Pilot and Feasibility Component

项目摘要 乔治·M的使命西北大学奥布莱恩肾脏研究核心中心（NU- GoKIDNEY）将加入基础和临床研究人员的行列，开展以 为肾病患者发现新的治疗方式。我们设想， 由临床前模型核心（核心A）、治疗药物开发核心（核心B）和 临床和转化核心（核心C）将支持开发用于动物模型测试的疗法 并将促进潜在候选人进入临床试验。为了实现这一宏伟愿景， 我们将实施一项试点和可行性计划，该计划将包含NU-GoKIDNEY中心的使命， 利用我们的核心，以实现三个短期目标：1）为研究提供资金， 潜力; 2）吸引特殊的早期研究者或以前在肾脏研究之外的研究者 研究肾脏疾病的领域;和3）加强内部和跨机构的合作。通过资助 研究者提出利用NU-GoKIDNEY中心的 核心，以确定治疗目标，我们预计，我们的试点和可行性计划将实现五个 长期目标：1）获得额外资金; 2）促进早期研究人员的职业发展; 3） 扩大以肾脏为重点的研究人员的专业知识; 4）增加合作产品的数量;以及5） 促进NU-GoKIDNEY中心三个核心之间的协同作用，并增加治疗成果 作为NU-GoKIDNEY中心的终极使命。因此，我们预计，随着时间的推移，我们的试点和 可行性计划将促进NIH和其他资金的增长，将为劳动力注入新的创造性 人才，并将促进校园内和跨校园的协同和协作文化。最终，科学 NU-GoKIDNEY中心的环境将刺激创新，并为患者带来更好的治疗。 肾脏疾病

PROJECT SUMMARY The mission of the George M. O'Brien Kidney Research Core Center at Northwestern University (NU- GoKIDNEY) is to join basic and clinical investigators to conduct translational research focused on the discovery of novel therapeutic modalities for patients with kidney diseases. We envision that the services provided by the Preclinical Models Core (Core A), the Therapeutics Development Core (Core B) and the Clinical and Translational Core (Core C) will support the development of therapies for testing in animal models and will facilitate the advancement of potential candidates into clinical trials. To achieve this ambitious vision, we will implement a Pilot and Feasibility Program that will embrace the NU-GoKIDNEY Center's Mission and leverage our Cores to deliver three short-term goals: 1) provide funds for research with high translational potential; 2) attract exceptional early-stage investigators or investigators previously outside the kidney research sphere to study kidney diseases; and 3) enhance within- and cross-institutional collaborations. By funding projects with high translational potential from investigators who propose to utilize the NU-GoKIDNEY Center's Cores to identify therapeutic targets, we anticipate that our Pilot and Feasibility Program will accomplish five long-term goals: 1) garner additional funding; 2) promote career development of early-stage investigators; 3) expand the expertise of kidney-focused investigators; 4) increase the number of collaborative products; and 5) promote synergy between the three Cores of the NU-GoKIDNEY Center and increase therapeutic deliverables as the ultimate mission of the NU-GoKIDNEY Center. As such, we anticipate that over time our Pilot and Feasibility Program will promote growth in NIH and other funding, will infuse the workforce with new creative talent and will foster a synergistic and collaborative culture on and across campuses. Ultimately, the scientific environment of the NU-GoKIDNEY Center will spur innovations and lead to better treatments for patients with kidney diseases.