Neuroimaging Core

神经影像核心

• 批准号: 10216924
• 负责人: PAUL M THOMPSON
• 金额: $ 51.36万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216924
• 关键词: Aging; Air Pollutants; Air Pollution; Alzheimer' s Disease; Alzheimer' s disease brain; Alzheimer' s disease risk; American; Amygdaloid structure; Amyloid; Angiography; Animals; Anisotropy; Autopsy; Blood - brain barrier anatomy; Blood Vessels; Brain; Brain imaging; Brain region; Cerebrovascular Circulation; Clinical; Cognition; Cognitive; Cognitive aging; Computer software; Confocal Microscopy; Data; Data Analyses; Diffuse; Diffusion Magnetic Resonance Imaging; Disease; Episodic memory; Equation; Experimental Animal Model; Exposure to; Heterogeneity; Hippocampus (Brain); Human; Image; Image Analysis; Immunofluorescence Microscopy; Impaired cognition; Injury; Lead; MRI Scans; Machine Learning; Magnetic Resonance Imaging; Maps; Measures; Medial; Mediating; Mediation; Mission; Modeling; Mus; Nerve Degeneration; Participant; Pattern; Population; Population Study; Radial; Research; Research Personnel; Risk; Scanning; Scientist; Spin Labels; Standardization; Structure; Temporal Lobe; Testing; Thick; Time; Validation; White Matter Hyperintensity; Work; base; biomarker signature; blood-brain barrier permeabilization; cerebrovascular; cohort; contrast enhanced; data standards; dimensional analysis; executive function; follow-up; frontal lobe; high dimensionality; in vivo; magnetic resonance imaging biomarker; mild cognitive impairment; neuroimaging; neurovascular unit; novel; pre-clinical; prospective; response; tau Proteins; tool; tractography; trait; white matter

Abstract Core B The Imaging Core B (Paul Thompson, Director) provides brain image analysis for Projects 1-4, which analyze neurodegenerative responses to air pollution. Sub-core B1 (M. Braskie) supports Projects 1 and 2 on human brain MR images. Sub-core B2 (B. Zlokovic) supports Projects 3 and 4 on mouse brain. Sub-core B1 Human Neuroimaging Aim 1: Perform standardized structural image analyses in the ADNI, WHIMS and VETSA cohorts to assess voxelwise cortical thickness, volumes of selected Alzheimer's disease (AD)-relevant subcortical structures (hippocampus and amygdala), and regional white matter using FreeSurfer software. We will also assess white matter hyperintensity volumes. In ADNI and VETSA we will analyze diffusion tensor imaging scans. Aim 2: Use machine learning to generate structural MRI cortical signatures and associated predicted risk scores related to risk for preclinical AD, mild cognitive impairment, and AD. Aim 3: Support Projects 1 & 2 in their proposed mediation analyses using both targeted approach in structural equation models (SEM) and agnostic approach with high-dimensional analyses. Sub-Core B2, Mouse brain imaging. Aim 1. Perform in vivo mouse brain imaging to assess cerebral blood flow, blood brain barrier (BBB) permeability, vascular angiography, and MRI tractography. Aim 2. Postmortem studies of the neurovascular unit & BBB by confocal microscopy for immunofluorescence. Aim 3. Ultra-highfield MRI to detect mouse connectivity changes through diffusivity and tractography maps & quantification of BBB permeability by dynamic contrast enhanced (DCE)-MRI. Aim 4 Analyze mouse data from Projects 3 and 4.

抽象核心B 成像核心B（Paul Thompson，主任）为项目1-4提供大脑图像分析， 空气污染的神经退行性反应次核心B1（M. Braskie）支持项目1和2对人类 脑MR图像。子核心B2（B. Zlokovic）支持小鼠大脑的项目3和4。 亚核心B1人类神经成像 目的1：在ADNI、WHIMS和VETSA队列中进行标准化结构图像分析，以评估 体素皮质厚度，选定的阿尔茨海默病（AD）相关皮质下结构的体积 （海马和杏仁核）和区域白色物质。我们还将评估白色 高密度物质体积。在ADNI和VETSA中，我们将分析弥散张量成像扫描。 目标2：使用机器学习生成结构MRI皮质特征和相关预测风险 与临床前AD、轻度认知障碍和AD风险相关的评分。 目标3：支持项目1和项目2在其拟议的调解分析中使用结构性的有针对性的方法 方程模型（SEM）和高维分析的不可知方法。 子核心B2，小鼠脑成像。 目标1.进行体内小鼠脑成像以评估脑血流、血脑屏障（BBB） 渗透性、血管造影和MRI纤维束成像。 目标二。通过免疫荧光共聚焦显微镜对神经血管单位和血脑屏障进行死后研究。 目标3。超高场MRI通过扩散率和追踪成像图检测小鼠连接性变化 通过动态对比增强（DCE）-MRI定量BBB渗透性。 目的4分析项目3和项目4的小鼠数据。