Neuroimaging Core
Neuroimaging Core
批准号:
10216924
负责人:
PAUL M THOMPSON
金额:
$51.36万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-07-01 至 2023-06-30
关键词:
AgingAir PollutantsAir PollutionAlzheimer&aposs DiseaseAlzheimer&aposs disease brainAlzheimer&aposs disease riskAmericanAmygdaloid structureAmyloidAngiographyAnimalsAnisotropyAutopsyBlood - brain barrier anatomyBlood VesselsBrainBrain imagingBrain regionCerebrovascular CirculationClinicalCognitionCognitiveCognitive agingComputer softwareConfocal MicroscopyDataData AnalysesDiffuseDiffusion Magnetic Resonance ImagingDiseaseEpisodic memoryEquationExperimental Animal ModelExposure toHeterogeneityHippocampus (Brain)HumanImageImage AnalysisImmunofluorescence MicroscopyImpaired cognitionInjuryLeadMRI ScansMachine LearningMagnetic Resonance ImagingMapsMeasuresMedialMediatingMediationMissionModelingMusNerve DegenerationParticipantPatternPopulationPopulation StudyRadialResearchResearch PersonnelRiskScanningScientistSpin LabelsStandardizationStructureTemporal LobeTestingThickTimeValidationWhite Matter HyperintensityWorkbasebiomarker signatureblood-brain barrier permeabilizationcerebrovascularcohortcontrast enhanceddata standardsdimensional analysisexecutive functionfollow-upfrontal lobehigh dimensionalityin vivomagnetic resonance imaging biomarkermild cognitive impairmentneuroimagingneurovascular unitnovelpre-clinicalprospectiveresponsetau Proteinstooltractographytraitwhite matter
中文摘要
抽象核心B
成像核心 B(Paul Thompson,总监)为项目 1-4 提供大脑图像分析,其中分析
对空气污染的神经退行性反应。子核心 B1(M. Braskie)支持关于人类的项目 1 和 2
大脑 MR 图像。子核心 B2 (B. Zlokovic) 支持关于小鼠大脑的项目 3 和 4。
子核心 B1 人类神经影像学
目标 1:在 ADNI、WHIMS 和 VETSA 队列中执行标准化结构图像分析以评估
体素皮质厚度、选定的阿尔茨海默病 (AD) 相关皮质下结构的体积
(海马体和杏仁核),以及使用 FreeSurfer 软件的区域白质。我们还将评估白色
物质高信号量。在 ADNI 和 VETSA 中,我们将分析扩散张量成像扫描。
目标 2:使用机器学习生成结构 MRI 皮质特征和相关的预测风险
与临床前 AD、轻度认知障碍和 AD 风险相关的评分。
目标 3:支持项目 1 和 2 在其提出的调解分析中使用结构性目标方法
方程模型 (SEM) 和具有高维分析的不可知论方法。
子核心 B2,小鼠脑成像。
目标 1. 进行体内小鼠脑成像以评估脑血流量、血脑屏障 (BBB)
渗透性、血管造影和 MRI 纤维束成像。
目标 2. 通过免疫荧光共聚焦显微镜对神经血管单元和血脑屏障进行死后研究。
目标 3. 超高场 MRI 通过扩散率和纤维束成像图检测小鼠连接性变化
通过动态对比增强 (DCE)-MRI 量化 BBB 通透性。
目标 4 分析项目 3 和 4 中的小鼠数据。
英文摘要
Abstract Core B
The Imaging Core B (Paul Thompson, Director) provides brain image analysis for Projects 1-4, which analyze
neurodegenerative responses to air pollution. Sub-core B1 (M. Braskie) supports Projects 1 and 2 on human
brain MR images. Sub-core B2 (B. Zlokovic) supports Projects 3 and 4 on mouse brain.
Sub-core B1 Human Neuroimaging
Aim 1: Perform standardized structural image analyses in the ADNI, WHIMS and VETSA cohorts to assess
voxelwise cortical thickness, volumes of selected Alzheimer's disease (AD)-relevant subcortical structures
(hippocampus and amygdala), and regional white matter using FreeSurfer software. We will also assess white
matter hyperintensity volumes. In ADNI and VETSA we will analyze diffusion tensor imaging scans.
Aim 2: Use machine learning to generate structural MRI cortical signatures and associated predicted risk
scores related to risk for preclinical AD, mild cognitive impairment, and AD.
Aim 3: Support Projects 1 & 2 in their proposed mediation analyses using both targeted approach in structural
equation models (SEM) and agnostic approach with high-dimensional analyses.
Sub-Core B2, Mouse brain imaging.
Aim 1. Perform in vivo mouse brain imaging to assess cerebral blood flow, blood brain barrier (BBB)
permeability, vascular angiography, and MRI tractography.
Aim 2. Postmortem studies of the neurovascular unit & BBB by confocal microscopy for immunofluorescence.
Aim 3. Ultra-highfield MRI to detect mouse connectivity changes through diffusivity and tractography maps &
quantification of BBB permeability by dynamic contrast enhanced (DCE)-MRI.
Aim 4 Analyze mouse data from Projects 3 and 4.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CARE4Kids: Imaging Biomarker Core
-
批准号:10203601
-
项目类别:
-
资助金额:$23.01万
-
财政年份:2021
-
负责人:PAUL M THOMPSON
-
依托单位:
ENIGMA World Aging Center
-
批准号:10576402
-
项目类别:
-
资助金额:$64.94万
-
财政年份:2021
-
负责人:PAUL M THOMPSON
-
依托单位:
ENIGMA World Aging Center
-
批准号:10328963
-
项目类别:
-
资助金额:$64.96万
-
财政年份:2021
-
负责人:PAUL M THOMPSON
-
依托单位:
FiberNET: Deep learning to evaluate brain tract integrity worldwide and in AD
-
批准号:10814696
-
项目类别:
-
资助金额:$7.5万
-
财政年份:2020
-
负责人:PAUL M THOMPSON
-
依托单位:
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMA
-
批准号:9892045
-
项目类别:
-
资助金额:$59.51万
-
财政年份:2018
-
负责人:PAUL M THOMPSON
-
依托单位:
Neuroimaging Core
-
批准号:10456750
-
项目类别:
-
资助金额:$50.97万
-
财政年份:2018
-
负责人:PAUL M THOMPSON
-
依托单位:
Multi-Source Sparse Learning to Identify MCI and Predict Decline
-
批准号:9008380
-
项目类别:
-
资助金额:$281.54万
-
财政年份:2016
-
负责人:PAUL M THOMPSON
-
依托单位:
Data Science Research
-
批准号:9108711
-
项目类别:
-
资助金额:$179.22万
-
财政年份:2016
-
负责人:PAUL M THOMPSON
-
依托单位:
ENIGMA Center for Worldwide Medicine, Imaging & Genomics
-
批准号:9108710
-
项目类别:
-
资助金额:$236.95万
-
财政年份:2014
-
负责人:PAUL M THOMPSON
-
依托单位:
Growth factors, neuroinflammation, exercise, and brain integrity
-
批准号:8696676
-
项目类别:
-
资助金额:$293.9万
-
财政年份:2014
-
负责人:PAUL M THOMPSON
-
依托单位:
ENIGMA Center for Worldwide Medicine, Imaging & Genomics
-
批准号:8935792
-
项目类别:
-
资助金额:$236.69万
-
财政年份:2014
-
负责人:PAUL M THOMPSON
-
依托单位:
ENIGMA Center for Worldwide Medicine, Imaging & Genomics
-
批准号:8774373
-
项目类别:
-
资助金额:$208.76万
-
财政年份:2014
-
负责人:PAUL M THOMPSON
-
依托单位:
Alzheimer's disease risk analyzed using population imaging genomics
-
批准号:8736034
-
项目类别:
-
资助金额:$50.24万
-
财政年份:2011
-
负责人:PAUL M THOMPSON
-
依托单位:
Alzheimer's disease risk analyzed using population imaging genomics
-
批准号:8321443
-
项目类别:
-
资助金额:$24.25万
-
财政年份:2011
-
负责人:PAUL M THOMPSON
-
依托单位:
Alzheimer's disease risk analyzed using population imaging genomics
-
批准号:8827957
-
项目类别:
-
资助金额:$25.99万
-
财政年份:2011
-
负责人:PAUL M THOMPSON
-
依托单位:
Alzheimer's disease risk analyzed using population imaging genomics
-
批准号:8153468
-
项目类别:
-
资助金额:$50.24万
-
财政年份:2011
-
负责人:PAUL M THOMPSON
-
依托单位:
Alzheimer's disease risk analyzed using population imaging genomics
-
批准号:8900153
-
项目类别:
-
资助金额:$48.73万
-
财政年份:2011
-
负责人:PAUL M THOMPSON
-
依托单位:
HARDI MAPPING OF DISEASE EFFECTS ON THE BRAIN
-
批准号:8362853
-
项目类别:
-
资助金额:$3.03万
-
财政年份:2011
-
负责人:PAUL M THOMPSON
-
依托单位:
PEPTIDE-BASED BORONO LECTINS: NEW TOOLS FOR COLON CANCER
-
批准号:8167870
-
项目类别:
-
资助金额:$16.35万
-
财政年份:2010
-
负责人:PAUL M THOMPSON
-
依托单位:
HARDI MAPPING OF DISEASE EFFECTS ON THE BRAIN
-
批准号:8170458
-
项目类别:
-
资助金额:$2.57万
-
财政年份:2010
-
负责人:PAUL M THOMPSON
-
依托单位:
海外基金