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Center for Environmental and Health Effects of PFAS

PFAS 环境与健康影响中心

基本信息

批准号：
10221364
负责人：
CAROLYN J MATTINGLY
金额：
$ 54.21万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-28 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10221364
关键词：
Acids Age Alligators Animals Archives Back Biological Blood Blood capillaries Blood specimen Body Burden Chemicals Chromatography Clinical Cohort Studies Collection Communities Concentration measurement Cross-Sectional Studies Data Environmental Health Fingerprint Fingers Fluorine Fright Funding Goals Health Human Individual Ions Location Measurement Measures Methods North Carolina Outcome Parents Participant Plants Poly-fluoroalkyl substances Population Reference Standards Research Personnel Research Project Grants Rivers Sampling Science Serum Signal Recognition Particle Source Spottings Superfund Surface System Techniques Technology Thyroid Gland Thyroid Hormones Time Training Universities Venous Water Whole Blood Work analytical method drinking water experimental study exposed human population field study guided inquiry liquid chromatography mass spectrometry method development minimally invasive novel remediation sample collection water treatment

项目摘要

Abstract The NC State Center for Environmental and Health Effects of PFAS focuses on understanding the implications of PFAS exposure in humans and animals in the Cape Fear River Basin of North Carolina. The Cape Fear River in North Carolina is characterized by high levels of a variety of PFAS (per-and poly-fluoroalkyl substances) throughout the watershed. The specific chemicals vary by location with the lower Cape Fear characterized by the presence of novel fluoroethers from chemical manufacturing near Fayetteville, NC, while upstream, the levels of legacy PFAS such as PFOA and PFOS are elevated and frequently exceed the drinking water advisory levels for these chemicals. To better characterize the diversity of PFAS exposures among impacted communities along the Cape Fear River, we have developed this supplement proposal to: 1) further characterize human exposure in communities upriver from Fayetteville, 2) expand analytical capabilities to measure total organic fluorine in biological and environmental samples, and 3) demonstrate feasibility for novel blood collection methods that can be employed in the field for both human and animal blood PFAS analysis.

抽象的北卡罗来纳州 PFAS 环境与健康影响中心致力于了解 PFAS 暴露对开普菲尔河流域人类和动物的影响北卡罗来纳州。北卡罗来纳州的开普菲尔河 (Cape Fear River) 的特点是水位较高。整个流域内存在多种 PFAS（全氟烷基物质和多氟烷基物质）。具体的化学物质因地点而异，开普菲尔下游的特点是存在新的化学物质北卡罗来纳州费耶特维尔附近化学制造过程中产生的氟醚，在上游，传统的 PFAS（例如 PFOA 和 PFOS）含量升高，并且经常超过饮用水标准这些化学品的咨询水平。更好地描述 PFAS 暴露的多样性在开普菲尔河沿岸受影响的社区中，我们开发了此补充品建议：1) 进一步描述费耶特维尔上游社区的人类暴露特征，2) 扩大分析能力以测量生物和环境中的总有机氟样本，3) 证明新型血液采集方法的可行性用于人类和动物血液 PFAS 分析领域。