Center for Environmental and Health Effects of PFAS

摘要 整体 全氟和多氟烷基物质（PFAS）正在成为北卡罗来纳州的一个主要公共卫生问题 (NC)和美国各地。PFAS包含近5,000种已知化合物。它们独特的化学物质 利用这些特性使消费品和工业产品中的水、污渍和油脂更多 耐腐蚀;它们存在于化妆品和消防泡沫等各种产品中。尽管越来越多 有证据表明，它们在环境中无处不在，关于它们的知识很少。 毒性对于少数研究充分的PFAS，相关的健康影响包括癌症和对肝脏，甲状腺， 但人类接触水平、作用机制、生物累积性或有效性， 对于大多数PFAS，补救方法仍不清楚。由于最近广泛发现， 环境和越来越多的人类接触的证据，我们建议建立一个超级基金研究 计划（SRP）中心PFAS的环境和人类健康影响。几个这样 这些化合物被列入有毒物质和疾病管理局的物质优先清单 登记册和被认为是新出现的污染物的关注，由美国环境保护署。 我们中心的长期目标是促进对PFAS 1）环境和 受影响地区的人类接触，2）甲状腺和免疫系统的毒性和基本机制 功能，3）生物累积潜力和4）补救。为了实现我们的目标，我们将聘请一个高度 跨学科的方法，将整合不同领域的领导者（流行病学，环境科学 和工程，生物学，毒理学，免疫学，数据科学和高级分析）在两个主要的 北卡罗来纳大学（北卡罗来纳州立大学和东卡罗莱纳大学）;生物组织的多个层次 （生物分子、途径、细胞、模式生物（附着生物、蜉蝣、斑马鱼、小鼠）和人类） 人口）;最先进的分析技术;尖端的数据科学和管理 在跨学科环境卫生科学培训方面有公认的记录;以及 与政府和社区利益攸关方建立了良好的伙伴关系。我们的目标是成为一个值得信赖的 为SRP利益相关者和受影响的社区提供资源，并促进发现信息， 预防PFAS暴露和保护人类健康。

ABSTRACT Overall Per- and polyfluoroalkyl substances (PFAS) are emerging as a major public health problem in North Carolina (NC) and across the US. PFAS comprise a class of almost 5,000 known compounds. Their unique chemical properties have been harnessed to make consumer and industrial products more water, stain, and grease resistant; they are found in products as diverse as cosmetics and firefighting foams. Despite increasing evidence that they are found ubiquitously in the environment, there is a paucity of knowledge about their toxicity. For the few well-studied PFAS, associated health effects include cancer and toxicity to the liver, thyroid, and immune system; but human exposure levels, mechanisms of action, bioaccumulation, or effective remediation approaches remain unclear for the majority of PFAS. As a result of recent widespread detection in the environment and increasing evidence of human exposure we propose to establish a Superfund Research Program (SRP) Center for Environmental and Human Health Effects of PFAS. Several of these compounds are included on the Substance Priority List of the Agency for Toxic Substances and Disease Registry and are considered contaminants of emerging concern by the US Environmental Protection Agency. The long-term objective of our Center is to advance understanding about PFAS 1) environmental and human exposure in impacted areas, 2) toxicity and underlying mechanisms of thyroid and immune function, 3) bioaccumulation potential, and 4) remediation. To meet our objective we will employ a highly transdisciplinary approach that will integrate leaders in diverse fields (epidemiology, environmental science and engineering, biology, toxicology, immunology, data science, and advanced analytics) across two major NC Universities (NC State and East Carolina Universities); multiple levels of biological organization (biomolecule, pathway, cell, model organisms (periphyton, mayflies, zebrafish, mouse), and human populations); state-of-the-art analytical technologies; cutting-edge data science and management approaches; a recognized track record in interdisciplinary, environmental health science training; and well-established partnerships with government and community stakeholders. We aim to be a trusted resource for SRP stakeholders and impacted communities and to catalyze discovery of information that leads to prevention of PFAS exposure and protection of human health.