CORALE-SeroNet Immune Bioanalytics Core

CORALE-SeroNet 免疫生物分析核心

• 批准号: 10222435
• 负责人: Jennifer E Van Eyk
• 金额: $ 85.33万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10222435
• 关键词: 2019-nCoV; Acute-Phase Proteins; Anti-Inflammatory Agents; Antigen-Antibody Complex; Biochemical; Biochemistry; Biological Assay; Biological Process; Biological Response Modifiers; COVID-19 pandemic; Clinical Research; Core Facility; Development; Devices; Disease; Early identification; Eicosanoids; Endothelial Cells; Ensure; Equilibrium; Exhibits; Foundations; Goals; Human; Immune; Immunologic Factors; Immunology procedure; Individual; Infection; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Infrastructure; Investigation; Leukotrienes; Lipoxins; Mass Spectrum Analysis; Measures; Metabolic syndrome; Methods; Obesity; Organization and Administration; Outcome; Pathway interactions; Patients; Peptides; Physiological; Plasma; Play; Population; Population Study; Predisposition; Prostaglandins; Proteins; Reproducibility; Research; Research Personnel; Resolution; Resource Sharing; Resources; Risk; Sampling; Science; Serological; Severities; Severity of illness; System; Therapeutic; Thrombosis; Thromboxanes; Work; absorption; advanced analytics; adverse outcome; combat; complex data; cytokine; data exchange; data integration; data standards; effective therapy; immune function; mortality; mortality risk; novel; novel therapeutic intervention; organ injury; protein metabolite; response; tissue injury

ABSTRACT The Immune Bioanalytics Core (IBC) will serve as a critical Shared Resource Core for our U54 SARS-CoV-2 Serological Sciences Center of Excellence. This centralized resource will provide state-of-the-art infrastructure and expertise in high resolution, directed mass spectrometry for the robust and precise measure of over 500 immune mediators - including immune-modulatory proteins, acute phase proteins, cytokines and eicosanoids – across thousands of human biosamples. This IBC will be responsible for automated sample handling and curation for a number of sample types, protein and metabolite extraction, mass spectrometry and biochemical assay of immune factors, complex data integration, and data transfer, in support of the U54 Projects. As part of the larger SeroNet U54 Centers for Excellence, the IBC will further provide capacity and expertise for measure of immune-modulatory peptides and eicosanoids factors for all SeroNet investigators, as well as provide close assistance with data standardization and cross-Center integration.

摘要 免疫生物分析核心（IBC）将作为我们U 54 SARS-CoV-2的关键共享资源核心 卓越的血清学科学中心。这种集中的资源将提供最先进的基础设施 和专业知识，在高分辨率，定向质谱法的强大和精确的测量超过500 免疫介质-包括免疫调节蛋白、急性期蛋白、细胞因子和类花生酸， 上千个人类生物样本中。该IBC将负责自动化样品处理， 多种样品类型的管理、蛋白质和代谢物提取、质谱分析和生化分析 免疫因子分析、复杂数据集成和数据传输，以支持U 54项目。的一部分 规模更大的SeroNet U 54卓越中心，IBC将进一步提供测量能力和专业知识， 免疫调节肽和类花生酸因子的所有SeroNet研究者，以及提供密切的 协助数据标准化和跨中心集成。