心，我们预计我们的试点和可行性计划将实现五个目标 长期目标：1）获得额外资金； 2）促进早期研究者的职业发展； 3） 扩大以肾脏为重点的研究人员的专业知识； 4）增加协作产品数量；和 5) 促进 NU-GoKIDNEY 中心三个核心之间的协同作用并增加治疗成果 作为 NU-GoKIDNEY 中心的终极使命。因此，我们预计随着时间的推移，我们的飞行员和 可行性计划将促进 NIH 和其他资金的增长，将为劳动力注入新的创意 人才，并将在校园内外培育协同和协作的文化。最终，科学的 NU-GoKIDNEY 中心的环境将刺激创新并为患有肾病的患者带来更好的治疗 肾脏疾病。

PROJECT SUMMARY The mission of the George M. O'Brien Kidney Research Core Center at Northwestern University (NU- GoKIDNEY) is to join basic and clinical investigators to conduct translational research focused on the discovery of novel therapeutic modalities for patients with kidney diseases. We envision that the services provided by the Preclinical Models Core (Core A), the Therapeutics Development Core (Core B) and the Clinical and Translational Core (Core C) will support the development of therapies for testing in animal models and will facilitate the advancement of potential candidates into clinical trials. To achieve this ambitious vision, we will implement a Pilot and Feasibility Program that will embrace the NU-GoKIDNEY Center's Mission and leverage our Cores to deliver three short-term goals: 1) provide funds for research with high translational potential; 2) attract exceptional early-stage investigators or investigators previously outside the kidney research sphere to study kidney diseases; and 3) enhance within- and cross-institutional collaborations. By funding projects with high translational potential from investigators who propose to utilize the NU-GoKIDNEY Center's Cores to identify therapeutic targets, we anticipate that our Pilot and Feasibility Program will accomplish five long-term goals: 1) garner additional funding; 2) promote career development of early-stage investigators; 3) expand the expertise of kidney-focused investigators; 4) increase the number of collaborative products; and 5) promote synergy between the three Cores of the NU-GoKIDNEY Center and increase therapeutic deliverables as the ultimate mission of the NU-GoKIDNEY Center. As such, we anticipate that over time our Pilot and Feasibility Program will promote growth in NIH and other funding, will infuse the workforce with new creative talent and will foster a synergistic and collaborative culture on and across campuses. Ultimately, the scientific environment of the NU-GoKIDNEY Center will spur innovations and lead to better treatments for patients with kidney diseases.