Center for Environmental and Health Effects of PFAS

摘要 总括 全氟和多氟烷基物质(PFAS)正成为北卡罗来纳州的一个主要公共卫生问题 (北卡罗来纳州)和整个美国。全氟辛烷磺酸由近5,000种已知化合物组成。他们独特的化学物质 利用房地产使消费品和工业产品更多的水分、污渍和油脂 耐受性；它们存在于化妆品和消防泡沫等各种产品中。尽管不断增加 有证据表明它们无处不在地存在于环境中，但对它们的知识匮乏 毒性。对于少数经过充分研究的全氟辛烷磺酸，相关的健康影响包括癌症和对肝脏、甲状腺、 和免疫系统；但人类的暴露水平、作用机制、生物积累或有效 对大多数全氟辛烷磺酸而言，补救办法仍然不清楚。由于最近在 环境和越来越多的人类接触证据我们建议建立一个超级基金研究 全氟辛烷磺酸对环境和人类健康影响项目(SRP)中心。其中的几个 化合物被列入有毒物质和疾病机构的物质优先清单 并被美国环境保护局认为是新出现的令人担忧的污染物。 我们中心的长期目标是增进对PFAS 1)环境和 受影响地区的人体暴露2)甲状腺和免疫的毒性和潜在机制 功能，3)生物积累潜力，4)修复。为了实现我们的目标，我们将聘请一名高度 将整合不同领域(流行病学、环境科学)的领导者的跨学科方法 以及工程、生物学、毒理学、免疫学、数据科学和高级分析) 北卡罗来纳州大学(北卡罗来纳州和东卡罗来纳州大学)；多层次的生物组织 (生物分子、途径、细胞、模式生物(围植生物、蚂蚁、斑马鱼、小鼠)和人类 人口)；最先进的分析技术；尖端数据科学和管理 方法；在跨学科、环境健康科学培训方面的公认记录；以及 与政府和社区利益攸关方建立了良好的伙伴关系。我们的目标是成为值得信赖的 为SRP利益相关者和受影响社区提供资源，并催化发现导致 预防全氟辛烷磺酸暴露，保护人类健康。

ABSTRACT Overall Per- and polyfluoroalkyl substances (PFAS) are emerging as a major public health problem in North Carolina (NC) and across the US. PFAS comprise a class of almost 5,000 known compounds. Their unique chemical properties have been harnessed to make consumer and industrial products more water, stain, and grease resistant; they are found in products as diverse as cosmetics and firefighting foams. Despite increasing evidence that they are found ubiquitously in the environment, there is a paucity of knowledge about their toxicity. For the few well-studied PFAS, associated health effects include cancer and toxicity to the liver, thyroid, and immune system; but human exposure levels, mechanisms of action, bioaccumulation, or effective remediation approaches remain unclear for the majority of PFAS. As a result of recent widespread detection in the environment and increasing evidence of human exposure we propose to establish a Superfund Research Program (SRP) Center for Environmental and Human Health Effects of PFAS. Several of these compounds are included on the Substance Priority List of the Agency for Toxic Substances and Disease Registry and are considered contaminants of emerging concern by the US Environmental Protection Agency. The long-term objective of our Center is to advance understanding about PFAS 1) environmental and human exposure in impacted areas, 2) toxicity and underlying mechanisms of thyroid and immune function, 3) bioaccumulation potential, and 4) remediation. To meet our objective we will employ a highly transdisciplinary approach that will integrate leaders in diverse fields (epidemiology, environmental science and engineering, biology, toxicology, immunology, data science, and advanced analytics) across two major NC Universities (NC State and East Carolina Universities); multiple levels of biological organization (biomolecule, pathway, cell, model organisms (periphyton, mayflies, zebrafish, mouse), and human populations); state-of-the-art analytical technologies; cutting-edge data science and management approaches; a recognized track record in interdisciplinary, environmental health science training; and well-established partnerships with government and community stakeholders. We aim to be a trusted resource for SRP stakeholders and impacted communities and to catalyze discovery of information that leads to prevention of PFAS exposure and protection of human health.